Article
Chemistry, Inorganic & Nuclear
Arunachalam Abirami, Umapathy Devan, Rengan Ramesh, Arockiam Antony Joseph Velanganni, Jan Grzegorz Malecki
Summary: This study synthesized six arene ruthenium(ii) complexes and evaluated their inhibitory effects on breast cancer cells. The complexes exhibited good antiproliferative activities by inducing apoptotic cell death through an intrinsic mitochondrial pathway.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Latis, Christoph Marschner, Judith Baumgartner, Sharon Prince, Supratim Biswas, Suparna Chakraborty, Kimberly G. Garcia, Ron M. A. Heeren, Sebastiaan Van Nuffel, Burgert Blom
Summary: This study reports the synthesis and characterisation of piano-stool triphenylstibine and triphenylarsine arene complexes, and their in vitro cytotoxic evaluation on breast cancer cell lines. The tin containing complexes demonstrate remarkable activity and selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begona Garcia, Fabio Marchetti
Summary: The study found that certain ruthenium complexes exhibited remarkable stability in water and cell culture medium, showing strong cytotoxicity against cancer cell lines, with RUCYN being the most promising one with significant selectivity compared to non-cancerous cells. The variability of affinity of the complexes for BSA and DNA binding was determined, with certain complexes showing enhanced cell internalization and cytotoxicity at the expense of selectivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Pawel Hikisz, Ewelina Namiecinska, Piotr Paneth, Elzbieta Budzisz
Summary: This study aims to investigate the biological aspects and anticancer activity of arene-ruthenium(II) complexes. Additional testing was conducted to better understand the potential mechanism of antitumor activity, including membrane permeability studies, ROS/RNS assays, and DNA analysis. Lipophilicity and molecular docking studies were also conducted. The presented data may have practical implications in cancer treatment.
Article
Biochemistry & Molecular Biology
Mathiyan Muralisankar, Jun-Ru Chen, Jebiti Haribabu, Shyue-Chu Ke
Summary: In this study, a series of water-soluble ruthenium-arene complexes were synthesized and characterized. Biophysical and chemical studies showed that these complexes have good anticancer activity. Cell experiments demonstrated that the complexes have stronger toxicity against bladder cancer cells compared to normal cells. This study provides new insights for the rational design of organoruthenium drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Catarina Teixeira-Guedes, Ana Rita Bras, Ricardo G. Teixeira, Andreia Valente, Ana Preto
Summary: This study evaluated the anti-cancer properties and mechanisms of action of ruthenium complexes in the treatment of colorectal cancer (CRC). The complexes displayed high bioactivity by reducing cell proliferation, inducing cell cycle arrest, increasing apoptosis, and inhibiting MEK/ERK and PI3K/AKT signaling pathways. The complexes also decreased cellular clonogenic ability and cell migration by disrupting F-actin cytoskeleton integrity, making them promising as a new therapeutic strategy for CRC treatment.
Article
Chemistry, Medicinal
Nazia Nayeem, Arefa Yeasmin, Samantha N. Cobos, Ali Younes, Karen Hubbard, Maria Contel
Summary: The study evaluated the effects of a water-soluble organometallic ruthenium compound Ru-IM (1) on TNBC cell lines derived from patients of European and African ancestry, showing high cytotoxicity and potential anti-metastatic and anti-angiogenic properties. The compound was found to inhibit protein expression of cytokine M-CSF involved in the PI3/AKT pathway, and demonstrated a p53-independent mechanism of action.
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Xuling Xue, Ying Fu, Liang He, Luca Salassa, Ling-Feng He, Yuan-Yuan Hao, Madeleine J. Koh, Clement Soulie, Russell J. Needham, Abraha Habtemariam, Claudio Garino, Kirill A. Lomachenko, Zhi Su, Yong Qian, Martin J. Paterson, Zong-Wan Mao, Hong-Ke Liu, Peter J. Sadler
Summary: Half-sandwich Os-arene complexes exhibit promising anticancer activity, especially the OsCUR-2 complex, which shows remarkable photocytotoxicity towards a range of cancer cell lines and has the potential for further development as a photosensitizer for anticancer photoactivated chemotherapy (PACT). The photochemistry of these complexes involves selective photodissociation of the arene ligand and oxidation of Os(II) to Os(III) under blue light or UVA excitation.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Russell J. Needham, Carlos Sanchez-Cano, Xin Zhang, Isolda Romero-Canelon, Abraha Habtemariam, Margaret S. Cooper, Levente Meszaros, Guy J. Clarkson, Philip J. Blower, Peter J. Sadler
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Inorganic & Nuclear
Hong-Yan Wang, Yong Qian, Fang-Xin Wang, Abraha Habtemariam, Zong-Wan Mao, Peter J. Sadler, Hong-Ke Liu
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Ana C. S. Gondim, Isolda Romero-Canelon, Eduardo H. S. Sousa, Claudia A. Blindauer, Jennifer S. Butler, Maria J. Romero, Carlos Sanchez-Cano, Bruno L. Sousa, Renata P. Chaves, Celso S. Nagano, Benildo S. Cavada, Peter J. Sadler
JOURNAL OF INORGANIC BIOCHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Asm Shihavuddin, Sreetama Basu, Elton Rexhepaj, Felipe Delestro, Nikita Menezes, Severine M. Sigoillot, Elaine Del Nery, Fekrije Selimi, Nathalie Spassky, Auguste Genovesio
NATURE COMMUNICATIONS
(2017)
Article
Chemistry, Inorganic & Nuclear
Feng Chen, Joan J. Soldevila-Barreda, Isolda Romero-Canelon, James P. C. Coverdale, Ji-Inn Song, Guy J. Clarkson, Jana Kasparkova, Abraha Habtemariam, Viktor Brabec, Juliusz A. Wolny, Volker Schuenemann, Peter J. Sadler
DALTON TRANSACTIONS
(2018)
Article
Chemistry, Multidisciplinary
James P. C. Coverdale, Isolda Romero-Canelon, Carlos Sanchez-Cano, Guy J. Clarkson, Abraha Habtemariam, Martin Wills, Peter J. Sadler
Article
Chemistry, Multidisciplinary
Samya Banerjee, Joan J. Soldevila-Barreda, Juliusz A. Wolny, Christopher A. Wootton, Abraha Habtemariam, Isolda Romero-Canelon, Feng Chen, Guy J. Clarkson, Ivan Prokes, Lijiang Song, Peter B. O'Connor, Volker Schuenemann, Peter J. Sadler
Article
Multidisciplinary Sciences
Alexia Mahuzier, Asm Shihavuddin, Clemence Fournier, Pauline Lansade, Marion Faucourt, Nikita Menezes, Alice Meunier, Meriem Garfa-Traore, Marie-France Carlier, Raphael Voituriez, Auguste Genovesio, Nathalie Spassky, Nathalie Delgehyr
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Inorganic & Nuclear
Maria J. Romero, Miguel Martinez-Calvo, Marcelino Maneiro, Guillermo Zaragoza, Rosa Pedrido, Ana M. Gonzalez-Noya
INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Feng Chen, Isolda Romero-Canelon, Abraha Habtemariam, Ji-Inn Song, Samya Banerjee, Guy J. Clarkson, Lijiang Song, Ivan Prokes, Peter J. Sadler
Summary: We synthesized a series of novel substituted sulfonyl ethylenediamine (en) Ru-II arene complexes, which showed antiproliferative activity against cancer cells and exhibited catalytic activity in transfer hydrogenation reactions and reactions with thiols.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Russell J. Needham, Ivan Prokes, Abraha Habtemariam, Isolda Romero-Canelon, Guy J. Clarkson, Peter J. Sadler
Summary: In this study, the synthesis and characterization of an organo-osmium anticancer complex, along with its potent activity against human ovarian cancer cells, were reported. The X-ray crystal structure confirmed the unique configuration of the complex, and analysis of the isotopically-enriched compound provided insights into its chemical shifts and bonding interactions.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Evyenia Shaili, Maria J. Romero, Luca Salassa, Julie A. Woods, Jennifer S. Butler, Isolda Romero-Canelon, Guy Clarkson, Abraha Habtemariam, Peter J. Sadler, Nicola J. Farrer
Summary: The synthesis and characterization of four platinum complexes were conducted and analyzed using various methods. Complexes 1-3 demonstrated phototoxicity under green light irradiation, with complexes 1 and 2 exhibiting higher photocytotoxicity and activity against cisplatin-resistant cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Abraha Habtemariam, Ana M. Pizarro
Summary: This study introduces a new family of osmium arene complexes and investigates their mechanism of action inside cells. The complexes are shown to catalyze the conversion of organic substrates, demonstrating potential anti-cancer drug activity.
Article
Chemistry, Multidisciplinary
Pingyu Zhang, Cookson K. C. Chiu, Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O'Connor, Hui Chao, Peter J. Sadler
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Maria J. Romero, Vanesa Suarez, Sandra Fernandez-Farina, Marcelino Maneiro, Emilio Martinez-Nunez, Guillermo Zaragoza, Ana M. Gonzalez-Noya, Rosa Pedrido
CHEMISTRY-A EUROPEAN JOURNAL
(2017)