Article
Obstetrics & Gynecology
Ting Xiong, Yuanjue Wu, Li Huang, Xi Chen, Yu Zhang, Chunrong Zhong, Qin Gao, Miao Hong, Xingwen Hu, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: This study aimed to investigate the association between maternal serum albumin (MAlb) levels and fetal growth as well as the risk of fetal growth restriction (FGR). The findings revealed a reverse U-shaped relationship between MAlb and fetal growth, indicating an increased risk of FGR when MAlb levels were either too low or too high. These findings are important for understanding the relationship between maternal serum albumin and fetal health.
FERTILITY AND STERILITY
(2022)
Article
Pediatrics
Cynthia Schreiner, Theresa L. Powell, Claire Palmer, Thomas Jansson
Summary: This study examines the proteins in the umbilical vein and artery of preterm infants and highlights the importance of placental factors in fetal organ development. The findings suggest that the secretion of certain proteins from the placenta decreases after birth, potentially affecting brain and lung development.
PEDIATRIC RESEARCH
(2022)
Article
Immunology
Sarah U. Morton, Maureen Schnur, Rylee Kerper, Vanessa Young, Amy E. O'Connell
Summary: Premature infants have immature immune systems compared to term infants. This study used T cell receptor sequencing to analyze the T cell composition in premature and term infants, and found that premature infants demonstrate normal maturation of the T cell repertoire ex utero.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Angelos Dimas, Anastasia Politi, Alexandra Bargiota, Theodoros Panoskaltsis, Nikolaos F. Vlahos, Georgios Valsamakis
Summary: Fetal exposure to adverse environmental factors during intrauterine life can affect the development and future metabolic health of the offspring. Maternal bone turnover is implicated in fetal growth and neonatal body composition and metabolic wellbeing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Michelle C. Starr, Robert H. Schmicker, Brian A. Halloran, Patrick Heagerty, Patrick Brophy, Stuart L. Goldstein, Sandra E. Juul, Sangeeta Hingorani, David J. Askenazi, ENUT Trial Consortium
Summary: Despite advances in understanding and managing bronchopulmonary dysplasia (BPD), its rates remain stable. There is mounting evidence that suggests BPD may be linked to systemic insults like acute kidney injury (AKI). This study aimed to investigate the association between severe AKI and BPD, as well as explore urinary biomarkers for BPD prediction.
PEDIATRIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Calvin Q. Pan, Erhei Dai, Zhongping Duan, Guorong Han, Wenjing Zhao, Yuming Wang, Huaihong Zhang, Baoshen Zhu, Hongxiu Jiang, Shuqin Zhang, Xiaohu Zhang, Huaibin Zou, Xiuli Chen, Yu Chen
Summary: The study found that infants exposed to TDF during fetal development had normal physical growth, bone mineral density, and neurodevelopment at 192 weeks of age, demonstrating the long-term safety of maternal TDF therapy for preventing hepatitis B transmission.
Review
Biochemistry & Molecular Biology
Manon D. Owen, Bernadette C. Baker, Eleanor M. Scott, Karen Forbes
Summary: Metformin exposure during pregnancy can lead to increased risk of small for gestational age births and childhood obesity in offspring, potentially through effects on maternal vitamin B12 deficiency and folate imbalance. Further research is needed to elucidate the mechanisms by which metformin impacts fetal growth and long-term health outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Tesfaye S. Mengistu, Veronika Schreiber, Christopher Flatley, Jane Fox, Sailesh Kumar
Summary: The study investigated maternal and intrapartum risk factors for early severe neonatal morbidity in late preterm and early term infants. Results identified risk factors such as pre-existing diabetes, instrumental birth, and emergency cesarean for late preterm infants, while pre-existing and gestational diabetes, antepartum hemorrhage, and certain birth methods were significant for early term infants. Overall, the predicted probability of early severe neonatal morbidity decreased with increasing gestational age.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nikolaos Vrachnis, Savvas Argyridis, Dionysios Vrachnis, Nikolaos Antonakopoulos, Georgios Valsamakis, Christos Iavazzo, Dimitrios Zygouris, Nikolaos Salakos, Alexandros Rodolakis, Nikolaos Vlahos, George Mastorakos, Peter Drakakis, Zoi Iliodromiti
Summary: The study found that both FGF21 and insulin concentrations increased in cases of abnormal fetal growth. Higher levels of these hormones were observed in fetuses with restricted growth (SGA) or macrosomia (LGA).
Article
Toxicology
Ting Zhao, Yuchao Guo, Hongchen Ji, Guanghua Mao, Weiwei Feng, Yao Chen, Xiangyang Wu, Liuqing Yang
Summary: This study investigates the metabolic toxicity and mechanisms of acrylamide (ACR) in diabetic mice and finds that ACR can exacerbate glucose and lipid metabolic disorders in diabetic mice. Additionally, ACR exposure leads to oxidative stress and inflammatory damage. This research is important for understanding the effects and underlying mechanisms of ACR-induced metabolic toxicity in adults with diabetes.
TOXICOLOGY LETTERS
(2022)
Review
Nutrition & Dietetics
Melissa Thoene, Ann Anderson-Berry
Summary: This article discusses the preferred method of nutrient provision for preterm infants and the benefits of early enteral feeding in enhancing nutrient delivery and promoting development. It also suggests methods to improve clinical enteral delivery and highlights the impact of early enteral feeding on preterm infant health, including enhancing micronutrient delivery, promoting intestinal and brain development, and reducing inflammation.
Article
Medicine, General & Internal
Rafael Ceschin, Alexandria Zahner, William Reynolds, Nancy Beluk, Ashok Panigrahy
Summary: Aberrant cerebellar development is postulated in infants with congenital heart disease (CHD), leading to neurocognitive deficits. This study compared term-born CHD neonates and preterm-born neonates to investigate the effect of postnatal growth on cerebellar development. The CHD cohort showed significantly lower cerebellar volumes compared to the control and preterm groups. Changes in birth weight were correlated with cerebellar volume in preterm neonates but not in CHD neonates, suggesting differential mechanisms of aberrant cerebellar development.
Article
Pediatrics
Timur Azhibekov, Razaq Durodoye, Anna K. K. Miller, Claire L. L. Simpson, Robert L. L. Davis, Scott M. M. Williams, Leslie A. A. Bruggeman
Summary: In women of African ancestry, polymorphisms in the APOL1 gene are linked to the risk of preeclampsia. High-risk APOL1 genotypes in full-term infants are associated with an increased likelihood of being small for gestational age. In preterm pregnancies, fetal APOL1 genotype is associated with preeclampsia.
Article
Multidisciplinary Sciences
Luisa Ernsten, Lisa M. Koerner, Martin Heil, Gareth Richards, Nora K. Schaal
Summary: Hands and digits show sexual dimorphism, potentially reflecting prenatal androgen exposure. Male infants displayed longer digits and wider hands than female infants, with smaller digit ratios, indicating other factors may contribute to sexual dimorphism.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Maria Sonsoles Galan Arevalo, Ignacio Mahillo-Fernandez, Miguel Saenz De Pipaon, Luis Mariano Esteban, Diego Hernandez Martin, Juan Rodriguez Delgado, Jose Carlos Estevez Munoz, Mercedes Andeyro-Garcia, Roi Pineiro Perez, Ricardo Saviron-Cornudella
Summary: Newborns with fetal growth deceleration (FGD) but appropriate-for-gestational-age (AGA) weight experience catch-up growth, especially in weight and BMI, in the first year of life.
PEDIATRIC RESEARCH
(2023)
Article
Chemistry, Medicinal
Grigoris Zoidis, Eftichia Kritsi, Paulina Lecinska, Marija Ivanov, Panagiotis Zoumpoulakis, Marina Sokovic, Marco Catto
Summary: The study highlights the significant antifungal activity of novel 1,2,4-triazole derivatives against various strains of fungi compared to commercial fungicides. The research suggests that 1,2,4-triazole derivatives substituted with aromatic rings hold promise for antifungal drug discovery and development, with some compounds showing higher activity than established drugs like ketoconazole and itraconazole. Development of quantitative structure-activity relationship models aids in explaining the potency characteristics of these analogues.
Article
Chemistry, Analytical
Spyros J. Konteles, Irini F. Strati, Maria Giannakourou, Anthimia Batrinou, Spyros Papadakis, Dimitrios Ourailoglou, Panagiotis Zoumpoulakis, Vassilia J. Sinanoglou
Summary: The study aimed to prepare a functional instant herbal powder (IHP) from dehydrated herbal cold infused blends, easily dissolved in cold water, providing enhanced health benefits to consumers. IHP showed high antioxidant activity, good color and microbiological stability, and the potential to contribute to oral hygiene.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Applied
Georgios Koutrotsios, Dimitra Tagkouli, Georgios Bekiaris, Andriana Kaliora, Thalia Tsiaka, Konstantinos Tsiantas, Iordanis Chatzipavlidis, Panagiotis Zoumpoulakis, Nick Kalogeropoulos, Georgios Zervakis
Summary: The study showed that using grape marc plus wheat straw as substrate for mushroom cultivation can increase mushroom biological efficiency and shorten production cycles, resulting in higher levels of antioxidants, triterpenic acids, free amino acids, lovastatin, and ergosterol in the fruit bodies. Additionally, glucans, resveratrol, and fatty acids content did not vary significantly among mushrooms from the three substrates examined, while ergothioneine was significantly higher in fruit bodies grown on wheat straw.
Article
Pediatrics
Eftychia Ioanna Dimitrakopoulou, Abraham Pouliakis, Vasiliki Falaina, Theodoros Xanthos, Panagiotis Zoumpoulakis, Thalia Tsiaka, Rozeta Sokou, Zoi Iliodromiti, Theodora Boutsikou, Nicoletta Iacovidou
Summary: The composition and metabolic activity of gut microbiota in infants are influenced by the type of feeding, with differences observed between breastfed and formula-fed infants. The inclusion of probiotics and prebiotics in formula milk can impact the microbiome composition and fecal pH. Understanding these effects is important for developing optimal feeding strategies that support intestinal functionality, immune system, and metabolism in infants.
Article
Biochemistry & Molecular Biology
Charalambos Fotakis, Giorgos Moros, Anna Kontogeorgou, Nicoletta Iacovidou, Theodora Boutsikou, Panagiotis Zoumpoulakis
Summary: Hypothyroidism during pregnancy and lactation affects the composition of metabolites, leading to impaired lipid and glucose metabolic pathways as well as abnormal prenatal neurodevelopment. Monitoring is necessary for both untreated and hypothyroid women under replacement therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Konstantinos Tsiantas, Spyridon J. Konteles, Eftichia Kritsi, Vassilia J. Sinanoglou, Thalia Tsiaka, Panagiotis Zoumpoulakis
Summary: Advances in sequencing technologies have highlighted the importance of the gut microbiome to host health. Nutrition, particularly lipids, can influence gut microbiota composition and metabolic health. Holistic analytical approaches, such as lipidomics and metabolomics, are being used to study the interplay between gut microbiota and nutrition. This review summarizes the interactions between dietary and endogenous lipids and gut microbiota, and discusses the role of lipidomics in clinical interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dimitra Tagkouli, Thalia Tsiaka, Eftichia Kritsi, Marina Sokovic, Vassilia J. Sinanoglou, Dimitra Z. Lantzouraki, Panagiotis Zoumpoulakis
Summary: Wine lees, a byproduct of winemaking, contains valuable bioactive compounds. By optimizing microwave-assisted extraction, the bioactivity of wine lees extracts can be enhanced, particularly in terms of (poly)phenolic yield. Red varieties exhibit higher biological activity, and geographical origin and fermentation stage also influence the activity of the extracts.
Article
Chemistry, Medicinal
Eftichia Kritsi, Panagiota G. Liggri, Evgenia C. Stamati, Katerina E. Tsitsanou, Spyros E. Zographos, Antonios Michaelakis, Dimitrios Papachristos, Panagiotis Zoumpoulakis
Summary: This study aims to discover novel hit compounds for insect repellents by targeting the Odorant Binding Protein 1 (OBP1) using a computational methodology. In vitro and in vivo evaluations showed that coniferyl alcohol and 1,2-diphenyl-2-propanol exhibited high binding affinity to OBP1 and effective repellent activity against Aedes albopictus. These compounds have the potential to serve as scaffolds for the development of novel repellents.
Article
Biochemistry & Molecular Biology
Vasiliki Falaina, Charalambos Fotakis, Theodora Boutsikou, Thalia Tsiaka, Georgios Moros, Sotirios Ouzounis, Vasiliki Andreou, Zoi Iliodromiti, Theodoros Xanthos, Yvan Vandenplas, Nicoletta Iacovidou, Panagiotis Zoumpoulakis
Summary: This study compared the urine metabolic fingerprint of breastfed and synbiotic formula-fed neonates. No distinct differences were observed in the first two time points, but discrimination trends were observed after the 2nd month.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Thalia Tsiaka, Eftichia Kritsi, Dimitra Z. Lantzouraki, Paris Christodoulou, Diamantina Tsigrimani, Irini E. Strati, Vassilia J. Sinanoglou, Panagiotis Zoumpoulakis
Summary: There is an increasing interest in traditional herbal nutraceuticals in the current market, leading herbal formulations to become sought-after products with nutraceutical and disease-preventing properties. This study aimed to evaluate the potential nutraceutical effectiveness of ten herbal preparations using in silico techniques and LC-MS/MS analysis. The selected phenolic compounds were investigated for their binding potential using molecular target prediction tools, and aldose reductase emerged as the most promising molecular target. The results showed that certain compounds had high binding affinity, and the phytochemical profile analysis revealed that one specific herbal infusion exhibited significant inhibitory activity against aldose reductase.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Andromachi Tzani, Eftichia Kritsi, Lamprini Tsamantioti, Ioanna Kostopoulou, Maria-Anna Karadendrou, Panagiotis Zoumpoulakis, Anastasia Detsi
Summary: Flavanones and their biochemical precursors, chalcones, are naturally occurring compounds that are used in drug discovery for their diverse range of biological activities. In this study, novel flavanones and chalcones were synthesized and their antioxidant activity and DNA-binding ability were evaluated. The results showed that arylidene flavanone 5 exhibited the highest antioxidant activity, while chalcone 6 had the strongest interaction with DNA.
Article
Biochemistry & Molecular Biology
Thalia Tsiaka, Eftichia Kritsi, Sotirios M. M. Bratakos, Georgios Sotiroudis, Panagiota Petridi, Ioanna Savva, Paris Christodoulou, Irini F. F. Strati, Panagiotis Zoumpoulakis, Dionisis Cavouras, Vassilia J. J. Sinanoglou
Summary: This study investigated the physicochemical attributes, antioxidant properties, phytochemical profile, and potential biological activities of Greek or Turkish coffee. The research revealed that roasting degree is the most critical factor affecting these parameters. Light-roasted coffees showed higher color parameters and total phenolic content, while decaffeinated coffees contained more phenolic compounds. Chlorogenic and coumaric acids in the coffee showed promising activity against human acetylcholinesterase and alpha-glucosidase enzymes. This study provides a comprehensive understanding of the properties and bioactivity of this type of coffee preparation.
Article
Biochemistry & Molecular Biology
Charikleia Kyrkou, Charalambos Fotakis, Aristea Dimitropoulou, Foteini Tsakoumaki, Panagiotis Zoumpoulakis, Georgios Menexes, Costas G. Biliaderis, Apostolos P. Athanasiadis, Alexandra-Maria Michaelidou
Summary: This study examined the association between dietary protein patterns (DPPs) and neonatal anthropometrics in well-nourished pregnant women. The results showed that DPPs varied in protein and fiber intakes, with different effects on birth height and ponderal index of infants. Metabolomics analysis revealed distinct metabolic signatures associated with DPPs, highlighting the importance of maternal diet in neonatal outcomes.
