Review
Polymer Science
Chao-Ping Fu, Xing-Yu Cai, Si-Lin Chen, Hong-Wei Yu, Ying Fang, Xiao-Chen Feng, Li-Ming Zhang, Chang-Yong Li
Summary: Hyaluronic acid (HA) is extensively used as a carrier for anticancer drugs due to its biocompatibility and ability to target cancer cells. This article comprehensively reviews the fabrication of HA-based nanocarriers for drug delivery, including prodrugs, organic carrier materials, and inorganic composite nanocarriers. The progress, design, and optimization of these nanocarriers and their impact on cancer therapy are discussed, as well as future perspectives in this field.
Article
Nanoscience & Nanotechnology
Junyan Chen, Wuyan Xu, Tianming Dai, Songsong Jiao, Xiang Xue, Jiayang Jiang, Siming Li, Qingqi Meng
Summary: In this study, HA-based cartilage-targeted nanomicelles were constructed to deliver pioglitazone in a sustained manner for the treatment of osteoarthritis (OA). The results showed that C-HA-DOs effectively inhibited cell death, restored cell function, and delayed the progression of OA by targeting cartilage.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Physical
Mengyi Li, Shuai Jiang, Adelina Haller, Sebastian Wirsching, Michael Fichter, Johanna Simon, Manfred Wagner, Volker Mailander, Stephan Gehring, Daniel Crespy, Katharina Landfester
Summary: This study developed a DXM-phosphate-based polyprodrug encapsulated in silica nanocontainers, showing enhanced control of inflammatory responses in liver cells, highlighting the advantage of combining the polyprodrug strategy with nanocarrier-mediated delivery for water-soluble low molecular weight drugs.
NANOSCALE HORIZONS
(2021)
Article
Materials Science, Biomaterials
Fusheng Zhang, Gongcui Pei, Baihao Huang, Jianchang Xu, Lijuan Zhang
Summary: This study investigated a micelle structure that can enhance drug release performance and revealed the underlying mechanisms. By utilizing crosslinking and esterase-responsive strategies, the release performance of the micelles can be improved, showing promising potential for enhancing both early and late drug release performance.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Abere Habtamu Manayia, Fasih Bintang Ilhami, Ai-Wei Lee, Chih-Chia Cheng
Summary: The study successfully obtained a high yield difunctional cytosine-terminated supramolecular macromer, which forms nanosized spherical micelles with excellent structural stability and drug release performance after UV irradiation. Further in vitro studies demonstrated that the photodimerized cytosine moieties enhance the cellular uptake and induce apoptotic cell death of the drug-loaded micelles.
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Biochemistry & Molecular Biology
Min Li, Ling'e Zhang, Yang Xuan, Defu Zhi, Wei Wang, Wenjun Zhang, Yinan Zhao, Shufen Zhang, Shubiao Zhang
Summary: This study developed a pH-responsive tumor prodrug using hyaluronic acid as a targeting carrier. The prodrug micelles demonstrated excellent stability, blood compatibility, and drug release properties. In vivo experiments showed that the prodrug micelles had significant tumor inhibition activity with minimal systemic toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Jiangxiu Niu, Ming Yuan, Zhaowei Zhang, Liye Wang, Yanli Fan, Xianghui Liu, Xianming Liu, Huiyuan Ya, Yansong Zhang, Yang Xu
Summary: In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. The results showed that CUR-M had good physicochemical properties and stability, significantly enhanced the permeation and retention of CUR, and exhibited better analgesic and anti-inflammatory activities in vivo without causing skin irritation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Engineering, Biomedical
Timea B. B. Gandek, Luke van der Koog, Anika Nagelkerke
Summary: A key aspect for successful drug delivery via lipid-based nanoparticles is their internalization in target cells. Liposomes and EVs are the two prominent examples of such drug delivery systems. This review evaluates the internalization mechanisms of liposomes and EVs, as well as their intracellular fate. Opportunities to enhance the therapeutic efficacy of these systems are highlighted by tweaking these internalization mechanisms and intracellular fates.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Maghsoud Amirfarhangi Anbardan, Siamak Alipour, Gholam Reza Mahdavinia, Parisa Fathi Rezaei
Summary: The magnetic nanocarriers composed of chitosan/hyaluronic acid complexed with kappa-carrageenan were successfully synthesized and demonstrated as an efficient drug delivery system. The nanodelivery system showed high drug loading capacity and responsive drug release behavior under pH stimuli, while exhibiting no inhibitory effect on cell growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Kaikai Xu, Hai Yao, Di Fan, Lin Zhou, Shaohua Wei
Summary: DMSO acts as a solvent for anticancer drugs and participates in disulfide bond crosslinking to form a hydrogel for drug loading, enabling sustained drug release and tumor growth suppression.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Hong Yu Yang, Jia Meng Du, Moon-Sun Jang, Xin Wang Mo, Xin Shun Sun, Doo Sung Lee, Jung Hee Lee, Yan Fu
Summary: EPNGs were successfully fabricated for CD44-targeted transport of cytochrome c through UV-triggered chemical cross-linking, showing stable and high protein encapsulation efficiency in blood circulation and rapid release in targeted tumor cells.
Review
Pharmacology & Pharmacy
Afsaneh Farjami, Sara Salatin, Samira Jafari, Mohammad Mahmoudian, Mitra Jelvehgari
Summary: The skin provides a protective barrier against toxic environments and offers a valuable route for topical drug delivery. Nanoparticulate carriers have gained widespread attention due to their tunable and versatile properties. Monitoring the skin penetration of nanocarriers is crucial to avoid potential toxic effects and increase the permeability of drugs into the skin.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pharmacology & Pharmacy
Meysam Soleymani, Mohammad Velashjerdi, Mahsa Asgari
Summary: This study developed a facile method to prepare hyaluronic acid-decorated mixed nanomicelles loaded with curcumin for targeted therapy of breast cancer cells with high CD44 receptor expression. The targeted nanomicelles showed enhanced cytotoxicity of curcumin against cancer cells compared to non-targeted nanomicelles. These findings suggest that curcumin-loaded HA-PD mixed nanomicelles have potential as a promising targeted drug delivery system for breast cancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Chao Deng, Haitian Fu, Jingying Shang, Jinghua Chen, Xin Xu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biochemistry & Molecular Biology
Haitian Fu, Chao Deng, Liping Teng, Zhi Cai, Jinghua Chen, Guozhong Lu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biotechnology & Applied Microbiology
Quan Zhang, Rui Yao, Xiulai Chen, Liming Liu, Shuqin Xu, Jinghua Chen, Jing Wu
METABOLIC ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lu, Jinghua Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Multidisciplinary
Huijie Zhang, Mengxia Peng, Ting Cheng, Peng Zhao, Lipeng Qiu, Juan Zhou, Guozhong Lu, Jinghua Chen
JOURNAL OF MATERIALS SCIENCE
(2018)
Article
Materials Science, Biomaterials
Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Chemistry, Medicinal
Kamel S. Ahmed, Shenhuan Liu, Jing Mao, Jie Zhang, Lipeng Qiu
Summary: The study developed a multifunctional nano-structured liposomal system for co-delivery of doxorubicin and celecoxib to overcome doxorubicin resistance in breast cancer, showing remarkable treatment efficacy. The peptide-modified targeted liposomes exhibited strong cellular entry ability and mitochondrial-targeting effect, effectively inhibiting P-glycoprotein efflux activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen
Summary: The pH/reduction dual sensitive PCT polymers have been synthesized to promote rapid release of drug-loaded micelles at tumor site, showing strong cytotoxicity against tumor cells and better inhibitory effect on tumor growth compared to control micelles. The PCT micelles can be depolymerized in intracellular acidic and reductive environment to release drugs rapidly, indicating great potential for intercellular delivery of antitumor drugs.
Article
Nanoscience & Nanotechnology
Huijie Zhang, Airan Ding, Baoting Ye, Zhiqing Wang, Jiawen Zhang, Lipeng Qiu, Jinghua Chen
Summary: This study developed a multifunctional CpG ODN delivery system utilizing GCNNs and CS, which showed no cytotoxicity and efficient CpG ODN loading. CS-GCNNs significantly increased CpG ODN uptake in cells and triggered enhanced immunostimulation, with the added ability to stably trace the delivery process through cell imaging.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Biomedical
Lipeng Qiu, Jiamin Xu, Kamel S. S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Weijun Chen, Wenjie Fang, Huijie Zhang, Jinghua Chen
Summary: A dual-functional pH-sensitive drug delivery system was developed for breast cancer therapy. The system showed higher cytotoxicity and cell uptake efficiency compared to other drug-loaded micelles, indicating its potential for reversing multidrug resistance. In vivo experiments demonstrated that the system effectively inhibited tumor growth without significant changes in body weight. The results suggest that the dual gain DNVM can enhance the efficacy of chemotherapy for doxorubicin-resistant tumor cells and has the potential to overcome multiple drug resistance.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Meiyang Yang, Mariana Conceicao, Weijun Chen, Fuwei Yang, Bingke Zhao, Matthew J. A. Wood, Lipeng Qiu, Jinghua Chen
Summary: The development of an engineered bacteria delivery system that can distribute throughout the entire tumor and suppress metastasis is of great significance in cancer treatment improvement.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Wei Jun Chen, Dhanu Gupta, Meiyang Yang, Fuwei Yang, Ning Feng, Junling Song, Matthew J. A. Wood, Lipeng Qiu, Jinghua Chen
Summary: Metal-organic frameworks (MOFs) with tunable porosity, biocompatibility, and modularity have shown promise as novel therapeutics for malignancies. However, the design and synthesis of dual-stimuli responsive MOFs for controlled drug release in tumor microenvironments are challenging. This study synthesized pH/glutathione (GSH)-sensitive MnFe-based MOFs combined with gold nanoparticles (Au NPs) and cisplatin prodrugs (DSCP) for chemo-chemodynamic-starvation synergistic therapy.
Article
Engineering, Biomedical
Weijun Chen, Meiyang Yang, Jie Li, Zhilan Chen, Lefei Hu, Jiannan Zhang, Liangyu Cai, Lipeng Qiu, Jinghua Chen
Summary: A novel GSH-activatable Cu2+-Quercetin network loaded with Au nanoparticles and DOX was synthesized for the synergistic therapy of chemotherapy enhanced by chemotherapy and photothermal therapy. The multi-mode synergistic strategy showed excellent therapeutic effects in cancer cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Qingfeng Guo, Jie Li, Jing Mao, Weijun Chen, Meiyang Yang, Yang Yang, Yuming Hua, Lipeng Qiu, Dennis Douroumis, Alexander K. Andrianov
Summary: A multifunctional delivery system was prepared to reverse tumor multidrug resistance (MDR) by inhibiting drug efflux and autophagy. The system effectively inhibited drug efflux and autophagy, leading to enhanced therapeutic effects. In vitro and in vivo experiments demonstrated that the delivery system effectively inhibited tumor growth and induced death of drug-resistant cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Materials Science, Biomaterials
Meiyang Yang, Fuwei Yang, Weijun Chen, Shenhuan Liu, Lipeng Qiu, Jinghua Chen
Summary: Cancer therapy utilizing live tumor-targeting bacteria offers unique advantages, but the lack of understanding on mechanisms and side effects presents challenges in developing such microbial treatments.
BIOMATERIALS SCIENCE
(2021)
