FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription

Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

(2016) Zachary M. March et al.   BRAIN RESEARCH

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Subcellular localization and RNAs determine FUS architecture in different cellular compartments

(2015) Liuqing Yang et al.   HUMAN MOLECULAR GENETICS

Treatment with a Global Methyltransferase Inhibitor Induces the Intranuclear Aggregation of ALS-Linked FUS Mutant In Vitro

(2015) Sakiko Fujii et al.   NEUROCHEMICAL RESEARCH

FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP

(2015) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

(2015) Shuying Sun et al.   Nature Communications

Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation

(2014) Keisuke Takanashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

(2014) Janel O Johnson et al.   NATURE NEUROSCIENCE

Androgens affect muscle, motor neuron, and survival in a mouse model of SOD1-related amyotrophic lateral sclerosis

(2014) Tanya Aggarwal et al.   NEUROBIOLOGY OF AGING

Self-assembled FUS binds active chromatin and regulates gene transcription

(2014) Liuqing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

(2013) Ilmin Kwon et al.   CELL

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

(2013) Tatyana A. Shelkovnikova et al.   HUMAN MOLECULAR GENETICS

The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

(2013) Matthias Altmeyer et al.   MOLECULAR CELL

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2

(2013) N K Mukhopadhyay et al.   ONCOGENE

SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer

(2012) Elaine A. Hong et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA)

(2012) Haruhiko Banno et al.   CELL AND TISSUE RESEARCH

CAG repeat length in androgen receptor gene is not associated with amyotrophic lateral sclerosis

(2012) A. Bruson et al.   EUROPEAN JOURNAL OF NEUROLOGY

Relationship between DNA replication and the nuclear matrix

(2012) Rosemary H. C. Wilson et al.   GENES TO CELLS

Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα

(2012) Takashi Hashimoto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Effect of PRMT1-Mediated Arginine Methylation on the Subcellular Localization, Stress Granules, and Detergent-Insoluble Aggregates of FUS/TLS

(2012) Atsushi Yamaguchi et al.   PLoS One

Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)

(2012) Masahisa Katsuno et al.   PROGRESS IN NEUROBIOLOGY

Matrin 3 Binds and Stabilizes mRNA

(2011) Maayan Salton et al.   PLoS One

FUS/TLS Is a Co-Activator of Androgen Receptor in Prostate Cancer Cells

(2011) Simon Haile et al.   PLoS One

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

Metastatic choriocarcinoma

(2010) U. Vivekananda et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Drosophila SAF-B Links the Nuclear Matrix, Chromosomes, and Transcriptional Activity

(2010) Catalina Alfonso-Parra et al.   PLoS One

Matrin 3: Chromosomal distribution and protein interactions

(2009) Michael J. Zeitz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SAFB1's multiple functions in biological control-lots still to be done!

(2009) Jason P. Garee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Characterization of Cyclin L1 and L2 Interactions with CDK11 and Splicing Factors

(2008) Pascal Loyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE