Article
Pharmacology & Pharmacy
Siqi Xia, Chaoran Xu, Fuyi Liu, Gao Chen
Summary: MicroRNA (miRNA)-mediated gene silencing is a promising method of RNA interference for treating central nervous system diseases. Although several miRNA-based therapeutics have entered clinical trials for various diseases, clinical trials specifically targeting central nervous system diseases are scarce, and effective treatments for these diseases are lacking. This review provides an overview of miRNA-based therapeutics for central nervous system diseases, including their principles, progress, and potential obstacles in drug development, as well as possible solutions for the future.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wenbiao Zhang, Yongjiang Li, Guanjun Chen, Xiaochun Yang, Junfeng Hu, Xiaofei Zhang, Guokai Feng, Hua Wang
Summary: In this study, three integrin alpha 6-targeted molecular imaging agents were used to accurately detect central nervous system leukemia (CNS-L) in mice, showing promising results with strong imaging signals compared to clinically available imaging models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Stuart Madden, Enrique Carrazana, Adrian L. Rabinowicz
Summary: Intranasal delivery of drugs provides advantages in ease of use, rapid onset, and patient experience, making it particularly relevant for patients with acute events related to central nervous system (CNS) conditions. Adaptation of intranasal formulations to the nasal cavity's anatomical and physiological characteristics, including limited dose volume, restricted surface area, and mucosal absorption barriers, is crucial. The addition of alkylsaccharide permeation enhancers, such as dodecyl maltoside (DDM), can optimize drug absorption within the constraints of nasal delivery, as demonstrated by FDA-approved intranasal medications for epilepsy, acute opioid overdose, and migraine.
Article
Chemistry, Multidisciplinary
Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng, Mingyuan Gao
Summary: The delivery and elimination pathways of intranasally administered nanodrugs were investigated using a PEGylated Fe3O4 nanoparticle labeled with a fluorescent dye. The distribution and elimination of the nanoparticles in the brain were studied through magnetic resonance imaging and fluorescence imaging, providing important insights for therapeutic applications of CNS drugs.
Article
Nanoscience & Nanotechnology
Xu Liu, Tian Xia, Yiran Fang, Huaqin Zuo, Xiaoqing Dong, Peipei Xu, Jian Ouyang
Summary: This study developed a novel drug delivery system using exosomes as carriers to deliver drugs to tumor cells. By conjugating anti-CD22 antibody fragments and encapsulating doxorubicin, the system effectively crossed the blood-brain barrier and exhibited significant therapeutic effects on lymphoma cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
John P. Seibyl
Summary: Diseases of the central nervous system, such as Alzheimer's and Parkinson's, are common and chronic conditions with significant morbidity. Abnormal protein accumulation and spread in the brain are found to be the primary factors in neurotoxicity and disruption of functional networks. Clinical trials are currently investigating various therapies to target these proteinopathies, although they face challenges in accurate diagnosis, variable rates of progression, and efficacy measures.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Neurosciences
Qian Li, Zhaobin Ma, Shuhua Qin, Wei-Jiang Zhao
Summary: The incidence of nervous system diseases is increasing, calling for safe and effective treatments. With traditional drug research becoming slower and costlier, virtual screening (VS) with the help of computer-aided drug design (CADD) is becoming a popular and efficient method for new drug development. Recent advancements have made it possible to transform non-neuronal cells into functional neurons using small molecular compounds, expanding the potential applications of VS technology.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Tianyou Liu, Qinglian Xie, Zaiquan Dong, Qiang Peng
Summary: The treatment of central nervous system disorders is challenging due to the presence of the blood-brain barrier (BBB). Nanoparticles-based drug delivery systems have shown great potential in overcoming the BBB and treating CNS diseases. This article summarizes the recent progress in nanoparticles-based systems for CNS delivery and discusses the prerequisites, drawbacks, and challenges of nanocarriers in this field, such as protein corona formation.
Review
Chemistry, Medicinal
Lorena R. Lizarraga-Valderrama
Summary: Essential oils have a wide range of biological activities and can produce anxiolytic, antidepressant, sedative, and anticonvulsant effects on the nervous system. Animal models have shown involvement of multiple neurotransmitter systems leading to measurable physiological effects in the brain, and clinical trials have demonstrated their influence on physiological parameters and psychological effects. More research is needed to validate their influence on the human central nervous system and their potential as drugs for mental illnesses.
PHYTOTHERAPY RESEARCH
(2021)
Review
Immunology
Janaki Manoja Vinnakota, Robert Zeiser
Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective therapy for hematological malignancies, but acute Graft versus host disease (GVHD) as a side effect may cause immune-mediated damage to the central nervous system (CNS). Recent preclinical data suggest that microglia and T cells play crucial roles in this process, but accurate diagnosis of CNS damage etiology in clinical settings remains a challenge.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Weipeng Shi, Jing Zhang, Zhen Shang, Yingze Zhang, Yanzhi Xia, Haitao Fu, Tengbo Yu
Summary: Microglia play a crucial role in the central nervous system by influencing its development, homeostasis, and disease treatments. They have been linked to various neurodegenerative diseases in both humans and animal models, and exhibit different inflammatory responses following brain or spinal cord injury. Depletion of microglia can have both positive and negative effects in the treatment of CNS diseases, and their subsequent repopulation not only treats diseases but also reveals disease mechanisms. Although this field is still in its early stages, microglial repopulation therapy has shown promising results and holds potential therapeutic prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Swati Shah, Mitchell L. Turner, Xueyi Chen, Beau M. Ances, Dima A. Hammoud, Elizabeth W. Tucker
Summary: Diagnosis, monitoring, and assessing response to therapy of CNS infections is challenging. Molecular imaging techniques can complement anatomic imaging for studying the development and treatment response of CNS infections. Pathogen-specific radiotracers can accurately diagnose CNS infections and have the potential to cross the blood-brain barrier.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Craig T. Jacobs, Peng Huang
Summary: The development of the vertebrate central nervous system is tightly regulated by highly conserved cell signalling pathways, with Notch and Hedgehog pathways playing key roles. These pathways interact in a complex manner throughout CNS development, with Notch signaling often regulating Hedgehog response and vice versa. The intricate crosstalk between Notch and Hedgehog pathways highlights the interconnectivity and context-dependent modes of interaction between them, within a wider, multi-pathway signalling network.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Materials Science, Multidisciplinary
Qing Li, Xinxin Shao, Xianglin Dai, Qiong Guo, Bolei Yuan, Ying Liu, Wei Jiang
Summary: This article discusses the application of hydrogels in the treatment of CNS disorders. Developing a carrier that promotes the delivery of therapeutic agents into the brain is crucial due to the complex pathological mechanisms and unique biological microenvironment of the CNS.
NPG ASIA MATERIALS
(2022)
Letter
Clinical Neurology
M. MacGregor Sharp, D. Bulters, S. Brandner, J. Holton, A. Verma, D. J. Werring, R. O. Carare
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2019)
Article
Clinical Neurology
Yeona Kang, Claire Henchcliffe, Ajay Verma, Shankar Vallabhajosula, Bin He, Paresh J. Kothari, Kane O. Pryor, P. David Mozley
JOURNAL OF NEUROIMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carolynn Gaut, Jenna M. Sullivan, Barbara Biscaro, Edward J. Soares, Katharine Nicholson, Jack Hoppin, Ajay Verma
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Neurosciences
Shani Waninger, Chris Berka, Marija Stevanovic Karic, Stephanie Korszen, P. David Mozley, Claire Henchcliffe, Yeona Kang, Jacob Hesterman, Tomer Mangoubi, Ajay Verma
JOURNAL OF PARKINSONS DISEASE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan P. Dyke, Helen S. Xu, Ajay Verma, Henning U. Voss, J. Levi Chazen
Article
Neurosciences
Marta Castellano, David Ibanez-Soria, Eleni Kroupi, Javier Acedo, Michela Campolo, Aureli Soria-Frisch, Josep Valls-Sole, Ajay Verma, Giulio Ruffini
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Medicine, Research & Experimental
Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze, Ajay Verma
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Clinical Neurology
Jacqui T. Nimmo, Harry Smith, Chang Yi Wang, Jessica L. Teeling, James A. R. Nicoll, Ajay Verma, Jean-Cosme Dodart, Zhi Liu, Feng Lin, Roxana O. Carare
Summary: Immunotherapy with the UB-312 vaccine was effective in preventing functional deficits and central and peripheral pathology in Thy1SNCA/15 mice, showing reduced levels of alpha Syn oligomers in the brain regions and a significant reduction in alpha Syn load in the colon.
ACTA NEUROPATHOLOGICA
(2022)
Article
Medicine, Research & Experimental
Kawita M. S. Kanhai, Sebastiaan C. Goulooze, Jeroen van Der Grond, Amy C. Harms, Thomas Hankemeier, Ajay Verma, Gersham Dent, Juan Chavez, Henri Meijering, Geert Jan Groeneveld
Summary: The study quantified the kinetics of myelin breakdown products in patients with MS using deuterium labeling and mass spectrometry. The turnover rate of myelin breakdown products in the cerebrospinal fluid was found to be different in patients with MS compared to healthy subjects, suggesting potential differences in myelin production and degradation processes between the two groups.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Analytical
Bikash Baishya, Ajay Verma, Rashmi Parihar
Summary: CDCl3 is a commonly used solvent for NMR investigations of organic compounds, but the longer acquisition time for C-13 NMR can be a challenge. By utilizing a biphasic system with two immiscible solvents, the speed of C-13 observation and signal to noise ratio can be significantly improved, leading to a more than twofold reduction in experimental time and sensitivity boost for H-1 NMR and other NMR experiments.
Article
Clinical Neurology
Ajay Verma, Jacob Y. Hesterman, J. Levi Chazen, Robert Holt, Patrick Connolly, Laura Horky, Shankar Vallabhajosula, P. David Mozley
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2020)
Article
Medicine, Research & Experimental
Curt Mazur, Berit Powers, Kenneth Zasadny, Jenna M. Sullivan, Hemi Dimant, Fredrik Kamme, Jacob Hesterman, John Matson, Michael Oestergaard, Marc Seaman, Robert W. Holt, Mohammed Qutaish, Ildiko Polyak, Richard Coelho, Vijay Gottumukkala, Carolynn M. Gaut, Marc Berridge, Nazira J. Albargothy, Louise Kelly, Roxana O. Carare, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze, Ajay Verma
Meeting Abstract
Clinical Neurology
A. Ghayoor, X. Wang, K. Kanhai, O. R. Thon, J. Hesterman, A. Verma, G. J. Groeneveld, K. C. Evans
MULTIPLE SCLEROSIS JOURNAL
(2019)
Article
Engineering, Biomedical
Amir H. Meghdadi, Djordje Popovic, Gregory Rupp, Stephanie Smith, Chris Berka, Ajay Verma
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2019)
Meeting Abstract
Clinical Neurology
A. M. Willetts, J. Booker, M. Gatherer, N. J. Albargothy, A. Verma, R. O. Weller, R. O. Carare, C. A. Hawkes
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2019)