Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification

Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells

(2016) Hoi-Hin Kwok et al.   Scientific Reports

A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking

(2015) Hui-Peng Song et al.   CHEMICAL COMMUNICATIONS

Tools for in silico target fishing

(2015) Adrià Cereto-Massagué et al.   METHODS

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

(2015) Zhuhong Zhang et al.   Scientific Reports

A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines

(2015) Fang Long et al.   Scientific Reports

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins

(2015) An-Guo Wu et al.   Scientific Reports

Comparative Normal/Failing Rat Myocardium Cell Membrane Chromatographic Analysis System for Screening Specific Components That Counteract Doxorubicin-Induced Heart Failure from Acontium carmichaeli

(2014) Xiaofei Chen et al.   ANALYTICAL CHEMISTRY

Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk

(2014) Hongtao Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quality improvements of cell membrane chromatographic column

(2014) Xuan Ding et al.   JOURNAL OF CHROMATOGRAPHY A

TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

(2013) Lirong Wang et al.   AAPS Journal

Predicting drug penetration across the blood–brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography

(2013) Mike De Vrieze et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-small-cell lung cancer

(2013) Yi Wang et al.   CANCER LETTERS

Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and  -Catenin

(2013) S. M. Saud et al.   CANCER RESEARCH

Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2,3-Dioxygenase with Therapeutic Activity in Lewis Lung Cancer (LLC) Tumor-Bearing Mice

(2013) Shuangshuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Pharmacological tools for the development of traditional Chinese medicine

(2013) Xuan Liu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines

(2012) Xiaofei Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS

(2012) Huaizhen He et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

(2012) Sangkil Nam et al.   Molecular Oncology

Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro

(2011) Shan Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From in silico target prediction to multi-target drug design: Current databases, methods and applications

(2011) Alexios Koutsoukas et al.   Journal of Proteomics

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts

(2010) Y-C Lee et al.   ONCOGENE

A combined cell membrane chromatography and online HPLC/MS method for screening compounds from Radix Caulophylli acting on the human α1A-adrenoceptor

(2009) Lan Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis

(2008) Qiang Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Qualitative and quantitative analysis in quality control of traditional Chinese medicines

(2008) Xin-miao Liang et al.   JOURNAL OF CHROMATOGRAPHY A

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA