Article
Biochemistry & Molecular Biology
Xing-Rong Peng, Qian Wang, Hui-Rong Wang, Kun Hu, Wen-Yong Xiong, Ming-Hua Qiu
Summary: Novel meroterpenoid dimers, (+/-)-applandimeric acids A-D, were isolated from Ganoderma applanatum. Compound 4 showed potential for inhibiting inflammation by binding to FPR2 and inhibiting lipid accumulation by activating the AMPK pathway in adipocytes. This compound could be a lead compound for treating obesity and related diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fu-Ying Qin, Yan-Yi Chen, Jiao-Jiao Zhang, Yong-Xian Cheng
Summary: In this study, ten pairs of novel meroterpenoid dimers and one known compound were isolated from Ganoderma mushrooms. The structural elucidation of the new compounds and their absolute configurations depended on spectroscopic analysis and electronic circular dichroism calculations. Biological studies revealed that several of these compounds exhibited cytotoxicity against triple negative breast cancer cells and inhibited cell mobility. These findings provide new insights into the biological role of Ganoderma meroterpenoids in triple negative breast cancer.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ying Chen, Yanchun He, Xiaoyan Pang, Xuefeng Zhou, Yonghong Liu, Bin Yang
Summary: Four previously uncharacterized compounds and twelve known compounds were isolated from the coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf. The compounds were analyzed for their structures and enzyme inhibitory activities, and two compounds showed notable inhibitory effects on neuraminidase.
Article
Plant Sciences
Ashraf M. Omar, Sijia Sun, Min Jo Kim, Nguyen Duy Phan, Ahmed M. Tawila, Suresh Awale
Summary: The antiausterity strategy shows promise in discovering lead compounds with unprecedented anticancer activities by targeting cancer cells' tolerance to nutrition starvation. The study isolated multiple compounds, including six new benzophenones, from an ethanol extract of Betula alnoides, which displayed antiausterity activity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions. These new compounds showed potential anticancer effects and induced alterations in cancer cell morphology under nutrient-deprived conditions.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Geum Jin Kim, Songhee Park, Eonmi Kim, Hyukbean Kwon, Hae-Jin Park, Joo-Won Nam, Seong-Soo Roh, Hyukjae Choi
Summary: The study found that extracts of Spartina anglica have antioxidant, anti-obesity, and whitening properties. Particularly, the ethyl acetate fraction derived from the aerial parts showed strong radical-scavenging and pancreatic lipase inhibitory activities.
Article
Multidisciplinary Sciences
Aisha Umar, Shakil Ahmed
Summary: This study aimed to investigate the efficient laccase production of Ganoderma leucocontextum, a fungus that was identified by ITS regions of DNA and phylogenetic tree analysis. The optimal growth and nutritional conditions were optimized to enhance the laccase production. The purified laccase exhibited high thermal stability and optimal activity under specific pH and temperature conditions.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jiao-Cen Guo, Li Yang, Qing-Yun Ma, Ya-Zhe Ge, Fan-Dong Kong, Li-Man Zhou, Fei Zhang, Qing-Yi Xie, Zhi-Fang Yu, Hao-Fu Dai, You-Xing Zhao
Summary: This study isolated ten new compounds from the fruiting bodies of Ganoderma australe, including seven undescribed lostane-type triterpenoids and one polyhydroxylated sterol. These new compounds showed significant a-glucosidase inhibitory activities and one exhibited weak cytotoxicity against cancer cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Qi-Fang He, Zhen-Long Wu, Xiao-Jun Huang, Tian-Qi Xia, Genyun Tang, Wei Tang, Lei Shi, Wen-Cai Ye, Ying Wang
Summary: This study identified four novel stilbene dimers and their biosynthetically related stilbene monomers from Cajanus cajan leaves. The compounds exhibited unique structural features and significant protein tyrosine phosphatase-1B (PTP1B) inhibition effects. Preliminary investigation on the most potent compound's mode of action was conducted through molecular docking and binding free energy calculation.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Qingxia Xu, Qian Lv, Lu Liu, Yingtao Zhang, Xiuwei Yang
Summary: This study isolated various novel bakuchiol derivatives from Psoralea corylifolia L., some of which showed anti-inflammatory activities. Structure-activity relationship analysis suggested that uncyclized compounds with oxygen substitution at specific sites exhibit strong inhibitory effects.
Article
Nutrition & Dietetics
Zongqi Zhang, Sicong Chen, Xunfan Wei, Jinhua Xiao, Dawei Huang
Summary: This study demonstrates that the extract of Polyrhachis vicina, an edible insect, possesses excellent antioxidant and pancreatic lipase inhibition activities. The major polyphenols in the extract interact with pancreatic lipase through various mechanisms. Therefore, Polyrhachis vicina extract can be used as a nutraceutical to alleviate oxidative stress-induced disease and manage obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Bo Peng, Qingyun Peng, Jianglian She, Bin Yang, Xuefeng Zhou
Summary: Ten secondary metabolites were isolated from a marine coral-derived fungus, and their cytotoxic, antibacterial, and enzyme inhibitory activities were evaluated. Monacolin K and its derivative showed significant pancreatic lipase inhibitory effects.
RECORDS OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Panida Chinthanom, Vanicha Vichai, Pranee Rachtawee, Thitiya Boonpratuang, Masahiko Isaka
Summary: Investigation of cultivated fruiting bodies of Ganoderma weberianum led to the discovery of 11 previously unreported lanostane dimers and several new derivatives. Ganoweberianone D (4a) and isoganoweberianone D (4b) exhibited significant antimalarial activity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Xinyi Wang, Xin Ai, Zehui Zhu, Mingxin Zhang, Fei Pan, Zichen Yang, Ou Wang, Liang Zhao, Lei Zhao
Summary: Peptides derived from sesame could potentially inhibit the activity of pancreatic lipase, reducing triglyceride absorption and preventing obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ravindra Patil, Samadhan Patil, Vijay Maheshwari, Mohini Patil
Summary: The study demonstrates the inhibitory effect of pentacyclic triterpenoids (PIT) on pancreatic lipase (PL), indicating their potential as a natural PL inhibitor in the treatment of obesity. The isolated PTT was identified as lupeol, and the endophytic isolate was identified as Colletotrichum gigasporum, showing promise as a valuable bioresource for obesity treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Entomology
Joaquin Navarro del Hierro, Emma Cantero-Bahillo, Tiziana Fornari, Diana Martin
Summary: The food industry is investing more resources in the production of nutritious and sustainable products from edible insects, with natural extracts having added value for human health. Bioactive extracts from edible insects have been scarcely explored, but they show potential as antioxidants and inhibitors of pancreatic lipase. Extraction conditions can affect the bioactivity of insect extracts, with factors like defatting and solvent choice playing a role.
Article
Biotechnology & Applied Microbiology
He-Ping Chen, Ikuro Abe
Summary: Prenyltransferase (PTase) enzymes are crucial in natural product biosynthesis by transferring isoprene units to target substrates, resulting in prenylated compounds with enhanced bioactivity. There has been an increasing focus on microbial PTase enzymes in the past two decades for synthetic biology applications, leading to the synthesis of novel prenylated compounds.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui Tao, Takahiro Mori, Heping Chen, Shuang Lyu, Akihito Nonoyama, Shoukou Lee, Ikuro Abe
Summary: This study reports the biochemical and structural characteristics of the Fe/α-KG oxygenase SptF and its remarkable catalytic versatility. SptF catalyzes various continuous oxidation reactions and exhibits broad substrate specificity. These findings demonstrate the potential of SptF as a promising biocatalyst for oxidation reactions.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Xin Sun, Min Zhou, Jing-Ping Zhu, Xiang-Fei Zhang, Zu-Jiang Liu, Hao-Ran Li, Yan Chen, He-Ping Chen, Jie Zhao, Jian-Xin Pu, Miao Yu, Ji-Kai Liu, Bin Wu
Summary: A photoinduced intramolecular cyclization of allyl acrylates to synthesize fully substituted spiro-gamma-butyrolactone compounds is described. The reaction is believed to proceed through activation of the carbonyl group upon ultraviolet irradiation, 1,4-hydrogen atom transfer, and intramolecular cyclization of diradical species, an intramolecular hydrogen abstraction strategy, based on a series of control and isotope studies as well as DFT calculations.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Shui-Lin Liu, Lin Zhou, He-Ping Chen, Ji-Kai Liu
Summary: Epigenetic modifiers have been found to regulate the gene expression of fungal biosynthetic pathways. In this study, a chemical investigation on histone deacetylase inhibitor (HDI)-modified cultures of Cyathus stercoreus led to the discovery of nine previously undescribed sesquiterpenes. These sesquiterpenes were found to be exclusive or overproduced in the epigenetic modified cultures. Additionally, a previously unreported sesquiterpene skeleton was identified. Some of the compounds showed weak inhibitory activity against Escherichia coli.
Article
Microbiology
Lin Zhou, Li-Li Guo, Masahiko Isaka, Zheng-Hui Li, He-Ping Chen
Summary: Nanjing Shangri-La Hotel is under investigation for alleged unauthorized renovation, and the hotel management has stated that they will cooperate with the authorities and make necessary corrections in accordance with regulations.
Article
Biochemistry & Molecular Biology
Zhen-Zhu Zhao, Xuan Zhao, Ying-Ying Si, Zhen-Zhen Wang, Yan-Jun Sun, He-Ping Chen, Wei-Sheng Feng, Ji-Kai Liu
Summary: Eighteen linear triquinane sesquiterpenoids, including seventeen previously undescribed ones, were isolated from the fungus Stereum hirsutum. The structures and absolute configurations of the isolates were determined through extensive spectroscopic analysis and X-ray crystallography. The study also summarized an empirical rule about the orientations of substitutions at specific positions. Among the compounds, hirsutuminoid B showed anti-inflammatory and cytotoxic activity.
Article
Chemistry, Medicinal
Lin Zhou, Subiy Akbar, Meng-Xi Wang, He-Ping Chen, Ji-Kai Liu
Summary: Ten new nor-lanostane triterpenes were identified from the medicinal fungus Ganoderma australe through chemical investigation. The chemical structures and absolute configurations were determined, and the biosynthesis pathways of these compounds were proposed. Two of the compounds showed moderate inhibition against nitric oxide production in macrophage cells.
NATURAL PRODUCTS AND BIOPROSPECTING
(2022)
Article
Plant Sciences
Panida Chinthanom, Wilunda Choowong, Tuksaporn Thummarukcharoen, He-Ping Chen, Ji-Kai Liu, Masahiko Isaka
Summary: Eight undescribed lanostane triterpenoids (1-8) were isolated from cultures of Ganoderma weberianum TBRC-BCC 60642. Lanostane constituents showed different structural types between mycelial cultures and fruiting bodies. Lanostanes 2, 3, and 6 exhibited moderate antimalarial activity against Plasmodium falciparum K1.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Xinyang Li, He-Ping Chen, Lin Zhou, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru, Ikuro Abe, Ji-Kai Liu
Summary: Cordycicadins A-D are four novel polyketides isolated from the liquid fermentation of Cordyceps cicadae JXCH1. Their structures were determined using spectroscopic analysis, single-crystal X-ray diffraction, and computational methods. Cordycicadins A and B showed antifeedant activity against silkworm larvae.
Article
Chemistry, Medicinal
Lin Zhou, He-Ping Chen, Xinyang Li, Ji-Kai Liu
Summary: Two triterpenes with unique 6/6/6/5/6 scaffolds, ganoaustralins A and B, were isolated from the fruiting bodies of Ganoderma australe. Their structures, absolute configurations, and biosynthetic pathways were determined, with ganoaustralin B showing weak inhibition against beta-secretase 1.
Article
Biochemistry & Molecular Biology
Qian-Qian Meng, Shun-Yao Tong, Xing-Rong Peng, Yu-Qing Zhao, Zheng-Hui Li, He-Ping Chen, Ji-Kai Liu
Summary: In this study, nine new pregnane glycosides were isolated from the ethnobotanical plant Marsdenia tenacissima, commonly used by the Dai people in Yunnan Province, China. The structures were analyzed using spectroscopic techniques and the absolute configurations of the sugar moieties were determined. Some of the isolated compounds showed inhibitory activity against nitric oxide production in activated macrophage cells.
Article
Plant Sciences
Ming-Xuan Gao, Feng Wu, Si-Qiong Teng, He-Ping Chen, Zheng-Hui Li, Juan He, Tao Feng, Ji-Kai Liu
Summary: In our study, we isolated twelve previously undescribed triquinane sesquiterpene glycosides, antrodizonatins A-L (1-12), and four known compounds (13-16) from the fermentation of the basidiomycete Antrodiella zonata. The structures of these compounds were determined through extensive spectroscopic analysis and theoretical calculations. Furthermore, compounds 1, 5, and 12 exhibited antibacterial activity against Staphylococcus aureus with MIC50 values of 35, 34, and 69 μM, respectively.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Jing Fan, Pai Liu, Kuan Zhao, He-Ping Chen
Summary: Three previously undescribed compounds were isolated from the cultures of Cordyceps cicadae JXCH1. Their structures and relative configurations were determined by NMR spectroscopic analysis and crystal structure determination. One of the compounds exhibited an unusual structural feature and showed inhibitory effects on human lung cancer cells and murine macrophages.
NATURAL PRODUCTS AND BIOPROSPECTING
(2023)
Article
Chemistry, Multidisciplinary
Takahiro Mori, Yu Nakashima, Heping Chen, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe
Summary: Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed to expand its function from an isomerization reaction to catalyzing a spiro-ring formation reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhen-Zhu Zhao, Qi-Lu Zhao, Wei-Sheng Feng, Hai-Rong He, Meng Li, Gui-Min Xue, He-Ping Chen, Ji-Kai Liu
Summary: Seven new sesquiterpenoids, along with four known compounds, were isolated from cultures of the wood-decaying fungus Steccherinum ochraceum HFG119. Structural characterization and biological evaluation of these compounds suggest potential bioactivity.
