Journal
RSC ADVANCES
Volume 6, Issue 80, Pages 76498-76504Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra14640f
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Funding
- National Natural Science Foundation of China [41176120, 21372208]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
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Four new tetralone derivatives, clindanones A and B (1 and 2) and cladosporols F and G (3 and 4), together with three known biogenetically related polyketides (5-7), were isolated from the deep-sea derived fungus Cladosporium cladosporioides HDN14-342. The structures of 1-4, including absolute configurations, were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. The absolute configurations of the known cladosporols C (5) and E (6) were also revised. Compounds 1 and 2 possessed new dimeric forms of the skeleton composed by coupling of indanone and 1-tetralone units, and 4 showed the best cytotoxic activity against HeLa cells with an IC50 value of 3.9 mu M.
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