Discovery of cytochrome bc1 complex inhibitors inspired by the natural product karrikinolide

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Functional redundancy in the control of seedling growth by the karrikin signaling pathway

(2016) John P. Stanga et al.   PLANTA

Smoke-water, karrikinolide and gibberellic acid stimulate growth in bean and maize seedlings by efficient starch mobilization and suppression of oxidative stress

(2016) T.O. Sunmonu et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Synthesis of (+)-crocacin D and simplified bioactive analogues

(2015) Adele E. Pasqua et al.   BIOORGANIC & MEDICINAL CHEMISTRY

What are karrikins and how were they ‘discovered’ by plants?

(2015) Gavin R. Flematti et al.   BMC BIOLOGY

Discovery of N-benzoxazol-5-yl-pyrazole-4-carboxamides as nanomolar SQR inhibitors

(2015) Li Xiong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Quorum Sensing Inhibitors - Small Molecules, Big Messages

(2015) Antonia Delago et al.   ISRAEL JOURNAL OF CHEMISTRY

Ametoctradin is a Potent Qo Site Inhibitor of the Mitochondrial Respiration Complex III

(2015) Xiaolei Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III

(2015) Hua Cheng et al.   NEW JOURNAL OF CHEMISTRY

Binding of the respiratory chain inhibitor ametoctradin to the mitochondrialbc1complex

(2015) Marcus Fehr et al.   PEST MANAGEMENT SCIENCE

Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1

(2015) Michael J. Capper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain

(2014) Haruhiko Fuwa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Computational and Experimental Insight into the Molecular Mechanism of Carboxamide Inhibitors of Succinate-Ubquinone Oxidoreductase

(2014) Xiao-Lei Zhu et al.   ChemMedChem

Karrikins from plant smoke modulate bacterial quorum sensing

(2013) Aviad Mandabi et al.   CHEMICAL COMMUNICATIONS

HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochromebc1Complex

(2012) Cindy Vallières et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rieske Iron-Sulfur Protein of the Cytochrome bc1 Complex: A Potential Target for Fungicide Discovery

(2012) Wen-Chao Yang et al.   CHEMBIOCHEM

Design, Synthesis, and Bioevaluation of Novel Strobilurin Derivatives

(2012) Xiaolei Zhu et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis and Antifungal Activity of Novel Sclerotiorin Analogues

(2012) Long Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Computational Discovery of Picomolar Qo Site Inhibitors of Cytochrome bc1 Complex

(2012) Ge-Fei Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc1 complex inhibitors

(2011) Fu Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent developments in the total synthesis of fungicidal natural products—a crop protection perspective

(2011) Carl F. Nising et al.   CHEMICAL COMMUNICATIONS

Plant-derived smoke: Old technology with possibilities for economic applications in agriculture and horticulture

(2011) M.G. Kulkarni et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Structure−Activity Relationship of Karrikin Germination Stimulants

(2010) Gavin R. Flematti et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Total synthesis of neopeltolide and analogs

(2010) Yubo Cui et al.   TETRAHEDRON

Efficient synthesis of karrikinolide via Cu(II)-catalyzed lactonization

(2010) Kazumasa Matsuo et al.   TETRAHEDRON

Natural Product Inspired Diversity Oriented Synthesis of Tetrahydroquinoline Scaffolds as Antitubercular Agent

(2010) Atul Kumar et al.   ACS Combinatorial Science

Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex

(2009) Edward A. Berry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Novel Mycotoxin fromAcremonium exuviarumIs a Powerful Inhibitor of the Mitochondrial Respiratory Chain Complex III

(2009) Alexey G. Kruglov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Alkyl Substituted 2H-Furo[2,3-c]pyran-2-ones as Germination Stimulants Present in Smoke

(2009) Gavin R. Flematti et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Subnanomolar Inhibitor of Cytochromebc1Complex Designed by Optimizing Interaction with Conformationally Flexible Residues

(2009) Pei-Liang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Karrikins: A new family of plant growth regulators in smoke

(2009) Sheila D.S. Chiwocha et al.   PLANT SCIENCE

The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D

(2008) Patrick J. Crowley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Total Synthesis and Biological Activity of Neopeltolide and Analogues

(2008) Viktor V. Vintonyak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

(2008) Christopher Cordier et al.   NATURAL PRODUCT REPORTS

Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide

(2008) Olesya A Ulanovskaya et al.   Nature Chemical Biology

Karrikins Discovered in Smoke Trigger Arabidopsis Seed Germination by a Mechanism Requiring Gibberellic Acid Synthesis and Light

(2008) D. C. Nelson et al.   PLANT PHYSIOLOGY

Smoke-derived butenolide: Towards understanding its biological effects

(2008) M.E. Light et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Synthesis of the seed germination stimulant 3-methyl-2H-furo[2,3-c]pyran-2-ones utilizing direct and regioselective Ti-crossed aldol addition

(2008) Ryohei Nagase et al.   TETRAHEDRON LETTERS

Synthesis of butenolides as seed germination stimulants

(2008) Kingmo Sun et al.   TETRAHEDRON LETTERS

Total Synthesis and Structural Revision of the Marine Macrolide Neopeltolide

(2007) Daniel W. Custar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY