Article
Biochemistry & Molecular Biology
Cai Lu, Lu Fan, Peng-Fei Zhang, Wei-Wei Tao, Cheng-Bin Yang, Er-Xin Shang, Fei-Yan Chen, Chun-Tao Che, Hai-Bo Cheng, Jin-Ao Duan, Ming Zhao
Summary: The study demonstrated that bruceine A exhibits strong anti-proliferative activity against pancreatic cancer by directly binding to p38 alpha MAPK and affecting its phosphorylation, highlighting its potential as a novel lead compound for pancreatic cancer therapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Plant Sciences
Liping Chen, Di Feng, Yafang Qian, Xiao Cheng, Huizhu Song, Yifan Qian, Xu Zhang, Yali Wu, Huawei Lv, Qi Liu, Gang Cheng, Bo Yang, Mancang Gu
Summary: Valtrate exhibits anti-cancer activity against pancreatic cancer cells by directly targeting Stat3 through a covalent linkage to inhibit Stat3 activity, leading to apoptosis and cell cycle arrest.
Article
Microbiology
Dominik Arbon, Katerina Zeniskova, Karolina Subrtova, Jan Mach, Jan Stursa, Marta Machado, Farnaz Zahedifard, Tereza Lestinova, Carolina Hierro-Yap, Jiri Neuzil, Petr Volf, Markus Ganter, Martin Zoltner, Alena Zikova, Lukas Werner, Robert Sutak
Summary: Many existing anti-parasitic and anti-fungal drugs have limitations, so repurposing drugs with established clinical applications is an attractive approach. The study found that the anti-cancer drug candidate MitoTam efficiently eliminates a wide range of pathogens in vitro and in animal infection models. MitoTam disrupts mitochondrial functions and shows potential as a candidate drug.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Pengzhao Shang, Rui Gao, Yijia Zhu, Xiaorui Zhang, Yang Wang, Minji Guo, Hui Peng, Min Wang, Juan Zhang
Summary: A novel anti-VEGFR2-IFN alpha mutant protein was designed in this study to target VEGFR2, demonstrating specific inhibition of tumor cell proliferation, promotion of apoptosis, and suppression of migration and invasion of colorectal cancer cells through the PI3K-AKT-GSK3 beta-snail signaling pathway. This mutant protein also showed superior anti-tumor efficacy by enhancing dendritic cell maturation, activity, and increasing tumor-infiltrating CD8(+) T cells in the tumor microenvironment, providing a potential new approach to cancer immunotherapy.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Marine & Freshwater Biology
Hai-Shan Jiang, Li-Xia Lv, Jin-Xing Wang
Summary: Anti-lipopolysaccharide factors (ALFs) in shrimp exhibit strong antimicrobial activity against various microorganisms. A specific ALF, MjALF-D2, was found to have potent antiviral function against white spot syndrome virus (WSSV) in shrimp, suggesting its potential application for viral disease control in shrimp aquaculture.
MARINE LIFE SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Limei Zhang, Lihong Wu, Duanfang Zhou, Gang Wang, Bo Chen, Zhengze Shen, Xiaoli Li, Qiuya Wu, Na Qu, Yuanli Wu, Lie Yuan, Zongjie Gan, Weiying Zhou
Summary: Emerging evidence suggests that genetically highly specific triple-negative breast cancer (TNBC) is dependent on cyclin-dependent kinase 7 (CDK7). This study developed an inhibitor, N76-1, that targets CDK7 and investigates its role in TNBC. The results show that N76-1 inhibits TNBC cell viability, induces apoptosis and cell cycle arrest, and suppresses gene transcription and TNBC tumor growth.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ting Li, Guangfei Ge, Hanzi Zhang, Ruyue Wang, Yiyao Liu, Qian Zhang, Zhaorong Yue, Wuli Ma, Wenbo Li, Jingjing Zhang, Hui Yang, Peiya Wang, Jiang Zhao, Yanhao Fang, Qinjian Xie, Meizhu Wang, Yang Li, Hongmei Zhu, Hongyu Li
Summary: HM-3-HSA demonstrates antitumor activity against hepatocellular carcinoma and inhibits tumor angiogenesis by binding to HUVECs and suppressing downstream protein kinases. This study reveals the mechanism by which HM-3-HSA exerts its anti-angiogenic effects.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Kaiju Sun, Yangyang Du, Yuzhu Hou, Mingyue Zhao, Jiajia Li, Yazhe Du, Lingxiao Zhang, Changbao Chen, Hongmei Yang, Fei Yan, Rui Su
Summary: The study revealed that SsD has broad anti-proliferation effects in AML by targeting FTO/m(6)A signaling pathway, increasing global m(6)A RNA methylation levels, and suppressing relevant pathways affecting AML cell proliferation.
Article
Pharmacology & Pharmacy
Nanang Rudianto Ariefta, Baldorj Pagmadulam, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: This study evaluated the growth-inhibitory effects of the antimalarial agent sparsomycin against drug-resistant malaria parasites. The results showed that sparsomycin had inhibitory effects on both sensitive and resistant strains of the parasites. This study suggests that sparsomycin has potential as an alternative treatment for malaria.
Article
Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mervenur Yavuz, Turan Demircan
Summary: Despite advances in drug discovery, cancer remains a major global health problem. Ion channel modulators have been shown to have potential in suppressing tumor growth. Hydroquinidine, an underinvestigated potassium channel modulator, exhibits anti-carcinogenic activity.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Sreekumar Usha Devi Aiswarya, Gowda Vikas, Nair Hariprasad Haritha, Vijayasteltar Belsamma Liju, Anwar Shabna, Mundanattu Swetha, Tennyson Prakash Rayginia, Chenicheri Kizhakkeveettil Keerthana, Lekshmi Raghu Nath, Mullan Vellandy Reshma, Sankar Sundaram, Nikhil Ponnoor Anto, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha Vadakkeveettil Bava
Summary: This study reports the anti-cancer potential of the ethnomedicinal plant C. epigaeus and its bioactive derivative Cu-B against melanoma. Cu-B exhibited cytotoxic effects on melanoma cells while being less toxic to normal skin fibroblasts. In vivo studies showed that Cu-B attenuated tumor growth without apparent toxicity. The anti-melanoma activity of Cu-B was associated with the inhibition of MAPK signaling. These findings suggest that C. epigaeus-derived Cu-B could be a potential source for developing potent and safe anti-cancer compounds.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joelle Mesmar, Rola Abdallah, Kamar Hamade, Serine Baydoun, Najlaa Al-Thani, Abdullah Shaito, Marc Maresca, Adnan Badran, Elias Baydoun
Summary: Origanum syriacum L., a medicinal plant rich in bioactive compounds, shows promising anti-breast cancer effects against TNBC cells through inhibiting cell proliferation, inducing apoptosis, blocking cell cycle, and suppressing cell migration and invasion.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Virology
Sunitha Kodidela, Namita Sinha, Asit Kumar, Santosh Kumar
Summary: Chemodietary agent Cur-D demonstrates antiviral effects against HIV in vitro and reduces HIV replication induced by cigarette smoke condensate. By lowering viral load and levels of pro-inflammatory cytokine IL-1 beta, Cur-D could be a promising adjunct therapy for treating HIV and reducing neurotoxicity of existing antiretroviral drugs.
Article
Biochemistry & Molecular Biology
Ling Xu, Chao Wang, Wei Xu, Lixiao Xing, Jie Zhou, Jing Pu, Mingming Fu, Lu Lu, Shibo Jiang, Qian Wang
Summary: By replacing the PEG linker in EK1C4 with a short peptide, we designed and synthesized a dePEGylated lipopeptide, EKL1C, which showed potent inhibitory activity against coronaviruses, including SARS-CoV-2, and HIV-1. This indicates that HR1 may serve as a common target for the development of broad-spectrum viral fusion inhibitors, and EKL1C has potential clinical application as a therapeutic or preventive agent against coronavirus, HIV-1, and other class I enveloped viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Yahia N. Mabkhot, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, H. Algarni, Saied M. Soliman, Nabila A. Kheder, Hazem A. Ghabbour, Yahya I. Asiri, Mater H. Mahnash, Syed Tasqeeruddin, Syeda Shaheen Sulthana, Mohd. Zaheen Hassan
Summary: A novel bis(2-thienyl)disulfide derivative was synthesized through a reaction involving ethyl 3-oxobutanoate, carbon disulfide, and chloroacetone. The synthesized compound was characterized by spectral and X-ray analyses, and the results were confirmed using density functional theory calculations. Additionally, in silico studies were conducted to elucidate the inhibitory mechanism of the compound against dihydrofolate reductase.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Yahya I. Asiri, Kumar Venkatesan, Mohammed Al-Ghorbani, Yahia N. Mabkhot
Summary: A series of thiophene derivatives containing pyrazolo[3,4-d]pyridazine and pyridine moieties were synthesized and characterized. The synthesized compounds showed in vitro antimicrobial activity against various bacteria and fungi, with compounds 6 and 7 exhibiting the highest activity. Compound 6 demonstrated potent antibacterial activity against P. aeruginosa and moderate cytotoxic activity against the colon carcinoma cell line HCT-116.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Mohd Zaheen Hassan, Abdulrhman Alsayari, Yahya Asiri, Abdullatif Bin Muhsinah
Summary: Here, we describe an efficient synthesis method for novel benzothiazolyl-triazole compounds and discover that one derivative exhibits promising antifungal activity. Molecular docking studies were conducted to evaluate the binding mode of this compound with the target protein.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Yahia N. Mabkhot, Jamal M. A. Khaled, Naiyf S. H. A. Alharbi, Fahd Ali Nasr Mohammed, Fahd Abdo Almekhlafi, Nael Mahmmoud Abutaha, Nabila A. Kheder, Yahya I. Asiri, Abdullatif Bin Muhsinah, Abdulrhman Alsayari
Summary: This article describes the synthesis of a new thiazole derivative using a novel and economic synthetic route, which has antitumor, antimicrobial, and larvicidal properties. It is worth noting that the synthesized thiazole has been patented [US Patent No. 10,501,426 B1; date of patent: December 10, 2019].
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Yahya Asiri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Kumar Venkatesan, Mohammed Al-Ghorbani, Yahia N. Mabkhot
Summary: There is an urgent need for the development of new antimicrobial drugs to combat the emergence of antimicrobial-resistant microbes. A series of new thiophene derivatives were synthesized and tested for their antibacterial and antifungal activities. The compounds showed significant antibacterial activity against Gram-positive strains and strong antifungal activity. The results provide a foundation for the development of lead compounds with improved antimicrobial activities.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Yahya Asiri, Kumar Venkatesan, Yahia N. Mabkhot
Summary: The newly synthesized thiophene derivatives exhibit potent antibacterial and antifungal activities, with some compounds showing promising inhibition activity than the reference drugs. Compound 7 showed comparable cytotoxic activity to the clinically used anticancer agent doxorubicin against HCT-116 cell line.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Plant Sciences
Mohammad Khalid, Mohammed H. Alqarni, Abdulrhman Alsayari, Ahmed Foudah, Tariq M. Aljarba, Mohammad Mukim, Mubarak A. Alamri, Shahabe Saquib Abullais, Shadma Wahab
Summary: The study reveals that S. mangifera has antioxidant and anti-diabetic properties, suggesting its potential use as an anti-diabetic drug with antioxidant characteristics.
Article
Biochemistry & Molecular Biology
Mohammad Akhlaquer Rahman, Vineet Mittal, Shadma Wahab, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Dalia Almaghaslah
Summary: This study highlights the suitability of an oil-based nanocarrier for delivering quercetin and curcumin intravenously for the treatment of breast cancer. The nanoemulsion showed favorable characteristics such as small particle size, low polydispersity index, and suitable viscosity. In vitro experiments demonstrated the biocompatibility of the nanoemulsion with human blood and its cytotoxic potential against breast cancer cells, with a synergistic effect observed when both drugs were combined. The cellular uptake of the loaded nanoemulsion was significantly higher than that of the free drugs. Overall, this strategically designed nanoemulsion appears to be a promising drug delivery system for the development of quercetin and curcumin as therapeutic modalities for breast cancer treatment.
Article
Chemistry, Medicinal
Wasim Ahmad, Mohammad Azam Ansari, Abdulrhman Alsayari, Dalia Almaghaslah, Shadma Wahab, Mohammad N. Alomary, Qazi Mohammad Sajid Jamal, Firdos Alam Khan, Abuzer Ali, Prawez Alam, Abozer Y. Elderdery
Summary: In this study, anthraquinone derivatives chrysophanol (Chr) and emodin (EM) showed strong anti-cancer effects and had better binding energies than the FDA-approved anticancer drug fluorouracil, according to molecular docking studies. In vitro experiments confirmed the promising anticancer activity of Chr and EM in HCT-116 and HeLa cells, laying the foundation for their potential use in the treatment of human colorectal and cervical carcinomas.
Review
Nutrition & Dietetics
Taghreed A. A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. M. Alshahrani, Anas Shamsi, Akhtar Atiya
Summary: Cancer is a difficult-to-treat disease with a high reoccurrence rate that has a significant impact on global health and lives. Despite the availability of various drugs on the market against cancer, challenges of chemoresistance and side effects remain. Therefore, using complementary and additional medicines from natural sources is considered the best strategy to overcome these issues.
Article
Health Care Sciences & Services
Dalia Almaghaslah, Abdulrhman Alsayari
Summary: University students often seek academic help to improve their learning and complete courses. Peers, course online portals, and online educational resources are the most frequently used academic resources. While professors, teaching assistants, and textbooks are helpful, they are not frequently consulted for help.
Article
Health Care Sciences & Services
Dalia Almaghaslah, Abdulrhman Alsayari, Sokinh Almaghaslah, Haytham Alsanna
Summary: This study assessed patient satisfaction with the e-prescription service implemented by the Ministry of Health hospitals and primary healthcare centers in Saudi Arabia. The results showed that patients were highly satisfied with the accessibility, facilities, and staff of the pharmacies. They also had a positive experience with the new service compared to the old pharmaceutical services at primary healthcare centers.
Article
Nutrition & Dietetics
Abdulrhman Alsayari, Dalia Almaghaslah, Elham Almathami, Aljawharah Alsalem, Mohammad Zaitoun, Khalid Al-Alsheikh, Saleh Alyahya
Summary: Complementary and alternative medicine is widely used for disease self-management, and this study investigated its prevalence and types among end-stage renal disease patients receiving hemodialysis in the southern region of Saudi Arabia. The results showed that herbal remedies were the most commonly used modality, highlighting the importance of patient education and communication for understanding and managing potential risks.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Dalia Almaghaslah, Abdulrhman Alsayari, Rajalakshimi Lakshmi, Geetha Kandasamy, Sadia Batool, Easwaran Vigneshwaran, Asma A. Alshehri, Bayan A. Algamdi, Mona N. Alhattan, Shahad M. Alali
Summary: This study investigated the use, attitudes, and awareness of complementary and alternative medicine among adults in the Asir region of Saudi Arabia. The results showed that natural products, herbs, and religious/spiritual healing were commonly used in this region. The residents demonstrated a high level of awareness regarding complementary and alternative medicine, but there is a need for increased awareness in individuals using such therapies for progressive medical conditions.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Health Care Sciences & Services
Dalia Almaghaslah, Abdulrhman Alsayari
Summary: The current study aimed to evaluate academic advising services in a pharmacy college in Saudi Arabia and develop solutions to overcome the identified challenges. Using the design thinking method, several issues were identified with students, and prototypes were suggested to enhance their experiences in university life. These prototypes include a peer academic advising club, personal development workshop, and a series of lectures on college rules and regulations.
