Journal
RSC ADVANCES
Volume 6, Issue 23, Pages 19475-19481Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra25071d
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- Deanship of Scientific Research at King Saud University, Riyadh, Saudi Arabia [RGP-150]
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Two new complexes of copper(II), [CuL2], and zinc(II), [ZnL2], with a tridentate -ONN' -Schiff base ligand (L), a bioactive scaffold derived from 2-aminobenzimidazole and 2-hydroxy-3-methoxybenzaldehyde, were synthesized and characterized using various spectroscopic techniques, viz, IR, H-1 and C-13 NMR, EPR, HRMS, and elemental analysis and purity analysis using UPLC studies. Both the complexes are non-electrolytic by nature. The newly synthesized compounds were screened for acetic acid-induced analgesic and yeast-induced antipyretic activities in mice and carrageenan-induced paw edema in rats (anti-inflammatory). The results showed that the [CuL2] compound (at 100 mg kg(-1) b.w) possessed potent anti-inflammatory activity whereas [ZnL2] (at 50 mg kg(-1) and 100 mg kg(-1) b.w) exhibited significant analgesic activity when compared with standard drugs. Both the complexes have apparently moderate and nearly akin antipyretic activity.
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