Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Analytical
Yanan Hou, Rui Han, Yuanling Sun, Chuannan Luo, Xueying Wang
Summary: This article proposes a method for detecting tumor markers using DNA cross-linked hydrogel-capped magnetic core-shell structure mesoporous silica nanoparticles (Fe3O4@nSiO2@mSiO2). The method is highly sensitive and selective, allowing for the detection of low concentrations of adenosine under low background light conditions.
ANALYTICA CHIMICA ACTA
(2022)
Article
Materials Science, Ceramics
Langston Tillman, Albert Voskanyan, Alexandra Navrotsky
Summary: This study successfully synthesized mesoporous silica with an average pore size of 10 nm using forsterite as a silica source, providing a potentially cheaper and more environmentally friendly route to making technologically important porous silica materials.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Blanca de Juan Mora, Luis Filipe, Andreia Forte, Miguel M. Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luis C. Branco, Sandra Gago
Summary: In this study, two nanomaterials based on mesoporous silica nanoparticles immobilized with ciprofloxacin were prepared and characterized for their structures and antimicrobial activities. The nanomaterials showed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae, with higher activity than the precursor and neutral ciprofloxacin.
Article
Pharmacology & Pharmacy
Pedro Martins da Silva Filho, Pedro Higor Rocha Mariano, Alexandre Lopes Andrade, Jessica Barros Arrais Cruz Lopes, Aryane de Azevedo Pinheiro, Mayara Itala Geronimo de Azevedo, Suelen Carneiro de Medeiros, Mayron Alves de Vasconcelos, Said Goncalvez da Cruz Fonseca, Thalles Barbosa Grangeiro, Luiz Gonzaga de Franca, Eduardo Henrique Silva Sousa, Edson Holanda Teixeira, Elisane Longhinotti
Summary: New antibiotic agents are urgently needed worldwide to combat the increasing tolerance and resistance of pathogenic fungi and bacteria to current antimicrobials. The study found that minor quantities of cetyltrimethylammonium bromide (CTAB) on silica nanoparticles exhibit antimicrobial activity against Methicillin-resistant Staphylococcus aureus strain and reference strains of Candida. The results also showed low cytotoxicity in human fibroblasts and potential application in the treatment and/or prevention of infections caused by drug-resistant Staphylococcus and Candida species.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Seyed Reza Heydari, Mohammad Hossein Ghahremani, Fatemeh Atyabi, Reza Bafkary, Mahmoud Reza Jaafari, Rassoul Dinarvand
Summary: In this study, surface modified mesoporous silica nanoparticles were prepared for targeted delivery of anticancer agents. Their suitability was demonstrated through in vitro and in vivo experiments, showing improved drug release and anticancer activity compared to unmodified nanoparticles. Moreover, the interaction between aptamer and receptor enhanced the uptake of nanoparticles by cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mengru Chen, Yunyun Chen, Yanbao Zhao, Xueyan Zou, Lei Sun
Summary: In this study, three types of mesoporous silica nanoparticles with different aspect ratios were prepared. The samples showed that aspect ratio affects specific surface area, cell uptake rate, and drug loading capacity. The MS3 sample, with higher cell uptake rate and specific surface area, was used as a carrier for drug delivery system, displaying redox/pH-responsive and sustained release behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mitra Torabi, Ayuob Aghanejad, Pouria Savadi, Abolfazl Barzegari, Yadollah Omidi, Jaleh Barar
Summary: Magnetic mesoporous silica nanoparticles (MMSNPs) have been developed as multifunctional drug delivery systems for targeted therapy. Magnetic cores were synthesized using the thermal decomposition method, and mesoporous silica was coated onto the cores to enhance biocompatibility. Sunitinib (SUN) was loaded into the MMSNPs and MUC-1 aptamers were attached to the particles. Characterization studies showed that the engineered MMSNPs had a smooth surface, spherical shape, and an average size of 97.6 nm. Biological analysis demonstrated that the targeted MMSNPs had the greatest impact on MUC-1 overexpressing cells compared to MUC-1 negative cells. In conclusion, the synthesized MMSNP-SUN-MUC-1 nanosystem is a unique multifunctional targeted delivery system for ovarian cancer cells that overexpress MUC-1.
Article
Chemistry, Multidisciplinary
Carmen Racles, Mirela-Fernanda Zaltariov, Dragos Peptanariu, Tudor Vasiliu, Maria Cazacu
Summary: Mesoporous silica nanoparticles (MSNs) with different functional groups were synthesized and investigated for the encapsulation and release of anticancer drug Doxorubicin (Dox). The results showed that MSNs with thiol and glucose groups had high loading efficiency and high release rates at pH 5. In vitro experiments demonstrated strong cytotoxic effects of these loaded silica nanoparticles on cancer cells.
Article
Biophysics
Sandra Montalvo-Quiros, Sergio Gomez-Grana, Maria Vallet-Regi, Rafael C. Prados-Rosales, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: Tuberculosis remains a major public health issue with a lack of effective vaccine and the emergence of highly antibiotic-resistant strains of Mycobacterium tuberculosis. Silver nanoparticles show high bactericidal efficacy, but their relatively high toxicity calls for the design of nanocarriers for safe delivery. Mesoporous silica nanoparticles have been used as carriers for silver nanoparticles as antimycobacterial agents, demonstrating good capability against Mtb with different synthetic approaches.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Seyed Reza Heydari, Mahnoush Samadi, Armina Shirangi, Mehdi Farokhi, Ayda Moradi, Reza Bafkary, Fatemeh Atyabi, Fatemeh Mottaghitalab, Rassoul Dinarvand
Summary: In this study, dual responsive mesoporous silica nanoparticles (MSNs) were designed to effectively deliver PB to osteosarcoma cancer cells. PB loaded MSNs showed higher drug release in the tumor microenvironment and enhanced cytotoxicity against cancer cells. This study provides a promising method for osteosarcoma treatment using PB loaded MSNs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Monica Paesa, Fernando Almazan, Cristina Yus, Victor Sebastian, Manuel Arruebo, Luis M. Gandia, Santiago Reinoso, Ismael Pellejero, Gracia Mendoza
Summary: This study investigates the antimicrobial performance of polyoxometalate-stabilized gold nanoparticles against Escherichia coli and Staphylococcus aureus, finding that one particular composite exhibits excellent bactericidal efficiency without harming mammalian cells.
Article
Chemistry, Physical
Danhua Xie, Yulong Jiang, Binglei Song, Xueying Yang
Summary: Switchable base/acid Pickering foams stabilized by mesoporous silica nanoparticles and a pH-insensitive cationic Gemini surfactant were prepared. These foams showed favorable stability and high salt resistance, and exhibited rapid response to added NaOH solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Yujiro Watanabe, Naoki Amitani, Takushi Yokoyama, Akira Ueda, Minoru Kusakabe, Shigeko Unami, Yoshiji Odashima
Summary: Mesoporous silica was successfully synthesized using geothermal water from the Onuma Geothermal Power Plant in Japan for the first time. Cetyltrimethylammonium bromide (CTAB) was used as an organic template for the synthesis, resulting in efficient recovery of supersaturated silicic acid from the geothermal water. The monosilicic acid in geothermal water plays a crucial role in the formation of mesoporous silica, which can contribute to preventing silica scale formation in geothermal power plant piping systems and serve as an industrial resource.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Manuel Perez-Garnes, Victoria Morales, Raul Sanz, Rafael A. Garcia-Munoz
Summary: Hollow-shell mesoporous silica nanoparticles encapsulating iron oxide were prepared using a drug-structure-directing agent concept, showing potential for theranostic applications. These nanoparticles can load and release drugs to specific target cells, overcoming limitations of conventional formulations in reaching desired sites.
Article
Polymer Science
Mustafa Sengor, Alp Ozgun, Gulcan Corapcioglu, Mehmet Ipekoglu, Bora Garipcan, Nuri Ersoy, Sabri Altintas
JOURNAL OF APPLIED POLYMER SCIENCE
(2018)
Article
Engineering, Biomedical
Gamze Bolukbasi Ates, Ayse Ak, Bora Garipcan, Murat Gulsoy
LASERS IN MEDICAL SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Pelin Toren, Erol Ozgur, Mehmet Bayindir
Article
Nanoscience & Nanotechnology
Adem Yildirim, Dennis Shi, Shambojit Roy, Nicholas T. Blum, Rajarshi Chattaraj, Jennifer N. Cha, Andrew P. Goodwin
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Multidisciplinary Sciences
Gunnur Onak, Mustafa Sen, Nesrin Horzum, Utku Kursat Ercan, Ziysan Buse Yarali, Bora Garipcan, Ozan Karaman
SCIENTIFIC REPORTS
(2018)
Article
Nanoscience & Nanotechnology
Nicholas T. Blum, Adem Yildirim, Ciara Gyorkos, Dennis Shi, Angela Cai, Rajarshi Chattaraj, Andrew P. Goodwin
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Clinical Neurology
Alp Ozgun, Ana Marotez, Leo A. Behie, Antonio Salgadoz, Bora Garipcan
JOURNAL OF NEURAL TRANSMISSION
(2019)
Article
Biotechnology & Applied Microbiology
Gamze Bolukbasi Ates, Ayse Ak, Bora Garipcan, Murat Gulsoy
Article
Chemistry, Multidisciplinary
Jose Montoya Mira, Lucy Wu, Sinan Sabuncu, Ajay Sapre, Fehmi Civitci, Stuart Ibsen, Sadik Esener, Adem Yildirim
Review
Nanoscience & Nanotechnology
Sinan Sabuncu, Adem Yildirim
Summary: Ultrasound has long been used in the clinic for cancer detection and therapy, with stabilized fluorocarbon microbubbles as contrast agents. However, the limitations of microbubbles in terms of size, stability, and cavitation activity have led to the exploration of gas-stabilizing nanoparticles as an alternative material for improved methods in molecular ultrasound imaging and cancer therapy.
Article
Chemistry, Multidisciplinary
Sinan Sabuncu, Ruth Javier Ramirez, Jared M. Fischer, Fehmi Civitci, Adem Yildirim
Summary: Localization-based ultrasound imaging methods using microbubbles or nanodroplets provide high-resolution images with reduced background signal, but suffer from long acquisition times. A new ultrafast localization method using blinking ultrasound-responsive nanoparticles (BNPs) is introduced, enabling background-free ultrasound images with acquisition times as low as 11 ms. In vivo background-free ultrasound imaging in mice is also demonstrated with the use of BNPs, suggesting its potential for more sensitive detection of cancer and other diseases.
Article
Chemistry, Multidisciplinary
Sinan Sabuncu, Jose Montoya Mira, Arnaud Quentel, Michelle M. M. Gomes, Fehmi Civitci, Jared M. M. Fischer, Adem Yildirim
Summary: This study presents the development of biodegradable hydrophobic nanoparticles that can stabilize small gas pockets for ultrasound therapeutics. The nanoparticles can rapidly degrade in simulated body fluid or in vivo, while retaining strong cavitation activity. They can be used to ablate tumors at lower ultrasound intensities and enrich circulating tumor DNA for improved liquid biopsies.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Essam Hamied Ahmed Hanashalshahaby, Canan Unaleroglu, Ayse A. K. Can, Alp Ozgun, Bora Garipcan
TURKISH JOURNAL OF CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Adem Yildirim, Nicholas T. Blum, Andrew P. Goodwin
Proceedings Paper
Engineering, Biomedical
Fatma Gulden Simsek, Bora Garipcan, Yekta Ulgen
2017 21ST NATIONAL BIOMEDICAL ENGINEERING MEETING (BIYOMUT)
(2017)