Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 826-830Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120030
Keywords
cancer; scaffold attachment factor; transcription repression; tumour suppressor
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Funding
- Dr William Harker Foundation
- Overseas Research Students Awards Scheme
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SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in transcriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.
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