Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

In-Cell Activation of Organo-Osmium(II) Anticancer Complexes

(2016) Russell J. Needham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The mechanism of enantioselective ketone reduction with Noyori and Noyori–Ikariya bifunctional catalysts

(2016) Pavel A. Dub et al.   DALTON TRANSACTIONS

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Transition metal catalysis in the mitochondria of living cells

(2016) María Tomás-Gamasa et al.   Nature Communications

Efficient In Situ Regeneration of NADH Mimics by an Artificial Metalloenzyme

(2016) Yasunori Okamoto et al.   ACS Catalysis

Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System

(2015) Hsiao-Tieh Hsu et al.   BIOCONJUGATE CHEMISTRY

Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts

(2015) James P. C. Coverdale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Half-sandwich rhodium(III) transfer hydrogenation catalysts: Reduction of NAD + and pyruvate, and antiproliferative activity

(2015) Joan J. Soldevila-Barreda et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

(2015) Joan J. Soldevila-Barreda et al.   Nature Communications

Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G-Quadruplex Telomeric DNA by an Anticancer Copper-Acridine-ATCUN Complex

(2014) Zhen Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

(2014) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metallodrugs in Medicinal Inorganic Chemistry

(2014) Katja Dralle Mjos et al.   CHEMICAL REVIEWS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preparation of Both C5′ Epimers of 5′-C-Methyladenosine: Reagent Control Trumps Substrate Control

(2014) Cavan M. Bligh et al.   JOURNAL OF ORGANIC CHEMISTRY

Pharmacopeial requirements for elemental impurities: a novel approach to the trace determination of osmium by oxidative pressure vessel sample digestion and measurement using inductively coupled plasma mass spectrometry (ICP-MS) after complexation and stabilisation

(2013) Cornel Venzago et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantum Chemical Calculations with the Inclusion of Nonspecific and Specific Solvation: Asymmetric Transfer Hydrogenation with Bifunctional Ruthenium Catalysts

(2013) Pavel A. Dub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal complex catalysis in living biological systems

(2012) Pijus K. Sasmal et al.   CHEMICAL COMMUNICATIONS

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

(2012) Binbing Ling et al.   Nutrition & Metabolism

The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes

(2012) Ying Fu et al.   Chemical Science

Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines

(2011) Marc Dürrenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Organometallic Half-Sandwich Iridium Anticancer Complexes

(2011) Zhe Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The organotelluride catalyst LAB027 prevents colon cancer growth in the mice

(2011) R Coriat et al.   Cell Death & Disease

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Artificial Metalloenzymes Based on the Biotin−Avidin Technology: Enantioselective Catalysis and Beyond

(2010) Thomas R. Ward   ACCOUNTS OF CHEMICAL RESEARCH

Hydrolysis of cisplatin—a first-principles metadynamics study

(2010) Justin Kai-Chi Lau et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

(2009) Michael I. Koukourakis et al.   ONCOLOGY

Catalytic organometallic anticancer complexes

(2008) S. J. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA