Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins

(2015) D. J. Colin et al.   Open Biology

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

(2013) Anthony J. Cesare et al.   MOLECULAR CELL

Linking abnormal mitosis to the acquisition of DNA damage

(2012) Neil J. Ganem et al.   JOURNAL OF CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

(2011) J. Shi et al.   CANCER RESEARCH

Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

(2011) Gabriela Imreh et al.   JOURNAL OF CELL SCIENCE

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

(2009) M. E. Bekier et al.   MOLECULAR CANCER THERAPEUTICS

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH