C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway

Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice

(2015) Iolanda Lazaro et al.   DIABETES

Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance

(2015) Yu B.Y. Sun et al.   KIDNEY INTERNATIONAL

Chaihuang-Yishen Granule Inhibits Diabetic Kidney Disease in Rats through Blocking TGF-β/Smad3 Signaling

(2014) Ting Ting Zhao et al.   PLoS One

C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration

(2013) Ying Tang et al.   CLINICAL SCIENCE

Positive association between high-sensitivity C-reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6-year follow-up

(2013) Chaochen Wang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

(2013) Shun-Min Yang et al.   DIABETOLOGIA

Transforming Growth Factor β Integrates Smad 3 to Mechanistic Target of Rapamycin Complexes to Arrest Deptor Abundance for Glomerular Mesangial Cell Hypertrophy

(2013) Falguni Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis

(2013) L. Jiang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory Markers and Risk of Type 2 Diabetes: A systematic review and meta-analysis

(2012) X. Wang et al.   DIABETES CARE

Serum amyloid A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients

(2012) Anne Julie Overgaard et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

C-Reactive Protein Induces Interleukin-6 and Thrombospondin-1 Protein and mRNA Expression through Activation of Nuclear Factor-ĸB in HK-2 Cells

(2012) Hai-rong Wang et al.   KIDNEY & BLOOD PRESSURE RESEARCH

C-reactive Protein Is Directly Associated with Urinary Albumin-to-Creatinine Ratio

(2011) Graciela Zambrano-Galvan et al.   ARCHIVES OF MEDICAL RESEARCH

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

(2011) C. K. Tan et al.   DIABETES

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes

(2011) F. Liu et al.   DIABETOLOGIA

Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

(2011) S. M. Ka et al.   DIABETOLOGIA

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice

(2011) Zi Li et al.   LABORATORY INVESTIGATION

The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential

(2010) H. Y. Chen et al.   DIABETES

C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II–Induced Hypertensive Cardiac Disease

(2010) Rongxin Zhang et al.   HYPERTENSION

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mouse Models of Diabetic Nephropathy

(2009) F. C. Brosius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

(2008) Vijay Koka et al.   AMERICAN JOURNAL OF PATHOLOGY

Latent TGF- 1 Protects Against Crescentic Glomerulonephritis

(2008) X. R. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

(2008) A. C. K. Chung et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Raptor-rictor axis in TGFβ-induced protein synthesis

(2007) Falguni Das et al.   CELLULAR SIGNALLING