Article
Oncology
Yuanke Liang, Xiaoling Zhou, Qin Xie, Hexing Sun, Kaiyuan Huang, Huan Chen, Wende Wang, Benqing Zhou, Xiaolong Wei, De Zeng, Haoyu Lin
Summary: Radiotherapy is an essential treatment for breast cancer, but the resistance of tumors to radiation compromises its efficacy. This study demonstrates that CD146, highly expressed in triple-negative breast cancer, is induced by radiation and promotes tumor cell radioresistance both in vitro and in vivo. The underlying mechanism involves CD146 activating YAP protein and promoting its abnormal nuclear localization, inducing EMT and stemness, and enhancing DNA damage repair. Additionally, CD146 forms a co-receptor complex with integrin beta 1, further contributing to radiation resistance. Dual inhibition of CD146 and integrin beta 1 activity shows potential for overcoming radiotherapeutic resistance in breast cancer.
Article
Oncology
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben-Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M. Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L. Ho, Ari J. Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R. Grandis, J. Silvio Gutkind, Moshe Elkabets
Summary: The presence of mutated HRAS in head and neck cancer patients is associated with poor prognosis and high metastasis rate. Mutated HRAS promotes cancer cell invasion and metastasis by suppressing the Hippo pathway and promoting AXL expression. The use of tipifarnib, a farnesyltransferase inhibitor, can activate the Hippo pathway, suppress metastasis, and regulate angiogenesis in HNC.
Article
Biochemistry & Molecular Biology
Wendong Wang, Zhenzhen Liu, Xin Chen, Yongqu Lu, Bingyan Wang, Fei Li, Siyi Lu, Xin Zhou
Summary: FABP5 plays a crucial role in various cancers, with high expression associated with poor prognosis. Inhibition of FABP5 suppresses cell proliferation, migration, invasion, and induces apoptosis, and is related to the Hippo signaling pathway. Overexpression of YAP1 can partially reverse the effects of FABP5 knockdown on cell growth and apoptosis. The FABP5 inhibitor SBFI-26 suppresses proliferation, promotes apoptosis in gastric cancer cells, and interferes with the Hippo signaling pathway by inhibiting YAP1.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qifeng Sun, Hongda Lu, Wenjie Zhang, Yang Du, Qian Liang, Yehui Zhang, Jing Wu, Mingwei Zhong
Summary: This study reveals the oncogenic role of RNF106, a modifier of DNA methylation and histone ubiquitination, in esophageal squamous cell carcinoma (ESCC). It is found that RNF106 is involved in ESCC cell migration and invasion, and its expression is associated with poor survival in ESCC patients. Mechanistic studies demonstrate that RNF106 promotes YAP oncogenic function by regulating LATS2 ubiquitination and degradation in ESCC.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Oncology
Rui-zhen Cao, Li Min, Si Liu, Ru-yue Tian, Hai-yan Jiang, Juan Liu, Lin-lin Shao, Rui Cheng, Sheng-tao Zhu, Shui-long Guo, Peng Li
Summary: The study revealed that Rictor is upregulated in gastric cancer and associated with worse prognosis. It inhibits tumor cell apoptosis and activates Cav 1 through the Akt signaling pathway. Therefore, Rictor may serve as a potential prognostic biomarker and therapeutic target in gastric cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Summary: This study reveals the crucial role of YAP in breast cancer stem cells. Knockdown of YAP reduces the viability and stemness of BCSCs in vitro and tumor formation in vivo. IGF-1R and IGF-1 regulate the expression and localization of YAP, and YAP overexpression increases the expression of IGF-1. Clinical analysis shows that high levels of YAP and IGF-1 are associated with shorter overall survival in basal-like breast cancer patients. In conclusion, the interplay between YAP and the IGF-1/IGF-1R pathway is clinically relevant for sustaining the properties of BCSCs.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Oncology
Renya Zeng, Jixin Dong
Summary: Although major advancements have been made in cancer treatment, drug resistance remains a significant challenge. The Hippo signaling pathway is emerging as a key player in understanding how tumor cells develop resistance to anti-cancer drugs. This review highlights the role of the Hippo pathway in drug resistance and potential therapeutic interventions.
Review
Oncology
Srikanth Swamy B. Swaroop, Rahul Kanumuri, Inemai Ezhil, Jagadeesh Kumar Naidu Sampangi, Joachim Kremerskothen, Suresh Kumar Rayala, Ganesh Venkatraman
Summary: The Hippo signaling pathway is crucial in tissue homeostasis and organ size control, with KIBRA being an upstream regulator that can act as a tumor suppressor by positively regulating the pathway. However, evidence suggests that KIBRA may also have oncogenic functions, potentially due to its activities outside of the Hippo pathway. This review highlights the paradoxical role of KIBRA in cancer and provides new insights for cancer research.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Xiaochuan Dong, Shumei Song, Yuan Li, Yibo Fan, Lulu Wang, Ruiping Wang, Longfei Huo, Ailing Scott, Yan Xu, Melissa Pool Pizzi, Lang Ma, Ying Wang, Jiangkang Jin, Wei Zhao, Xiaodan Yao, Randy L. Johnson, Linghua Wang, Zhenning Wang, Guang Peng, Jaffer A. Ajani
Summary: Genetic alterations in ARID1A were found in over 30% of gastric adenocarcinoma cases, and the loss of ARID1A leads to activation of the mTOR pathway and increased sensitivity to mTOR inhibitors, suggesting a new therapeutic strategy for targeting the mTOR pathway in patients with gastric adenocarcinoma with ARID1A deficiency.
Article
Oncology
Lei Deng, Jun Zou, Yongfeng Su, Meijian Wang, Lianwu Zhao
Summary: This study found that resveratrol can inhibit the migration, invasion, and growth of gastric cancer cells. Further analysis revealed that it may inhibit epithelial-mesenchymal transition by affecting the Hippo-YAP signaling pathway.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Cell Biology
Lingsuo Kong, Wan Yang, Lanren Chen, Liting Qian
Summary: Studies have shown that drug-resistance is a major obstacle in the effective treatment of cancers, and the hypermethylation of the MCTP1 gene in drug-resistant esophageal cancer cells leads to its down-regulation, influencing cell migration and apoptosis. This suggests MCTP1 activates drug-resistance in esophageal cancer cells, indicating potential implications for the design of new biomarkers for esophageal cancer treatment.
Article
Pharmacology & Pharmacy
Yingchun Shao, Mengmeng Li, Qi Yu, Manyu Gong, Yanying Wang, Xuewen Yang, Liheng Liu, Dongping Liu, Zhongyue Tan, Yuanyuan Zhang, Yunmeng Qu, Haodong Li, Yaqi Wang, Lei Jiao, Ying Zhang
Summary: This study found that CDR1as is upregulated in diabetic cardiomyopathy (DCM), and knockdown of CDR1as can improve apoptosis caused by DCM. Mechanistically, CDR1as activates the Hippo signaling pathway by inhibiting MST1 ubiquitination level. Additionally, ALKBH5 activates FOXO3 through m6A demethylation and is involved in the regulation of CDR1as. Overall, this study reveals the important role of the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway in DCM and provides new insights into the critical role of m6A methylation in DCM.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wenli You, Aiting Di, Lize Zhang, Gang Zhao
Summary: Wogonin has been found to inhibit the survival and metastasis of colon cancer cells and suppress epithelial-mesenchymal transition. The study also revealed that Wogonin exerts its effects by reducing the protein expression of YAP1 and IRF3, and increasing p-YAP1 expression. Further experiments demonstrated that Wogonin relieves the carcinogenic behaviors and EMT of colon cancer cells through the IRF3-mediated Hippo signaling pathway.
Article
Multidisciplinary Sciences
Maria E. Gonzalez, Giuseppina Daniela Naimo, Talha Anwar, Alessandro Paoli, Shilpa R. Tekula, Suny Kim, Natasha Medhora, Shoshana A. Leflein, Jacob Itkin, Raymond Trievel, Kelley M. Kidwell, Yu-Chih Chen, Loredana Mauro, Euisik Yoon, Sebastiano Ando, Celina G. Kleer
Summary: This study uncovers the non-canonical function of EZH2 in promoting TNBC metastasis through phosphorylation at T367. It also reveals the ability of cytosolic EZH2 to methylate p38 alpha, enhancing its stability. Dual inhibition of EZH2 methyltransferase and p38 kinase activities can reduce TNBC growth and metastasis.
Article
Orthopedics
Mingming Yang, Hang Zhang, Shichang Gao, Wei Huang
Summary: This study aimed to explore the effect and mechanism of DEP domain 1 protein (DEPDC1) and kinesin super-family protein 4A (KIF4A) in osteosarcoma (OS). The down-regulation of DEPDC1 inhibited the malignant behavior of OS cells through the activation of Hippo signaling pathway, which could be partially reversed by upregulation of KIF4A.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Min Jung Kim, So-Young Rah, Jang-Hyun An, Kenji Kurokawa, Uh-Hyun Kim, Bok Luel Lee
Article
Multidisciplinary Sciences
Byung-Ju Kim, Yun-Min Choi, So-Young Rah, Dae-Ryoung Park, Seon-Ah Park, Yun-Jo Chung, Seung-Moon Park, Jong Kwan Park, Kyu Yun Jang, Uh-Hyun Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
So-Young Rah, Uh-Hyun Kim
SCIENTIFIC REPORTS
(2015)
Article
Neurosciences
Somi Kim, TaeHyun Kim, Hye-Ryeon Lee, Eun-Hye Jang, Hyun-Hee Ryu, Minkyung Kang, So-Young Rah, Juyoun Yoo, Bolam Lee, Jae-Ick Kim, Chae Seok Lim, Sang Jeong Kim, Uh-Hyun Kim, Yong-Seok Lee, Bong-Kiun Kaang
Article
Biochemistry & Molecular Biology
So-Young Rah, Young-Hoon Lee, Uh-Hyun Kim
Article
Immunology
Sun-Young Nam, Na-Ra Han, So-Young Rah, Youngwan Seo, Hyung-Min Kim, Hyun-Ja Jeong
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ka-Jung Ryu, Na-Rae Kim, So-Young Rah, Hyun-Ja Jeong, Hyung-Min Kim
JOURNAL OF FOOD BIOCHEMISTRY
(2017)
Article
Plant Sciences
Sun-Young Nam, Kyu-Yeob Kim, Mi Hye Kim, Jae-Bum Jang, So-Young Rah, Hee Jeong Chae, Jin-Man Lee, Hyung-Min Kim, Hyun-Ja Jeong
PHARMACEUTICAL BIOLOGY
(2017)
Article
Cell Biology
Hyo Jeong Kim, Yeonsoo Joe, So-Young Rah, Seul-Ki Kim, Se-Ung Park, Jeongmin Park, Jin Kim, Jinhyun Ryu, Gyeong Jae Cho, Young-Joon Surh, Stefan W. Ryter, Uh-Hyun Kim, Hun Taeg Chung
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung
Article
Biochemistry & Molecular Biology
Tae-Sik Nam, Dae-Ryoung Park, So-Young Rah, Tae-Gyu Woo, Hun Taeg Chung, Charles Brenner, Uh-Hyun Kim
Article
Biochemistry & Molecular Biology
Na-Ri Lee, Ruo Yu Meng, So-Young Rah, Hua Jin, Navin Ray, Seong-Hun Kim, Byung Hyun Park, Soo Mi Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Allergy
Hyun-Young Jang, Do Hyun Ha, So-Young Rah, Dong-Hyun Lee, Sang-Myeong Lee, Byung-Hyun Park
Summary: The study found that Sirt6 acts as a negative regulator of Fc epsilon RI signaling cascade in mast cells by suppressing PTPRC transcription. Activation of Sirt6 may represent a promising therapeutic strategy for anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Mihyang Do, Jeongmin Park, Yubing Chen, So-Young Rah, Thu-Hang Thi Nghiem, Jeong Heon Gong, Seong-A Ju, Byung-Sam Kim, Rina Yu, Jeong Woo Park, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, Yeonsoo Joe, Hun Taeg Chung
Summary: In this study, the activation of PERK was found to promote ALP activation, thereby alleviating amyloidogenesis in neurodegenerative diseases.