Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

(2015) Kyung-Jong Lee et al.   NUCLEIC ACIDS RESEARCH

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines

(2015) Julien Bouley et al.   Oncotarget

SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein Stability

(2014) R. Watanabe et al.   CANCER RESEARCH

Induction of p21CIP1 Protein and Cell Cycle Arrest after Inhibition of Aurora B Kinase Is Attributed to Aneuploidy and Reactive Oxygen Species

(2014) Geeta Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for p38 in transcriptional elongation of p21CIP1in response to Aurora B inhibition

(2013) Geeta Kumari et al.   CELL CYCLE

Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

(2013) Marianna Trakala et al.   CELL CYCLE

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

(2012) Yan Liu et al.   EMBO Molecular Medicine

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Aurora B kinase phosphorylates and instigates degradation of p53

(2012) C. P. Gully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Protein phosphatase 1 regulators in DNA damage signaling

(2011) Thomas Küntziger et al.   CELL CYCLE

PP1/Repo-Man Dephosphorylates Mitotic Histone H3 at T3 and Regulates Chromosomal Aurora B Targeting

(2011) Junbin Qian et al.   CURRENT BIOLOGY

Ku Regulates Signaling to DNA Damage Response Pathways through the Ku70 von Willebrand A Domain

(2011) V. L. Fell et al.   MOLECULAR AND CELLULAR BIOLOGY

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

Repo-Man Controls a Protein Phosphatase 1-Dependent Threshold for DNA Damage Checkpoint Activation

(2010) Aimin Peng et al.   CURRENT BIOLOGY

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation

(2009) Jia Liu et al.   BRAIN RESEARCH

Distinct Roles of BARD1 Isoforms in Mitosis: Full-Length BARD1 Mediates Aurora B Degradation, Cancer-Associated BARD1  Scaffolds Aurora B and BRCA2

(2009) S. Ryser et al.   CANCER RESEARCH

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

(2009) A. Oke et al.   CANCER RESEARCH

Identification of XAF1 as a novel cell cycle regulator through modulating G2/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer

(2009) J. Wang et al.   CARCINOGENESIS

Aurora kinase inhibitors

(2009) J.J.E.M. Kitzen et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

Short and long-term tumor cell responses to Aurora kinase inhibitors

(2009) Megan R. Dreier et al.   EXPERIMENTAL CELL RESEARCH

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

(2009) Hao G. Nguyen et al.   FASEB JOURNAL

The Aurora kinase family in cell division and cancer

(2008) Gerben Vader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

(2008) E. Walsby et al.   HAEMATOLOGICA

Identification of CDK2 substrates in human cell lysates

(2008) Yong Chi et al.   GENOME BIOLOGY

Aurora kinases as targets for cancer therapy

(2007) Giannis Mountzios et al.   CANCER TREATMENT REVIEWS