Journal
RSC ADVANCES
Volume 6, Issue 22, Pages 17921-17928Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra26255k
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Funding
- National Natural Science Foundation of China [61273243, 51407095]
- Program of Natural Science Research of Jiangsu Higher Education Institutions of China [14KJB480004]
- Program of Natural Science Foundation of Jiangsu Province [BK20150973]
- Fundamental Research Funds for the Central Universities
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Paper microfluidic devices are a promising technology in developing analytical devices for point-of-care diagnosis in the developing world. This article describes a novel method of wax jetting with a PZT (piezoelectric ceramic transducer) actuator and glass nozzle for the fabrication of paper microfluidic devices. The hydrophobic fluid pattern was formed by the permeation of filter paper with wax droplets. Results showed that the size of the wax droplet, which was determined by the voltage of the driving signal and nozzle diameter, ranged from 150 mu m to 380 mu m, and the coefficient of variation of the droplet diameter was under 4.0%. The smallest width of the fluid channel was 600 mu m frontside and 750 mu m backside. The patterned filter paper was without any leakage, and multi-assay of glucose, protein, and pH on the paper microfluidic device, and laminar diffusion flow with blue and yellow dye were realized. The wax jetting system supplied a low-cost, simple, easy-to-use and fast fabrication method for paper microfluidic devices.
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