Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula

Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations

(2015) Zhiwei Feng et al.   Journal of Chemical Information and Modeling

The effects of modified sini decoction on liver injury and regeneration in acute liver failure induced by d-galactosamine in rats

(2015) Jianxing Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparative Pharmacokinetics of Hypaconitine after Oral Administration of Pure Hypaconitine, Aconitum carmichaelii Extract and Sini Decoction to Rats

(2015) Wen Zhang et al.   MOLECULES

Beware of docking!

(2015) Yu-Chian Chen   TRENDS IN PHARMACOLOGICAL SCIENCES

Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells

(2015) Yingdai Gao et al.   Nature Communications

Comparative pharmacokinetics of three monoester-diterpenoid alkaloids after oral administration ofAcontium carmichaeliextract and its compatibility with other herbal medicines in Sini Decoction to rats

(2014) Hai Zhang et al.   BIOMEDICAL CHROMATOGRAPHY

Network Pharmacology in Traditional Chinese Medicine

(2014) Shao Li et al.   Evidence-based Complementary and Alternative Medicine

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

(2014) Haibin Liu et al.   Journal of Chemical Information and Modeling

Absorption and metabolism of three monoester-diterpenoid alkaloids in Aconitum carmichaeli after oral administration to rats by HPLC–MS

(2014) Hai Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats

(2014) Shujing Sheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the therapeutic effectiveness of active components in Sini decoction by a comprehensive GC/LC-MS based metabolomics and network pharmacology approaches

(2014) Si Chen et al.   Molecular BioSystems

Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NF-κB Signaling Pathway

(2014) Chun Li et al.   PLoS One

In silico polypharmacology: retrospective recognition vs. rational design

(2014) Ewgenij Proschak   Journal of Cheminformatics

Chemogenomics knowledgebased polypharmacology analyses of drug abuse related G-protein coupled receptors and their ligands

(2014) Xiang-Qun Xie et al.   Frontiers in Pharmacology

Beyond the Circulating Renin–Angiotensin Aldosterone System

(2014) Walmor C. De Mello   Frontiers in Endocrinology

TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

(2013) Lirong Wang et al.   AAPS Journal

Renin–Angiotensin–Aldosterone System Inhibitors in Heart Failure

(2013) F Shearer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Economics of Polypharmacology: Fixed Dose Combinations and Drug Cocktails

(2013) A. I. Wertheimer   CURRENT MEDICINAL CHEMISTRY

Liquorice, a unique “guide drug” of traditional Chinese medicine: A review of its role in drug interactions

(2013) Xiaoying Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction

(2013) Yao Yao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis−Rhizoma Zingiberis

(2013) Wen-Wen Peng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives

(2013) Chun-Tao Che et al.   MOLECULES

Bioinformatics opportunities for identification and study of medicinal plants

(2012) V. Sharma et al.   BRIEFINGS IN BIOINFORMATICS

Metabonomic Profiles Delineate the Effect of Traditional Chinese Medicine Sini Decoction on Myocardial Infarction in Rats

(2012) Guangguo Tan et al.   PLoS One

Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)

(2012) Qifang Wu et al.   PLoS One

Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects

(2012) Katherine A. MacLean et al.   PSYCHOPHARMACOLOGY

A new model of congestive heart failure in rats

(2011) Jiqiu Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Proteopedia entry: HMG-CoA reductase

(2011) David Canner   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Detection and identification of diterpenoid alkaloids, isoflavonoids and saponins in Qifu decoction and rat plasma by liquid chromatography-time-of-flight mass spectrometry

(2011) Guangguo Tan et al.   BIOMEDICAL CHROMATOGRAPHY

Screening and analysis of aconitum alkaloids and their metabolites in rat urine after oral administration of aconite roots extract using LC-TOFMS-based metabolomics

(2011) Guangguo Tan et al.   BIOMEDICAL CHROMATOGRAPHY

Computational Polypharmacology with Text Mining and Ontologies

(2011) Conrad Plake et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Ligand Classifier of Adaptively Boosting Ensemble Decision Stumps (LiCABEDS) and Its Application on Modeling Ligand Functionality for 5HT-Subtype GPCR Families

(2011) Chao Ma et al.   Journal of Chemical Information and Modeling

GPU Accelerated Chemical Similarity Calculation for Compound Library Comparison

(2011) Chao Ma et al.   Journal of Chemical Information and Modeling

Hydrophilic interaction and reversed-phase ultraperformance liquid chromatographyTOF-MS for serum metabonomic analysis of myocardial infarction in rats and its applications

(2011) Guangguo Tan et al.   Molecular BioSystems

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

(2011) Tony Warne et al.   NATURE

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Compound Acquisition and Prioritization Algorithm for Constructing Structurally Diverse Compound Libraries

(2011) Chao Ma et al.   ACS Combinatorial Science

Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry

(2010) Guangguo Tan et al.   BIOMEDICAL CHROMATOGRAPHY

Polysaccharide from Fuzi (FPS) prevents hypercholesterolemia in rats

(2010) Xiongqing Huang et al.   Lipids in Health and Disease

Aconitum in Traditional Chinese Medicine—A valuable drug or an unpredictable risk?

(2009) Judith Singhuber et al.   JOURNAL OF ETHNOPHARMACOLOGY

Analysis of phenolic and triterpenoid compounds in licorice and rat plasma by high-performance liquid chromatography diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry

(2009) Guangguo Tan et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography–mass spectrometry

(2008) Jiangshan Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

(2008) Pál Pacher et al.   Nature Protocols