Article
Cell Biology
Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Hua Huang, Ruining Pan, Yue Zhao, Huan Li, Huiyu Zhu, Sijia Wang, Aamir Ali Khan, Juan Wang, Xinhui Liu
Summary: This study reveals the crucial roles of L3MBTL2 and CGA in tumor development. L3MBTL2 represses CGA through an H2AK119ub1-dependent mechanism, and the individual tumor suppressor role of CGA in PDAC is partly dependent on its own glycosylation.
Article
Medicine, General & Internal
Tao Hu, Yunfeng Niu, Jianfeng Fu, Zhiming Dong, Dongwei He, Junfeng Liu
Summary: The study found that PCNA-AS1 is highly expressed in esophageal squamous cell carcinoma and is associated with patient prognosis. It can promote tumor cell proliferation, invasion, and migration, and upregulate PCNA expression through a competitive endogenous RNA mechanism.
Article
Multidisciplinary Sciences
Toufic Kassouf, Rohit Shrivastava, Igor Meszka, Aymeric Bailly, Jolanta Polanowska, Helene Trauchessec, Jessica Mandrioli, Serena Carra, Dimitris P. Xirodimas
Summary: The elimination of aberrant inclusions is a potential therapeutic approach for neurodegeneration. In amyotrophic lateral sclerosis (ALS), inhibition of NEDP1 promotes the disassembly of pathological stress granules (SGs) and improves cell survival. Deletion of nedp1 in C. elegans also ameliorates ALS phenotypes related to animal motility. These findings suggest that NEDP1 could be a potential therapeutic target for ALS.
Article
Genetics & Heredity
Minhee Kim, Keemo Delos Santos, Nam-Sung Moon
Summary: Polyploidy is a crucial process in development, associated with cellular stress, aging, and pathological conditions. The endocycle, which involves repeated G and S phases without mitosis, is regulated by E2F and plays a key role in producing polyploid cells. In Drosophila, an alternative isoform of de2f1, dE2F1b, is shown to control the expression of the Cdk inhibitor Dap and is required for proper CycE-Cdk2 activity during the endocycle. Additionally, dE2F1b is involved in establishing a negative feedback loop in S phase through regulating PCNA expression.
Article
Cell Biology
Tao Wang, Yu Zhou, Hui Bao, Bo Liu, Min Wang, Lei Wang, Tiejun Pan
Summary: The overexpression of MEF2A inhibits RCC progression through the modulation of Wnt/beta-catenin signaling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Dilyana Georgieva Kirova, Kristyna Judasova, Julia Vorhauser, Thomas Zerjatke, Jacky Kieran Leung, Ingmar Glauche, Joerg Mansfeld
Summary: Reactive oxygen species (ROS) play a role in regulating cell proliferation and DNA replication through modulating the activity of cyclin-dependent kinase 2 (CDK2). The increase in mitochondrial ROS levels during the cell cycle is shown to be important for regulating CDK2 activity through oxidation of a cysteine residue on CDK2.
DEVELOPMENTAL CELL
(2022)
Article
Neurosciences
Bo Cheng, Xiaoliang Hong, Linfang Wang, Yuanyuan Cao, Dengli Qin, Han Zhou, Dianshuai Gao
Summary: Curzerene inhibits the progression of glioma by suppressing the expression of GSTA4 and matrix metalloproteinase 9, and inhibiting the activation of the mTOR pathway. It also induces apoptosis and reduces invasion and migration of glioma cells. In vivo studies have shown that Curzerene significantly inhibits tumor growth and prolongs survival time.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Developmental Biology
Shaked Bar-Cohen, Mria Lorena Martinez Quiles, Alexey Baskin, Ruba Dawud, Barbara H. Jennings, Ze'ev Paroush
Summary: The cell cycle is regulated by the synthesis and degradation of phase-specific transcripts and proteins. Groucho, the orthologue of TLE1 in Drosophila, is shown to regulate normal cell cycle progression by selectively inactivating its activity through phosphorylation. This study suggests that Cdk1 is involved in phosphorylation of Groucho during the cell cycle, and Groucho may play a role in the development of human cancer.
Article
Chemistry, Multidisciplinary
Thomas Habets, Guillem Seychal, Marco Caliari, Jean-Marie Raquez, Haritz Sardon, Bruno Grignard, Christophe Detrembleur
Summary: Finding new chemistry platforms for easily recyclable polymers has become a key challenge to address environmental concerns and the growing plastics demand. This study reports a dynamic chemistry between CO2-sourced alkylidene oxazolidones and thiols, which enables the production of polymer networks with easily-tuned structures and multiple end-of-life scenarios. The polymer networks exhibit a wide range of mechanical properties similar to commodity plastics and can be recycled mechanically or chemically without degradation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Khalil Khashei Varnamkhasti, Mehdi Moghanibashi, Sirous Naeimi
Summary: Lymph node metastasis is a crucial factor in the prognosis of lung squamous cell carcinoma. This study aimed to identify potential prognostic biomarkers shared between primary tumors and lymphatic metastasis. A total of 397 differentially expressed genes were identified, and 56 of them showed significant correlation with reference genes, highlighting their potential for identifying lymph node metastasis in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2023)
Article
Optics
Lina Zhou, Yin Xiao, Wen Chen
Summary: Imaging with single-pixel detectors is a promising alternative when pixelated detectors are not available or feasible. This paper presents a self-corrected imaging method using dual single-pixel detectors to achieve high-resolution object reconstruction through dynamic and complex scattering media. The proposed method can overcome the challenges of dynamic scaling factors and mismatched probing patterns and realizations. Experimental results demonstrate the unprecedented robustness of the method against complex scattering, providing a solution for ghost recovery and enabling high-resolution object reconstruction in complex scattering environments.
Article
Cell Biology
Nicole J. Camlin, Ilakkiya Venkatachalam, Janice P. Evans
Summary: The protein phosphatase 1 (PP1) plays a crucial role in regulating M-phase transitions in mouse oocytes. The temporal control of PP1 activity is essential for various meiotic events, including the G2/M transition, metaphase I/anaphase I transition, and the alignment of metaphase II chromosomes. Loss of oscillations in PP1 activity leads to severe meiotic defects, highlighting the essential roles of PP1 in female fertility and M-phase regulation.
Article
Optics
Huazheng Wu, Xiangfeng Meng, Xiulun Yang, Xianye Li, Yongkai Yin
Summary: Low signal-to-noise ratio (SNR) measurement is the primary obstacle to real-time, high-resolution optical imaging through dynamic turbid media. By individualizing and employing low SNR measurement data, a noise model is procured for scatter imaging, leading to robustness in dealing with noise. Moreover, the deep correlography method outperforms existing Fourier-domain systems in terms of spatial resolution and total acquisition time.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Physics, Multidisciplinary
Syed Muhammad Arif, Bakht Amin Bacha, Umer Wahid, Arif Ullah, Muhammad Haneef
Summary: This study investigates the changes in absorption coefficients, refractive/group indices, phase shifts, and fractional change of birefringence beams through dynamic chiral atomic medium under the effect of quantum tunnelling. The birefringence of phase and group indices is controlled and modified through induced dynamic chiral medium by tunnelling effect, with reported group velocities and maximum change in birefringent phase shifts calculated. These results are important for scatterplate phase shifting interferometry.
Article
Multidisciplinary Sciences
Emilio Boada-Romero, Inmaculada Serramito-Gomez, Maria P. Sacristan, David L. Boone, Ramnik J. Xavier, Felipe X. Pimentel-Muinos
NATURE COMMUNICATIONS
(2016)
Article
Multidisciplinary Sciences
Sara Ovejero, Patricia Ayala, Marcos Malumbres, Felipe X. Pimentel-Muinos, Avelino Bueno, Maria P. Sacristan
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Khaled Hached, Perrine Goguet, Sophie Charrasse, Suzanne Vigneron, Maria P. Sacristan, Thierry Lorca, Anna Castro
JOURNAL OF CELL BIOLOGY
(2019)
Article
Genetics & Heredity
Eva Gomez-Orte, Beatriz Saenz-Narciso, Angelina Zheleva, Begona Ezcurra, Maria de Toro, Rosario Lopez, Irene Gastaca, Hilde Nilsen, Maria P. Sacristan, Ralf Schnabel, Juan Cabello
Article
Cell Biology
Vanesa Alvarez, Camilla Frattini, Maria P. Sacristan, Alfonso Gallego-Sanchez, Rodrigo Bermejo, Avelino Bueno
Review
Genetics & Heredity
Sara Ovejero, Avelino Bueno, Maria P. Sacristan
Article
Cell Biology
Vanesa Alvarez, Susanne Bandau, Hao Jiang, Diana Rios-Szwed, Jens Hukelmann, Elisa Garcia-Wilson, Nicola Wiechens, Eva Griesser, Sara Ten Have, Tom Owen-Hughes, Angus Lamond, Constance Alabert
Summary: During cell proliferation, chromatin organization needs to be maintained to preserve cellular identity and genome integrity. However, DNA replication displaces DNA-bound proteins temporarily, and it is unclear how they regain access to newly replicated DNA. Through quantitative proteomics, researchers provide time-resolved binding kinetics for thousands of proteins behind replisomes in different chromatin regions, revealing that most proteins regain access within minutes. However, 25% of the identified proteins show a delay in reassociation, influenced by chromatin organization and G1 phase entry, rather than their known function or abundance in the nucleus. Additionally, DNA replication not only disrupts but also promotes the recruitment of transcription factors and chromatin remodelers, leading to a better understanding of how DNA replication contributes to programmed changes in cell memory.
Article
Biochemistry & Molecular Biology
Cecile Evrin, Vanesa Alvarez, Johanna Ainsworth, Ryo Fujisawa, Constance Alabert, Karim P. M. Labib
Summary: DONSON plays an important role in the assembly of the CDC45-MCM-GINS helicase and is essential for chromosome duplication, providing a molecular explanation for its association with Meier-Gorlin syndrome.
Article
Biology
Diana Rios-Szwed, Vanesa Alvarez, Luis Sanchez-Pulido, Elisa Garcia-Wilson, Hao Jiang, Susanne Bandau, Angus Lamond, Constance Alabert
Summary: FAM111A is a replisome-associated protein that plays an important role in the activation of DNA replication origins. Dominant mutations within its trypsin-like peptidase domain are linked to severe human developmental syndrome. Research has shown that under normal conditions, FAM111A promotes DNA replication, but in a disease context, its unrestrained expression can lead to DNA damage and cell death.
LIFE SCIENCE ALLIANCE
(2023)