Article
Chemistry, Multidisciplinary
Yukiya Takayama, Kosuke Kusamori, Chihiro Tsukimori, Yosuke Shimizu, Mika Hayashi, Ikumi Kiyama, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa
Summary: In this study, MSCs were modified with DOX-Lips to efficiently deliver doxorubicin to tumor cells, demonstrating significant tumor growth inhibition in murine models. The results suggest that DOX-Lip-modified MSCs could serve as an effective carrier system for targeted tumor therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Cell & Tissue Engineering
Yao Sun, Guoliang Liu, Kai Zhang, Qian Cao, Tongjun Liu, Jiannan Li
Summary: Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. Researchers have increasingly focused on using exosomes for drug delivery, especially MSC-EXOs, due to their immune properties, tumor-homing properties, and elastic properties. This review article summarizes the characteristics of MSC-EXOs and introduces production, purification, and drug loading methods to address existing problems and provide suggestions for future studies.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Materials Science, Biomaterials
Mian Wang, Yuanfeng Xin, Hao Cao, Wanlu Li, Yifei Hua, Thomas J. Webster, Chao Zhang, Wenjie Tang, Zhongmin Liu
Summary: MSC membrane-coated nanoparticles are an effective method for selective targeting and enhancing therapeutic efficacy. Combining bioengineered cell membranes with synthesized nanoparticles offers a wide range of possibilities for the development of targeted drug delivery.
BIOMATERIALS SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Jafar Rezaie, Vahid Nejati, Monireh Mahmoodi, Mahdi Ahmadi
Summary: Extracellular vesicles (EVs), particularly MSCs-EVs, have shown great potential as a drug delivery system in nanomedicine. They can selectively deliver therapeutic agents to target cells and improve various diseases. However, there are still challenges that need to be addressed for the clinical translation of modified MSCs-EVs.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mahdi Ahmadi, Monireh Mahmoodi, Maryam Shoaran, Fereshteh Nazari-Khanamiri, Jafar Rezaie
Summary: New therapeutic approaches are urgently needed for combating metastatic cancers, which cause over 8 million deaths per year worldwide. Mesenchymal stem cells (MSCs) have shown potential as a novel treatment option for cancer, with their exosomes playing a crucial role in regulating tumor progression. However, there is still controversy surrounding the exact association between MSC-derived exosomes and tumors. Nevertheless, the use of MSC-derived exosomes as drug delivery systems and standalone therapeutics is actively being explored, and engineering these exosomes to target tumor cells shows promise in improving the efficacy of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Runrun Li, Thea A. Vedelaar, Alina Sigaeva, Yue Zhang, Kaiqi Wu, Hui Wang, Xixi Wu, Peter Olinga, Malgorzata K. Wlodarzyk-Biegun, Romana Schirhagl
Summary: Polymer nanoparticles are widely used in drug delivery and cause potential concerns regarding the increase in nano- or microplastics in the environment. To understand their mechanism of action and ensure safe usage, it is important to know their localization within cells and tissues. We labeled polymer nanoparticles with nanodiamond particles, allowing long-term imaging and tracking, and demonstrated this principle in both cells and liver tissues.
ANALYTICAL CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Tingting Hu, Zhou Qin, Chao Shen, Han-Lin Gong, Zhi-Yao He
Summary: Mitochondria play crucial roles in cancer cells, and precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Overcoming the challenge of mitochondrial negative potential preventing molecules from reaching them, advancements in nanosystems such as liposomes, nanoparticles, and nanomicelles provide hope for targeted drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Valentina Cocce, Mara Bonelli, Silvia La Monica, Roberta Alfieri, Luisa Doneda, Eleonora Martegani, Giulio Alessandri, Costanza Annamaria Lagrasta, Aldo Gianni, Valeria Sordi, Francesco Petrella, Leda Roncoroni, Francesca Paino, Augusto Pessina
Summary: Malignant pleural mesothelioma, an asbestos-related tumor, has poor response to chemotherapy. Adult mesenchymal stromal cells derived from bone marrow or adipose tissue can be a good model for cell-based therapy, and using Paclitaxel-loaded mesenchymal stromal cells inhibits mesothelioma cell proliferation more effectively than Paclitaxel alone. In vivo studies using a minimal amount of 106 mesenchymal stromal cells loaded with Paclitaxel showed the same efficacy as systemic administration of Paclitaxel, supporting the use of mesenchymal stromal cells as a drug delivery system for solid tumors.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Lianlian Fan, Anhui Wei, Zihui Gao, Xupeng Mu
Summary: Nanodrug delivery systems face challenges of weak drug targeting, immune system clearance, and low biocompatibility. Cell membrane, especially Mesenchymal stem cell (MSC) membrane, can be used as a drug coating material to overcome these limitations. MSC membrane-coated nanoparticles have potential applications in tumor treatment, inflammatory disease, tissue regeneration, and other fields. This review summarizes recent progress in the use of MSC membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for future design and clinical application of membrane carriers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Kyeong Jin Cho, Young-Eun Cho, Jihoon Kim
Summary: The lymphatic system is a crucial target in controlling cancer progression and adaptive immune response. Nano-sized materials have shown advantages in delivering drugs to lymph nodes and overcoming barriers associated with lymphatic physiology. Sustained drug delivery systems have the potential to improve the therapeutic index of immune modulating agents.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biotechnology & Applied Microbiology
L. S. Litvinova, V. V. Shupletsova, O. G. Khaziakhmatova, A. G. Daminova, V. L. Kudryavtseva, K. A. Yurova, V. V. Malashchenko, N. M. Todosenko, V. Popova, R. I. Litvinov, E. I. Korotkova, G. B. Sukhorukov, A. J. Gow, D. Weissman, E. N. Atochina-Vasserman, I. A. Khlusov
Summary: Studies have shown that human mesenchymal stem cells (MSCs) can effectively load synthetic microcapsules without damaging the structural integrity of the cells, allowing for the secretion of unexpressed cytokines, retention of motility, and migration ability through pores. Thus, using human MSCs as a delivery vehicle for microcapsules to specific sites of inflammation may provide a new therapeutic perspective for conditions such as stroke, cancer, or inflammatory diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Tong Yin, Yan Liu, Wenbo Ji, Jianhua Zhuang, Xiaohan Chen, Baofeng Gong, Jianjian Chu, Wendanqi Liang, Jie Gao, You Yin
Summary: With the increasing population aging, the prevalence of Alzheimer's disease (AD) is also on the rise. However, there is currently no effective treatment available to slow down or stop the progression of AD. This review highlights the engineering strategies of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and discusses their potential as therapeutics for AD. The review also presents the challenges and prospects associated with the clinical applications of engineered MSC-EVs in AD therapy.
Review
Chemistry, Multidisciplinary
Lu Tang, Shun He, Yue Yin, Jing Li, Qiaqia Xiao, Ruotong Wang, Lijun Gao, Wei Wang
Summary: This article introduces neutrophils as a promising platform for cancer and inflammatory disease treatment and discusses the recent advancements in the application of nanomaterials in neutrophil-based therapies. It explores how nanomaterials improve treatment efficacy and overcome their limitations, and outlines emerging therapeutic strategies targeting neutrophils and novel approaches for COVID-19-related treatments.
Review
Medicine, Research & Experimental
Lu Tang, Jing Li, Ting Pan, Yue Yin, Yijun Mei, Qiaqia Xiao, Ruotong Wang, Ziwei Yan, Wei Wang
Summary: Despite advancements in medicine, cancer remains a leading cause of death worldwide. Traditional treatment strategies often come with severe adverse effects and limited efficacy. Nanotechnology, particularly carbon nanomaterials, has shown great promise in cancer therapy due to their unique properties. Developing carbon-based nanoplatforms is critical for improving cancer theranostics. This review introduces the use of graphene, graphdiyne, fullerene, carbon nanotubes, and carbon quantum dots in cancer treatment, as well as their diagnostic potential.
Article
Pharmacology & Pharmacy
Fangrong Zhang, Gesa Richter, Benjamin Bourgeois, Emil Spreitzer, Armin Moser, Andreas Keilbach, Petra Kotnik, Tobias Madl
Summary: This study presents a workflow for screening protein formulations using SAXS, demonstrating its advantages over DLS in measuring protein particle interactions and long-term stability.
Review
Oncology
Lu Tang, Aining Zhang, Ziyao Zhang, Qingqing Zhao, Jing Li, Yijun Mei, Yue Yin, Wei Wang
Summary: Combining immunotherapy and phototherapy is considered the ideal approach for treating tumors. Inorganic nanomaterials, with their unique physicochemical properties, play a crucial role in photoimmunotherapy (PIT) by serving as carriers for immunomodulatory agents and as photothermal agents or photosensitizers in phototherapy.
CANCER COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Yanqiang Huang, Rujia Li, Yuanyuan Dai, Chun Qin, Jikai He, Shixian Yang, Tengqi Wang, Yujie Su, Lizhou Jia, Wei Zhao
Summary: This study engineered a multifunctional nanodrug, RHL@BP, for the treatment of drug resistant H. pylori infection. The nanodrug efficiently delivered ISL, an active compound from traditional Chinese medicine, to enhance its antibacterial effect against drug resistant H. pylori under near-infrared irradiation. The controlled release of ISL triggered by the acid sensitivity of BP and photothermal instability of RHL exhibited significant synergistic antibacterial activity against drug resistant H. pylori. The study demonstrates a potential strategy for the clinical treatment of drug resistant H. pylori infections.
MATERIALS & DESIGN
(2022)
Review
Pharmacology & Pharmacy
Jin Gao, Yujie Su, Zhenjia Wang
Summary: This review provides an overview of the current research on bacterial membrane vesicles (BMVs), including their production, types, and therapeutic applications. The authors discuss various platforms of BMVs and how they can be engineered using chemical, physical, and genetic methods. The review also examines the methods of drug loading in BMVs and their limitations. Several therapeutic platforms of BMVs for improving the treatment of infectious diseases and cancers are reviewed. The authors emphasize the need for rigorous approaches and methods to develop reproducible and scalable drug delivery systems for translation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Engineering, Biomedical
Yujie Su, Wei Wang, Qiaqia Xiao, Lu Tang, Tingting Wang, Mengying Xie, Yangnan Su
Summary: Modern lifestyle has led to an increase in obesity, and current anti-obesity medications have limited efficacy and severe side effects. This study developed a drug delivery platform based on a macrophage cell membrane-coated recombinant high-density lipoprotein (rHDL) to selectively deliver therapeutic drugs to adipose tissue. By combining rosiglitazone and sildenafil, the study achieved a synergistic therapeutic outcome in regulating diet-induced obesity in a mice model. The treatment resulted in significant weight reduction and improved metabolic status. Moreover, the delivery system demonstrated a sustainable self-reinforcement effect, enhancing the accumulation of drugs in adipose tissue for subsequent administrations.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Yijun Mei, Lu Tang, Lidong Zhang, Jingyi Hu, Ziyao Zhang, Shun He, Jing Zang, Wei Wang
Summary: Combining immune checkpoint blockade therapy with other treatment modalities through nanotechnology can enhance immunity for effective cancer treatment. In this study, a three-in-one nanocomposite was fabricated, which could precisely target tumors and strengthen the antitumor efficacy through the interaction of different components. The combination therapy demonstrated a positive feedback-mediated multimodal antitumor effect and the potential for long-term tumor immune memory establishment.
Review
Materials Science, Biomaterials
Lu Tang, Cong Fu, Aining Zhang, Xiyue Li, Yuqi Cao, Jingwen Feng, Hening Liu, Haijuan Dong, Wei Wang
Summary: Cerebral ischemic stroke is a serious neurological disorder that leads to long-term disability or death worldwide. Nanobiotechnology offers new insights and alternatives for effective management of ischemic stroke by overcoming the limitations of conventional treatment methods. This review highlights the recent achievements in using diverse nanoplatforms for targeted delivery and therapeutic approaches against ischemic stroke, including neuroprotection, anti-inflammation, thrombolysis, blood-brain barrier penetration, and reactive oxygen species scavenging. The rational design of versatile nanoplatforms and the challenges, opportunities, and future perspectives in nanobiotechnology for ischemic stroke management are also discussed.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jin Gao, Yujie Su, Zhenjia Wang
Summary: Inflammation resolution is achieved through specialized pro-resolving mediators, such as RvD1 and RvD2, which have been shown to benefit the treatment of inflammation disorders. These mediators regulate interactions between endothelial cells and neutrophils in the lung, promoting resolution of lung inflammation.
Proceedings Paper
Automation & Control Systems
Zihan Zhang, Zhentao Hu, Junwei Li, Yujie Su
Summary: The study uses evidence theory to achieve spatial-temporal fusion of target recognition information. By introducing prospect value function and credibility decay model, spatial-temporal evidence is adjusted and combined, considering the dynamic and sequential characteristics. The numerical simulation results show that this method can handle conflict information and is more reasonable.
2022 7TH INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION ENGINEERING, ICRAE
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Jing Shu, Junming Wang, Yujie Su, Honghai Liu, Zheng Li, Raymond Kai-Yu Tong
Summary: This paper presents a posture perception method for soft actuators using long short-term memory (LSTM) neural networks and a novel flexible bending sensor. The method was validated on a finger-size one DOF pneumatic fiber-reinforced bending actuator and showed accurate posture sensing.
2022 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI'22) JOINTLY ORGANISED WITH THE IEEE-EMBS INTERNATIONAL CONFERENCE ON WEARABLE AND IMPLANTABLE BODY SENSOR NETWORKS (BSN'22)
(2022)
Proceedings Paper
Engineering, Biomedical
Yujie Su, Wuxiang Zhang, Xilung Ding
Summary: In this study, an observer based sliding mode control method is proposed to solve the problems in estimation and controlling caused by disturbance in a knee exoskeleton. A sliding mode disturbance observer is designed to estimate the disturbance, followed by impedance control for human-robot interaction control. The results demonstrate that the proposed method performs better in estimating and controlling in the presence of unknown disturbance.
NEW TRENDS IN MEDICAL AND SERVICE ROBOTICS
(2022)
Article
Materials Science, Biomaterials
Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
Summary: This study successfully developed a novel nanoplatform based on a lipid-polymer hybrid system for targeted cancer treatment by co-loading photothermal and chemotherapeutic drugs. The nanoplatform demonstrated good stability, imaging properties, and significant inhibitory effect on tumor growth.
BIOMATERIALS SCIENCE
(2022)
