Article
Biochemistry & Molecular Biology
Jonathan H. Galarraga, Abhishek P. Dhand, Bruce P. Enzmann, Jason A. Burdick
Summary: Numerous chemical modifications of hyaluronic acid (HA) have been explored for the formation of degradable hydrogels that are suitable for various biomedical applications. Thiol-ene step-growth chemistry is of particular interest due to its lower oxygen sensitivity and ability to precisely tune mechanical properties. In this study, NorHACA hydrogels were synthesized through esterification of Norbornene-modified HA (NorHACA) and demonstrated high susceptibility to hydrolytic degradation. The mechanical properties and degradation timescales of NorHACA hydrogels were adjustable by macromer concentration and/or degree of modification. Additionally, NorHACA hydrogels were used as DLP resins for fabrication of hydrolytically degradable scaffolds and bioprinting of cell-laden constructs, showing great potential for tissue engineering and regenerative medicine applications.
Article
Chemistry, Applied
Woogi Hyon, Shuji Shibata, Etsuo Ozaki, Motoki Fujimura, Suong-Hyu Hyon, Kazuaki Matsumura
Summary: We developed a self-degradable medical adhesive, LYDEX, and elucidated its degradation mechanism by analyzing the main degradation products, which is valuable for clarifying other polysaccharide hydrogel degradation mechanisms and its medical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yiming Zhang, Yinghao Ding, Xinxin Li, Debin Zheng, Jie Gao, Zhimou Yang
Summary: Zwitterionic polymer materials have been extensively studied, but zwitterionic peptides supramolecular hydrogel materials are rarely studied. In this study, the preparation of two zwitterionic hydrogels using self-assembled peptides were reported. The differences in structure and function of the zwitterion peptide hydrogels caused by the two preparation methods were compared, with the enzyme induced self-assembly method showing better solubility and lower cytotoxicity.
CHINESE CHEMICAL LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Yixuan Huang, Tsukuru Masuda, Madoka Takai
Summary: The modifiable polymer gel composed of phosphorylcholine and N-hydroxysuccinimide ester can be postmodified to obtain a redox zwitterionic gel, which demonstrates superior operational stability and resistance to biofouling compared to typical redox hydrogels. The gel can serve as an enzyme-immobilizing matrix for enzymatic bioelectrodes, showing potential applications in the field of implantable bioelectronic applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
B. Wang, S. Peng, H. Chen, H. Ren, Y. Yan, Q. Zhang
Summary: The study found that coating the antibacterial magnesium gallate metal organic framework (Mg-MOF) with oxidized dextran/gelatin and doping it into composite bone cement can achieve sustained drug release, exhibit excellent antibacterial properties, and promote cell proliferation and osteogenic differentiation.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jaepil Jeong, So Young An, Xiaolei Hu, Yuqi Zhao, Rongguan Yin, Grzegorz Szczepaniak, Hironobu Murata, Subha R. Das, Krzysztof Matyjaszewski
Summary: This study presents an approach to convert biomass RNA into an acrylic crosslinker by acyl imidazole chemistry, allowing for the fabrication of materials with tunable properties. It also explores reversible-deactivation radical polymerization methods and metallization of the biomass RNA-based material, expanding the opportunities in biomass-based biomaterial fabrication.
Article
Chemistry, Multidisciplinary
Ke He, Pingqiang Cai, Shaobo Ji, Zihan Tang, Zhou Fang, Wenlong Li, Jing Yu, Jiangtao Su, Yifei Luo, Feilong Zhang, Ting Wang, Ming Wang, Changjin Wan, Liang Pan, Baohua Ji, Dechang Li, Xiaodong Chen
Summary: Hydrogels are crucial for on-skin healthcare devices, but their dehydration is a limiting factor. This study presents an antidehydration hydrogel with superior hydrating zwitterionic oligomers. It excels in preventing dehydration and skin penetration, while ensuring stable signal acquisition under low-humidity conditions. It holds potential for epidermis-safe on-skin devices.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Mahsasadat Mostafavi Esfahani, Narjes Koupaei, Seyed Ali Hassanzadeh-Tabrizi
Summary: The aim of this study was to synthesize and characterize polyvinyl alcohol/dextran/Zataria essential oil hydrogel wound dressings. The addition of dextran and Zataria essential oil significantly influenced the properties of the hydrogel films. The incorporation of Zataria essential oil improved cell viability and the antimicrobial activity of the films.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Ye Wang, Changyuan He, Chong Chen, Wentao Dong, Xuekun Yang, Ye Wu, Qingquan Kong, Bin Yan
Summary: In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Characterization & Testing
Liang Li, Jixiang Guo, Ruiying Xiong
Summary: A physically cross-linked high strength hydrogel that can be completely degraded was prepared by micellar copolymerization, using acrylic acid and octadecyl acrylate as the hydrophobic monomers. The hydrogel degrades completely under alkaline conditions, with higher temperatures leading to faster degradation, while high salinity hinders degradation efficiency.
Article
Chemistry, Physical
Juan Zeng, Hao Chen, Liubing Dong, Lu Wei, Xin Guo
Summary: In this study, a new type of anti-freezing hydrogel electrolyte was proposed by adding zwitterionic proline, which enables high ionic conductivity in hydrogel electrolytes at subzero temperatures. The unique structure of the proline electrolytes leads to strong hydration, ionic interactions, and low self-associations, resulting in excellent performance at low temperatures. The proline hydrogel electrolytes show high ionic conductivity and good low-temperature adaptability, making them suitable for anti-freezing energy storage devices.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Naglaa Salem El-Sayed, Muhammad Imran Sajid, Keykavous Parang, Rakesh Kumar Tiwari
Summary: A novel drug delivery system based on myristoylated ECGKRK peptide-decorated dextran was successfully synthesized in this study, showing the ability to self-assemble into nanoparticles and potential non-toxicity in various cancer cell lines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Takanori Yokoi, Akinori Kuzuya, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong, Yuichi Ohya
Summary: A study developed a DN gel that exhibited high mechanical strength and biodegradability, making it potentially useful in biomedical applications. The gel was prepared using polyelectrolyte stents and degradable ester bonds, and showed promise as an implantable biomedical material.