Article
Biophysics
Sharon Rose Pamshong, Dhananjay Bhatane, Santosh Sarnaik, Amit Alexander
Summary: Proteins and peptides (PPs) have advantages as therapeutics, but their effective delivery and bioavailability are challenging due to their large size and susceptibility to environmental conditions. Nanoparticle-based delivery systems, such as mesoporous silica nanoparticles (MSNs), show potential for protecting and delivering PPs to the target site.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Khatereh Zarkesh, Reza Heidari, Pooya Iranpour, Negar Azarpira, Fatemeh Ahmadi, Soliman Mohammadi-Samani, Fatemeh Farjadian
Summary: This study successfully synthesized a novel pH-responsive mesoporous silica nanoparticle and achieved targeted drug delivery to cancer cells by coating with hyaluronan. The results showed that the nanoparticles had good biocompatibility and biodegradability, and could improve pharmacokinetic parameters.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Polymer Science
Lisa Efriani Puluhulawa, I. Made Joni, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Muchtaridi Muchtaridi, Nasrul Wathoni
Summary: Chitosan-hyaluronic acid nanoparticles have the potential to be an effective and targeted treatment for various types of cancer, with good characteristics and active targeting capabilities.
Article
Nanoscience & Nanotechnology
Xiaojing Yang, Di-Feng Chen, Lin-Song Li, Xue-Jie Zhao, Mei-Xia Zhao
Summary: The study developed a nanodrug carrier for targeted drug delivery, which showed strong cytotoxicity towards colorectal cancer cells and targeted mitochondria, generating reactive oxygen species.
Review
Chemistry, Multidisciplinary
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin, Alexander Seifalian
Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen
Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.
Review
Biochemistry & Molecular Biology
Ying Kuang, Junjun Zhai, Qinjian Xiao, Si Zhao, Cao Li
Summary: Mesoporous silica nanoparticles (MSNs) play a significant role in drug delivery systems, and natural polysaccharides are widely used as gate materials, providing good biocompatibility and important biological functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Zhi-Yuan Wu, Zui-Harng Lee, Yu-Ya Huang, Min-Hsuan Tsou, Hsiu-Mei Lin
Summary: Traditional treatment of cancers such as chemotherapy still causes side effects. Combination therapies using drug delivery systems are valued. By doping lanthanide ions into the structure, mesoporous silica nanoparticles (MSNs) can have photodynamic therapy function and dual imaging functions. Doxorubicin was loaded into the MSNs, and hyaluronic acid was bonded on the surface. A drug delivery system with dual-imaging activity for chemo-photodynamic therapy was synthesized.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Genyang Ye, Tianlong Wu, Zhaohua Li, Manlin Teng, Lixue Ma, Mengdi Qin, Peixu Zhao, Qiang Fu
Summary: In this study, hyaluronic acid (HA) was used to improve the delivery efficiency of naringenin (NAR) by loading it into zein nanoparticles. The optimized Nar/zein-HA nanoparticles had uniform spherical shape with desirable particle size, polydispersity index, and zeta-potential. The microstructure of the nanoparticles was maintained by hydrophobic, electrostatic, and hydrogen-bonding interactions. Furthermore, the nanoparticles showed favorable physical stability, enhanced encapsulation efficiency, improved antioxidant capacity, and release in simulated gastrointestinal digestion of Nar.
Article
Chemistry, Physical
Jun Xu, Gaoyang Li, Yuhua Zhang, Yuhan Kang, Shouhong Xu, Honglai Liu
Summary: This study prepared a thermo/redox dual responsive drug carrier based on MSNs by grafting a zipper-type peptide onto the surface, which could block and release the drug. Experimental results demonstrated the excellent controllability of drug release by the nanovalve system, and the good cytocompatibility and cell recognition of the nanocarriers.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Sepanta Hosseinpour, Maria Natividad Gomez-Cerezo, Yuxue Cao, Chang Lei, Huan Dai, Laurence J. Walsh, Saso Ivanovski, Chun Xu
Summary: This study compared the capacity of mesoporous bioactive glass nanoparticles and mesoporous silica nanoparticles to deliver miRNA to bone marrow mesenchymal stem cells, demonstrating that mesoporous bioactive glass nanoparticles had a stronger osteogenic effect.
Article
Chemistry, Multidisciplinary
Donghun Shin, Seungki Lee, Hyun Sung Jang, Ji Bong Joo, Inhee Choi
Summary: In this study, dual-responsive hollow mesoporous silica nanoparticles (HMSNs) capped with hyaluronic acid (HA) were designed as drug carriers, exhibiting enhanced targeting efficiency and drug release efficiency. This research provides a new possibility for further improving drug delivery efficiency.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Su-Hwan Kim, Kwangsoo Shin, Byung-Gee Kim, Nathaniel S. S. Hwang, Taeghwan Hyeon
Summary: The combination of mesoporous silica nanoparticles (MSNs) and tyrosinase enables immediate adhesion and long-term sustainability of biological tissues, making it a promising strategy for tissue adhesives in clinical settings.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qinghong Hou, Lulu Wang, Feng Xiao, Le Wang, Xiaoyan Liu, Lina Zhu, Yi Lu, Wenfu Zheng, Xingyu Jiang
Summary: A double targeting nanoparticle carrying lamotrigine has been designed to cross the blood-brain barrier and concentrate at the neurons, providing a new strategy for improving the therapeutic efficacy of existing antiepileptic drugs.
Article
Chemistry, Multidisciplinary
Jannik Paulus, Beate Nachtigall, Peter Meyer, Norbert Sewald
Summary: A library of sulfonamide-modified RGD mimetics with high affinity for integrin alpha(V)beta(3) was synthesized. The best structure was selected and conjugated with a cleavable linker and the drug MMAE to form a SMDC. The resulting SMDC showed high affinity and selectivity for alpha(V)beta(3).
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
