Article
Biochemistry & Molecular Biology
Timea Claudia Ghitea
Summary: The study shows that anti-inflammatory diet therapy helps reduce gingival inflammation, decrease the development of pathogenic bacteria, and improve periodontal diseases. By reducing fat mass and inflammatory mediators, it contributes to the reduction of chronic diseases.
Article
Oncology
Kelly R. V. Villafuerte, Felipe T. Dantas, Mario Taba, Michel Messora, Francisco J. Candido dos Reis, Helio H. A. Carrara, Cristhiam de Jesus H. Martinez, Thais Gozzo, Daniela Bazan Palioto
Summary: This study found that NSPT can reduce levels of IL-2, TNF-alpha, and TGF-beta in the BC/P group, while in the P group, levels of INF-gamma, IL-2, TNF-alpha decreased and TGF-beta increased. At 180 days, IL-6 in GCF was significantly positively correlated with PD and CAL in the BC/P group, while in the P group, IL-1 beta in GCF was positively correlated with PD and CAL at 45 days.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Dentistry, Oral Surgery & Medicine
Yuwei Zhang, Ru Jia, Yifei Zhang, Xuefei Sun, Yukun Mei, Rui Zou, Lin Niu, Shaojie Dong
Summary: This systematic review and meta-analysis evaluated the effects of non-surgical periodontal therapy on inflammatory-related cytokines/adipocytokines in periodontitis patients with or without obesity. The results showed that non-surgical periodontal therapy can shift the levels of specific pro-inflammatory mediators and anti-inflammatory mediators in biological fluids.
Article
Dentistry, Oral Surgery & Medicine
Chun-Ping Hao, Nan-Jue Cao, Yu-He Zhu, Wei Wang
Summary: This study compared the cytokine profiles of periodontitis patients with and without smoking habits, and found that smoking may affect the immune response of periodontitis patients and impair the effectiveness of periodontal therapy.
Review
Dentistry, Oral Surgery & Medicine
M. G. Balta, E. Papathanasiou, I. J. Blix, T. E. Van Dyke
Summary: Periodontitis is the sixth-most prevalent disease in the world and the leading cause of tooth loss in adults. Recent studies have shown that synthetic and biological disease-modifying antirheumatic drugs, such as rituximab and tocilizumab, can improve periodontal clinical parameters. Probiotics and nutritional supplements have also been found to provide anti-inflammatory benefits in the treatment of periodontitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Immunology
Victor Vaernewyck, Boaz Arzi, Niek N. Sanders, Eric Cox, Bert Devriendt
Summary: Periodontal disease affects a large portion of adults and can lead to systemic disorders. Control options primarily focus on removing plaque and calculus, but altering host inflammatory response and reducing bacterial triggers are also important. Vaccines may provide a potent adjunct to mechanical debridement for prevention and treatment, but the complexity of periodontal disease complicates vaccine development. Recent advances in mucosal vaccination may help bridge this gap.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
D. Clark, B. Halpern, T. Miclau, M. Nakamura, Y. Kapila, R. Marcucio
Summary: The prevalence of periodontal disease increases with age, likely due to systemic inflammatory dysregulation. Age-related changes to macrophages may have a detrimental effect on disease recovery in aging populations, contributing to the pathogenesis of periodontal disease.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Ana Maria Ramirez-Pena, Arturo Sanchez-Perez, Matilde Campos-Aranda, Francisco Javier Hidalgo-Tallon
Summary: This study assessed the effectiveness of ozone therapy as an adjunct to mechanical therapy in periodontitis patients. The results showed that ozone treatment significantly reduced the gingival index, improved clinical attachment, reduced mobility, and showed significant differences in subgingival flora. This suggests that ozone therapy is effective and well tolerated in cases of generalized chronic periodontitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xu Wang, Yuxin Tong, Jiayu Zhang, Nazia Khan, Kaili Zhang, Huihui Bai, Qianqian Zhang, Yue Chen
Summary: This study investigates neuroinflammation under different periodontal statuses. Both the Lig group and Lps group showed notable microgliosis and astrogliosis, with a positive correlation between periodontal inflammation and the number of glial cells. Furthermore, expressions of IL-1 beta and TNF-alpha were significantly increased in the Lps group.
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Josephine Bayliss-Chapman, Hiten Halai, Cheryl Somani, Janet Davies, Philip Ancliff, Nikolaos Donos
Summary: The study found that children with neutrophil-related primary immunodeficiencies (PIDs) had a higher prevalence of periodontal disease, but severe periodontitis was rare. PIDs were also associated with a history of oral ulcers. Improvements in periodontal parameters were seen following oral hygiene instructions and non-surgical periodontal therapy.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hillary N. Wright, Elizabeth T. Mayer, Thomas E. Lallier, Pooja Maney
Summary: This study compared the clinical outcomes of using a periodontal endoscope versus loupes for scaling and root planing. The results showed that the periodontal endoscope was more effective in multirooted sites.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Medicine, General & Internal
Rosana Costa, Blanca Rios-Carrasco, Luis Monteiro, Paula Lopez-Jarana, Filipa Carneiro, Marta Relvas
Summary: Gingivitis and periodontitis are chronic inflammatory diseases affecting the supporting tissues of the teeth, and their pathogenesis can be influenced by factors such as bacterial biofilms, smoking, drugs, and systemic diseases. This study aims to analyze the association between periodontal status and type 1 diabetes mellitus. The results show a confirmed association between type 1 diabetes mellitus and periodontal diseases, with higher prevalence and severity in diabetic patients compared to healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daline Oliveira Carneiro, Isaac Suzart Gomes-Filho, Simone Seixas da Cruz, Soraya Castro Trindade, Kionna Oliveira Bernardes Santos, Viviane Almeida Sarmento, Taciane Oliveira Bet Freitas, Heloisa Lais Rosario dos Santos, Alexandre Marcelo Hintz, Pedro Nascimento Prates Santos, Ana Claudia Morais Godoy Figueiredo, Peter Michael Loomer, Johelle de Santana Passos-Soares
Summary: This cross-sectional study investigates the association between excess body weight and periodontitis in adults. The results reveal a positive association between obesity and periodontitis in women and younger individuals. The high prevalence of overweight, obesity, and periodontitis is emphasized.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Dentistry, Oral Surgery & Medicine
F. Cavalla, A. Letra, R. M. Silva, G. P. Garlet
Summary: Periodontal and periapical lesions are infectious inflammatory osteolytic conditions mediated by a complex inflammatory immune response. The RANKL/OPG ratio plays a key role in determining osteolytic activity, which can be modulated by proinflammatory cytokines and effector cells. Understanding the molecular mechanisms associated with host response and immunological tolerance is crucial for the management of lesion activity.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Immunology
Daniel Belstrom, Florentin Constancias, Merete Markvart, Martin Sikora, Christiane Elisabeth Sorensen, Michael Givskov
Summary: The study demonstrates that the transcriptional activity of predominant Streptococcus species is influenced by specific ecological conditions and the presence of periodontitis in the oral microbiota. Certain Streptococcus species show higher transcriptional activity in saliva in orally healthy individuals and lower activity in patients with periodontitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Environmental Sciences
Luiz Alexandre Chisini, Francine dos Santos Costa, Luana Carla Salvi, Victorio Poletto Neto, Rodrigo Varella de Carvalho, Flavio Fernando Demarco
Summary: This study analyzed the impact of the COVID-19 pandemic on the rates of periodontal procedures in the Brazilian Public Health System. It found a significant reduction in the number of periodontal procedures during the pandemic, although the reduction was not as great as that of medical and general dental procedures. Medical procedures experienced the sharpest drop in procedures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sarah Arangurem Karam, Francine dos Santos Costa, Marcos Britto Correa, Andrea D. Bertoldi, Fernando C. Barros, Flavio Fernando Demarco
Summary: A study from Brazil's birth cohort revealed socioeconomic disparities in maternal perception of children's oral health and the prevalence of untreated dental caries in children. Poorer families and mothers with lower educational levels were more likely to have negative perceptions of children's oral health.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vanessa Polina Pereira Costa, Marilia Leao Goettems, Luciana Quevedo, Jason Armfield, Ricardo Tavares Pinheiro, Flavio Fernando Demarco
Summary: Maternal anxiety disorders, particularly agoraphobia and social phobia, are associated with dental fear in children. Detection and treatment of maternal mental disorders may help prevent dental fear and its related consequences.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Susilena Arouche Costa, Cecilia Claudia Costa Ribeiro, Fabio Renato Manzolli Leite, Marco A. Peres, Soraia de Fatima Carvalho Souza, Gustavo G. Nascimento
Summary: The aim of this study was to investigate the relationship between caries and periodontitis indicators among Americans across different age groups. A cross-sectional study was conducted on 14,421 participants, and the grouping of these indicators was explored. The results showed consistent grouping patterns across different age ranges.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
F. R. M. Leite, R. Lopez, J. B. Pajaniaye, G. G. Nascimento
Summary: This study investigated the influence of different levels of smoking on periodontal healing and found that heavy smokers had worse periodontal parameters compared to light smokers/quitters and moderate smokers after nonsurgical periodontal therapy. Therefore, smoking cessation should be included in periodontal therapy to achieve optimal treatment outcomes.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fabio R. M. Leite, Rodrigo Lopez, Holger J. Moller, Gustavo G. Nascimento
Summary: This study aimed to describe cytokine profiles in periodontal healing after periodontal therapy in smokers. The results suggest that different smoking trajectories have distinct effects on cytokine expression, which in turn influence periodontal repair.
JOURNAL OF PERIODONTOLOGY
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Helena Silveira Schuch, Gustavo Giacomelli Nascimento, Flavio Fernando Demarco, Dandara Gabriela Haag
Summary: Causal inference plays a crucial role in studying oral health interventions and guiding policy-making by identifying the actual causes of oral conditions. However, methodological deficiencies limit the interpretability and application of findings in oral health research. It is necessary to ask theoretically sound questions, define causal relationships, and accurately measure the outcomes to improve the quality of studies.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Thais Freitas Formozo Tillmann, Maria Beatriz Junqueira de Camargo, Andreia Morales Cascaes, Aluisio J. D. Barros, Ina S. Santos, Marcos Britto Correa, Alicia Matijasevich, Otavio Pereira D'avila, Alexandre Emidio Ribeiro Silva
Summary: The perception of parents or caregivers regarding the need for dental appointments for adolescents aged 12-13 years is associated with oral health problems. Effective oral health programs are needed to enhance the understanding of parents and caregivers regarding the importance of comprehensive care for their adolescent children.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leandro Machado Oliveira, Camila Silveira Sfreddo, Thiago Machado Ardenghi, Gustavo G. Nascimento, Flavio Fernando Demarco, Fabricio Batistin Zanatta
Summary: This study examines the impact of income inequalities on tooth loss in older Brazilian adults and finds that low-income individuals are more susceptible to the effects of heavy drinking on tooth loss.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
F. V. Bitencourt, G. G. Nascimento, S. A. Costa, A. Andersen, A. Sandbaek, F. R. M. Leite
Summary: Periodontitis is associated with diabetes mellitus and may be one of its complications. This study found that periodontitis clusters with other diabetes-related complications such as cardiovascular diseases, proteinuria, and hypertension. The findings suggest that periodontal tissue breakdown can serve as a valuable screening tool for other well-known diabetes-related complications.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Computer Science, Information Systems
Siqi Li, Pinyan Liu, Gustavo G. Nascimento, Xinru Wang, Fabio Renato Manzolli Leite, Bibhas Chakraborty, Chuan Hong, Yilin Ning, Feng Xie, Zhen Ling Teo, Daniel Shu Wei Ting, Hamed Haddadi, Marcus Eng Hock Ong, Marco Aurelio Peres, Nan Liu
Summary: This review examines the application of federated learning (FL) on structured medical data, identifies limitations, and discusses potential innovations. Out of 34 included articles, most utilized data from electronic health records and focused on clinical predictions and association studies. However, there is a lack of sufficient evaluation of clinically meaningful benefits and comparisons with single-site analyses. Future FL applications should prioritize clinical motivations and develop designs and methodologies to support clinical practice and research effectively.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Lorena Lucia Costa Ladeira, Gustavo Giacomelli Nascimento, Fabio Renato Manzolli Leite, Silas Alves-Costa, Janaina Maiana Abreu Barbosa, Claudia Maria Coelho Alves, Erika Barbara Abreu Fonseca Thomaz, Rosangela Fernandes Lucena Batista, Cecilia Claudia Costa Ribeiro
Summary: This study investigated the relationship between obesity and insulin resistance with caries and periodontitis, and found that obesity and insulin resistance were associated with chronic oral disease burden. Behavioral risk factors were also found to be associated with increased chronic oral disease burden.
Article
Dentistry, Oral Surgery & Medicine
Yorrana Martins Correa, Renata Uliana Posser, Sarah Arangurem Karam, Francine dos Santos Costa, Falk Schwendicke, Flavio Fernando Demarco, Marcos Britto Correa
Summary: This longitudinal study aimed to investigate the relationship between self-perceived oral health, oral-health-related quality-of-life (OHRQoL), toothache, and university students' academic performance or dropout. The study found that worse oral health conditions may be associated with worse academic performance or dropping out.
BRAZILIAN ORAL RESEARCH
(2023)
