Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression

(2015) P. Jobling et al.   CANCER RESEARCH

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

(2015) Maher Hanoun et al.   NEURON

First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors

(2014) D. S. Hong et al.   INVESTIGATIONAL NEW DRUGS

PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

(2014) Yong Pan et al.   INVESTIGATIONAL NEW DRUGS

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

BDNF Mediates Neuroprotection against Oxygen-Glucose Deprivation by the Cardiac Glycoside Oleandrin

(2014) Michael J. Van Kanegan et al.   JOURNAL OF NEUROSCIENCE

Ursolic acid reduces oxidative stress to alleviate early brain injury following experimental subarachnoid hemorrhage

(2014) Tingting Zhang et al.   NEUROSCIENCE LETTERS

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

(2014) A. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives

(2013) Agnieszka Loboda et al.   Biomolecules & Therapeutics

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety

(2013) Robert J. Fox et al.   CURRENT MEDICAL RESEARCH AND OPINION

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dimethyl fumarate (BG-12) for the treatment of multiple sclerosis

(2013) Martin Stangel et al.   Expert Review of Clinical Pharmacology

Bardoxolone Brings Nrf2-Based Therapies to Light

(2012) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Pathophysiologic Cascades in Ischemic Stroke

(2012) Changhong Xing et al.   International Journal of Stroke

The immunology of neurodegeneration

(2012) Eva Czirr et al.   JOURNAL OF CLINICAL INVESTIGATION

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury

(2012) Feng Zhang et al.   STROKE

In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models

(2011) Denise E. Dunn et al.   JOURNAL OF NEUROCHEMISTRY

Understanding the link between cancer and neurodegeneration

(2011) Jane A. Driver   Journal of Geriatric Oncology

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

(2010) Hélène Plun-Favreau et al.   PLoS Genetics

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

(2008) Willeke MC van Roon-Mom et al.   BMC MOLECULAR BIOLOGY

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

The development of stroke therapeutics: Promising mechanisms and translational challenges

(2008) Margaret M. Zaleska et al.   NEUROPHARMACOLOGY