Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications

(2015) Mayaka Maeno et al.   Chemical Science

Steady-State Plasma Concentration of Donepezil Enantiomers and Its Stereoselective Metabolism and Transport In Vitro

(2013) Wan Lili et al.   CHIRALITY

Conformational Analysis and Parallel QM/MM X-ray Refinement of Protein Bound Anti-Alzheimer Drug Donepezil

(2013) Zheng Fu et al.   Journal of Chemical Theory and Computation

Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles

(2012) Kalicharan Chattopadhyay et al.   Beilstein Journal of Organic Chemistry

Self-disproportionation of enantiomers via achiral chromatography: a warning and an extra dimension in optical purifications

(2012) Vadim A. Soloshonok et al.   CHEMICAL SOCIETY REVIEWS

Transition Metal-Catalyzed Decarboxylative Allylation and Benzylation Reactions

(2011) Jimmie D. Weaver et al.   CHEMICAL REVIEWS

Asymmetric Synthesis of Both Mirror Images of 3′-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid

(2010) Takeshi Yamamoto et al.   ORGANIC LETTERS

Donepezil-Induced Adverse Side Effects of Cardiac Rhythm: 2 Cases Report of Atrioventricular Block and Torsade de Pointes

(2009) Atsushi Tanaka et al.   INTERNAL MEDICINE

Unexpected effect of the fluorine atom on the optimal ligand-to-palladium ratio in the enantioselective Pd-catalyzed allylation reaction of fluorinated enol carbonates

(2008) Étienne Bélanger et al.   CHEMICAL COMMUNICATIONS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS