Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease

Design, Synthesis, and Evaluation of Multitarget-Directed Selenium-Containing Clioquinol Derivatives for the Treatment of Alzheimer’s Disease

(2014) Zhiren Wang et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer’s disease

(2014) Zonghua Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Melatonin–N,N-Dibenzyl(N-methyl)amine Hybrids: Potent Neurogenic Agents with Antioxidant, Cholinergic, and Neuroprotective Properties as Innovative Drugs for Alzheimer’s Disease

(2014) Beatriz López-Iglesias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of (E)-3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents

(2014) Xianling Ning et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

(2013) Paul C. Trippier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen

(2013) Zonghua Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy

(2012) Jie He et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

(2012) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship of N-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors

(2012) Roberto Di Santo et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

l-Isofucoselenofagomine and derivatives: dual activities as antioxidants and as glycosidase inhibitors

(2012) Penélope Merino-Montiel et al.   TETRAHEDRON

Synthesis and Antioxidant Activity of Peptide-Based Ebselen Analogues

(2011) Kandhan Satheeshkumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, Structure, and Glutathione Peroxidase-Like Activity of Amino Acid Containing Ebselen Analogues and Diaryl Diselenides

(2011) Karuthapandi Selvakumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Glutathione Peroxidase-Like Activities of Isoselenazolines

(2011) Vijay P. Singh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organoselenium Chemistry: Role of Intramolecular Interactions†

(2010) Anna J. Mukherjee et al.   CHEMICAL REVIEWS

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue

(2010) Navin B. Patel et al.   Journal of Saudi Chemical Society

Cholinesterase Inhibitors and Beyond

(2009) Giancarlo Pepeu et al.   Current Alzheimer Research

Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

(2009) Pelayo Camps et al.   JOURNAL OF MEDICINAL CHEMISTRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties

(2008) Michael Decker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antioxidant Activity of the Anti-Inflammatory Compound Ebselen: A Reversible Cyclization Pathway via Selenenic and Seleninic Acid Intermediates

(2008) Bani Kanta Sarma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging

(2008) Paolo Zatta et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON