Article
Computer Science, Interdisciplinary Applications
Hao Sun, Bao Li, Jincheng Liu, Xiaolu Xi, Liyuan Zhang, Yanping Zhang, Guangfei Li, Huamei Guo, Kenan Gu, Tongna Wang, Chuanqi Wen, Youjun Liu
Summary: This study established a lumped-parameter model (BTM-LPM) of brain tissue microcirculation based on computed tomography angiography (CTA), which can accurately calculate cerebral perfusion in real time and demonstrate the importance of Circle of Willis anatomy in different ischemic injuries to cerebral tissue. The calculated cerebral perfusion would serve as a reference value for early diagnosis and preoperative planning of different ischemic injuries to cerebral tissue, showing great potential for replacing computed tomography perfusion (CTP) examination.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Cardiac & Cardiovascular Systems
Yanfang Liu, Yufeng Li, Jiankun Zang, Tianyuan Zhang, Yaojie Li, Zefeng Tan, Dan Ma, Tao Zhang, Shiyong Wang, Yusheng Zhang, Lian Huang, Yousheng Wu, Xuanlin Su, Zean Weng, Die Deng, Chi Kwan Tsang, Anding Xu, Dan Lu
Summary: CircOGDH may serve as a potential biomarker for penumbra in AIS patients and play a role in ischemic neuronal damage. CircOGDH interacts with miR-5112, enhancing COL4A4 expression and exacerbating neuron damage. Knockdown of CircOGDH enhances neuronal cell viability under ischemic conditions. Additionally, CircOGDH is enriched in neuron-derived exosomes in peripheral blood.
CIRCULATION RESEARCH
(2022)
Article
Health Care Sciences & Services
Lily Chau, Herbert T. Davis, Thomas Jones, Diana Greene-Chandos, Michel Torbey, C. William Shuttleworth, Andrew P. Carlson
Summary: In this study, the association between physiological variables and the risk of spreading depolarization (SD) in malignant hemispheric stroke (MHS) patients was explored. It was found that increased ETCO2 and DBP were protective against SD, while elevated temperature and WBC were associated with an increased risk of SD. Additionally, the use of ketamine was found to completely inhibit SD in one patient. These findings suggest that physiological optimization strategies and/or pharmacologic therapy could potentially inhibit SD in MHS patients and limit edema and infarct progression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Melissa J. Visser, Joseph Yuan-Mou Yang, Fernando Calamante, Michael Kean, Christopher L. Adamson, Gagan Sharma, Vicki Anderson, Bruce C. V. Campbell, Mark T. Mackay
Summary: This study demonstrated the feasibility of rapidly assessing perfusion-diffusion mismatch in childhood AIS using automated software and identified some children with favorable mismatch profiles. The results suggest potential therapeutic benefit of RAPID use beyond the standard 4.5 hours window for thrombolysis. Further research is needed to determine the utility of perfusion-based imaging for guiding clinical decision making, whether adult thresholds need modification in childhood AIS, and the impact of time-delay and cause on mismatch characteristics.
Article
Engineering, Biomedical
Shasha Yao, Chengbin He, Pengcheng Yuan, Xiaodan Xu, Xiaoxuan Zhou, Liyin Shen, Qiuhui Hu, Nigel K. H. Slater, Wenjing Sun, Youqing Shen, Hongjie Hu, Jianbin Tang
Summary: Rapid and comprehensive assessment of ischemic stroke (IS) is crucial for clinicians to provide appropriate treatment. Currently, IS assessment relies on computed tomography and magnetic resonance imaging, along with clinical symptoms and contraindication inquiries. However, these methods cannot diagnose pathology or assess the microenvironment in real-time. This study develops a pH-responsive fluorescent liposomal probe for visualizing the degree of IS based on acid microenvironments. The fluorescence imaging with this probe provides a new method for objectively evaluating IS severity and offers insights into the relationship between acidic microenvironments and IS progression.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Di Su, Ran Zhang, Xin Wang, Qi Ding, Feida Che, Wen Zhang, Wei Wu, Ping Li, Bo Tang
Summary: This study constructed a new multi-parameter simultaneous fluorescence imaging platform for evaluating the efficacy of new drugs for ischemic stroke. Through simultaneous fluorescence observation of three key indicators, real-time and in-situ evaluation of drug efficacy was performed. The results showed that edaravone dexborneol had better therapeutic effect compared to the other two drugs using this platform.
Article
Clinical Neurology
Laurens Winkelmeier, Tobias D. Faizy, Gabriel Broocks, Lukas Meyer, Christian Heitkamp, Caspar Brekenfeld, Christian Thaler, Paul Steffen, Maximilian Schell, Milani Deb-Chatterji, Uta Hanning, Helge Kniep, Mate E. Maros, Goetz Thomalla, Jens Fiehler, Fabian Alexander Flottmann
Summary: The clinical benefit of endovascular therapy in patients with large ischemic stroke is associated with the number of recanalization attempts. At least 2 recanalization attempts improve the likelihood of favorable functional outcomes, while more than 2 attempts should be carefully assessed.
Article
Clinical Neurology
Zi-Ai Zhao, Nan-Nan Zhang, Lin Tao, Yu Cui, Meng Li, Shou-Liang Qi, Hui-Sheng Chen
Summary: This study observed the effect of head-down tilt on AIS patients and found that in cases with END, head-down tilt helped prevent further neurological deterioration and improve clinical outcomes. Cerebral perfusion imaging also showed an increase in cerebral blood flow after head-down tilt treatment.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Malgorzata Szczuko, Igor Koziol, Dariusz Kotlega, Jacek Brodowski, Arleta Drozd
Summary: Cardiovascular diseases are leading causes of morbidity and mortality in developed countries, with ischemic stroke being a significant disorder. Acetylsalicylic acid (ASA) is a treatment modality that blocks cyclooxygenase, and measuring thromboxane B2 in serum is a potential biomarker of vascular disease risk. Further research is needed to determine the effectiveness of thromboxane as a clinical marker for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jiali Gao, Zhen Jing, Shengming Huang, Jiajie Yang, Min Guan, Shijun Zhang, Hao Li, Yongxin Li, Kui Lu, Ming Yang, Li'an Huang
Summary: This study compared the time efficiency and clinical outcomes of AIS patients who underwent EVT before one-stop ASL and CTP protocols. The results showed no significant differences in time efficiency and efficacy outcomes between the two groups. However, the proportion of sICH at 24 h and EVT complications in the CTP group were lower than the ASL group. Ischemic core volume was an independent predictor for favorable outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jiali Xu, Qian Zhang, Gary B. Rajah, Wenbo Zhao, Fang Wu, Yuchuan Ding, Bowei Zhang, Wenting Guo, Qi Yang, Xiurong Xing, Sijie Li, Xunming Ji
Summary: This study aimed to prove the safety and efficacy of remote ischemic conditioning (RIC) on Moyamoya disease (MMD). The results showed that RIC can improve cerebral blood flow and slow down the progression of stenotic-occlusive lesions in MMD patients, making it a potential safe and effective adjunctive therapy for MMD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Khan Haroon, Huitong Ruan, Haoran Zheng, Shengju Wu, Ze Liu, Xiaojing Shi, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhang
Summary: Delivering large therapeutic molecules to the brain for the treatment of ischemic stroke is challenging. In this study, the researchers developed a targeted delivery system using small extracellular vesicles (sEVs) loaded with a neuroprotective peptide called NR2B9c. The sEVs were modified with a rabies virus glycoprotein to improve brain targeting. In vitro and in vivo experiments showed that the sEVs-COCKTAIL exhibited potential against reactive oxygen species and cellular apoptosis, resulting in increased behavioral recovery and reduced neuronal apoptosis after stroke. The study provides a promising modality for stroke therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Clinical Neurology
Benjamin Beland, Fouzi Bala, Aravind Ganesh
Summary: A systematic review and meta-analysis found that patients with prestroke disability who received IVT treatment had better odds of returning to baseline function compared to those who did not receive treatment. There were no significant differences in mortality and sICH rates between treated and untreated patients with disability. Further high-quality data comparing treated and untreated patients with prestroke disability are needed to clarify the issue.
Review
Nanoscience & Nanotechnology
Yun Chen, Fangfang Yu, Yihan Wang, Weiwei Liu, Jing Ye, Jiang Xiao, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: This review discusses the recent advances, perspectives, and challenges of noble metal nanomaterials in SERS assays, focusing on their applications in early cancer diagnosis.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Jiayu Zeng, Zengchao Guo, Yihan Wang, Zhaojian Qin, Yi Ma, Hui Jiang, Yossi Weizmann, Xuemei Wang
Summary: Bacterial infections are a growing health issue, and timely diagnosis and treatment are crucial. This paper presents a multifunctional nanotheranostics platform based on the unique micro-environment of bacterial infections, which allows for bacterial bioimaging and simultaneous inactivation. The experiments show that the self-assembled nanoclusters can emit fluorescence in bacterial infections and efficiently sterilize bacteria through multiple mechanisms. Furthermore, the nanotheranostics platform exhibits good performance in in vivo tests and accelerates wound healing in bacterial infections.
Article
Chemistry, Multidisciplinary
Maonan Wang, Zengchao Guo, Jiayu Zeng, Liu Liu, Yihan Wang, Jinpeng Wang, Hongbing Lu, Haijun Zhang, Hui Jiang, Xuemei Wang
Summary: This study found that KRAS is highly expressed in pancreatic cancer tumors and is closely related to poor patient prognosis. A smart bio-responsive nanomedicine was proposed to target-deliver KRAS shRNA and achieve cancer cell diagnosis and treatment through a special oxidative stress-responsive effect.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Jincheng Li, Zengchao Guo, Tengfei Liu, Fangfang Yu, Jiayu Zeng, Ying Zhang, Lihong Yin, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Carbon dots (CDs) are a promising class of carbon-based luminescence materials with good dispersity, stability, low toxicity, and biocompatibility. This study successfully synthesized folic acid-modified cerium-doped CDs (Ce-CDs-FA) using a facile one-step hydrothermal method and demonstrated their potential as a sensitive fluorescent nanoprobe for cancer cell detection. Additionally, the Ce-CDs-FA nanocomposites showed a specific and hypersensitive quenching effect for Fe3+ ions, offering a possibility for the detection of iron ions.
Article
Chemistry, Multidisciplinary
Tianyu Du, Zewen Shi, Zhaojian Qin, Yiwei Hu, Yabin Zhu, Hui Jiang, Xuemei Wang
Summary: This study proposes an in situ targeted therapy strategy using a photothermally triggered nanoplatform. The nanoplatform, consisting of spherical nucleic acids, black phosphorus nanosheets, and zinc porphyrin metal-organic framework nanosheets, can disassemble during photothermal therapy, allowing for photothermally triggered photodynamic therapy. The enhanced singlet oxygen generation decreases heat shock proteins and improves the therapeutic effect. The superstructure shows potential as a synergistic platform for advanced cancer theranostics.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Yihan Wang, Huan Feng, Jinfeng Quan, Ke Huang, Jinpeng Wang, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: In this study, an enzyme-assisted cyclic amplification strategy was developed for the electrochemical detection of microRNAs (miRNAs) in serum. The strategy achieved highly sensitive detection of miRNAs with a low limit of detection through a catalytic hairpin assembly (CHA) reaction. This method has the potential for clinical miRNA analysis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Biomedical
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Summary: Exosome application is a promising nanotechnology discipline for disease therapy and diagnosis. Due to their natural properties, such as efficient drug delivery and blood-brain barrier traversing ability, exosomes have gained attention in clinical translation for brain diseases treatment.
Article
Engineering, Environmental
Zengchao Guo, Jiang Xiao, Weiwei Liu, Yihan Wang, Tengfei Liu, Hui Jiang, Xiaohui Liu, Xuemei Wang
Summary: Researchers have developed a multimode and broad-spectrum antimicrobial system based on cationic polypeptides and in situ self-assembled strategy. This system can effectively kill bacteria under irradiation and demonstrates high biocompatibility.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hao Liu, Zhiming Liu, Yihan Wang, Jiang Xiao, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: The biomineralization of tunable gold nanocrystals with in situ protein coronas by intracellular liquid-liquid phase separation (LLPS) was achieved for in situ molecule surface-enhanced Raman spectrum (SERS) analysis and tumor fluorescence identification. Anisotropic gold nanocrystals were obtained by regulating LLPS, allowing for directional growth and differentiation of clinical tumor tissue samples. This study reveals the mechanism of intracellular tunable nanocrystal biomineralization and provides the basis for its biomedical application.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Jinpeng Wang, Qingxiu Xia, Ke Huang, Lihong Yin, Hui Jiang, Xiaohui Liu, Xuemei Wang
Summary: In this study, an ultrafast, specific, and accurate cancer cell imaging strategy based on dynamically self-assembling fluorescent nanoclusters was developed. It can rapidly and accurately distinguish lung cancer cells from normal cells within 1 minute, and has been validated in alveolar lavage fluid samples from lung cancer patients. This strategy provides a safe and promising cancer diagnostic platform for cancer therapy.
Article
Engineering, Environmental
Yi Han Wang, Ke Huang, Zhao Jian Qin, Hong Jie Xiong, Teng Fei Liu, Ting Ya Wang, Xiang Dong Lai, Xiao Hui Liu, Hui Jiang, Xue Mei Wang
Summary: In this study, a unique cancer microenvironment responsive bioreactor was constructed to form fluorescent and magnetic nanocomposites of the Au&Fe3O4-DNA complexes in situ. The Au&Fe3O4-DNA complexes efficiently inhibited tumor growth by consuming intracellular glutathione, inducing oxidative stress injury and activating apoptosis. Moreover, this system allowed enhanced photothermal therapy under near-infrared light irradiation, providing a promising approach for cancer early diagnosis and efficient treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Analytical
Xinyi Xu, Xuemei Wang, Hui Jiang
Summary: This review focuses on the promoting effect of biosensing technology on the diagnosis and treatment of diabetes mellitus. The types of diabetes and their corresponding pathogeneses are introduced, followed by the diabetes prevalence and research progress at home and abroad. Breakthrough technology based on biosensing technology in the field of diabetes diagnosis and treatment is summarized. Diversified ways of blood glucose detection and multiple combinations of diabetes biomarkers are discussed for diagnosis, while various insulin administration routes and non-drug treatment means are presented for treatment. The prospect of the future development of diabetes diagnosis and treatment is put forward at the end of the review.
Review
Chemistry, Multidisciplinary
Hongjie Xiong, Liu Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Aptamers have excellent molecule-targeting ability and are promising candidates for cancer immunotherapy due to their advantages over monoclonal antibodies. By combining tumor- and immune cell-targeting aptamers, multivalent bispecific aptamers were designed to enhance immune efficacy. Aptamers can also be combined with nanomaterials and immune cells, showing potential in targeted cargo delivery, regulation of cell-cell interactions, and tumor immunogenicity activation.
CHEMISTRY-SWITZERLAND
(2023)
Article
Chemistry, Analytical
Fangfang Yu, Yihan Wang, Tengfei Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Hypochlorite plays an important role in biological systems and daily life. A new method for the detection of hypochlorite in living cells was developed using EY/UiO-66-NH2 as a self-calibrating sensing nanoprobe. The EY/UiO-66-NH2 probe exhibited a wide linear range, low detection limit, turn-on fluorescence, and ratiometric response, making it advantageous over previously reported probes.
Article
Nanoscience & Nanotechnology
Weiwei Liu, Farouk Semcheddine, Zengchao Guo, Hui Jiang, Xuemei Wang
Summary: In this study, a high-efficiency green antitumor method was reported, involving the in situ synthesis of composite nanoparticles with high catalytic efficiency and surface modification with folic-acid-conjugated bovine serum albumin for enhanced tumor cell recognition. These composite nanoparticles efficiently killed tumor cells through a starvation-nitric oxide synergistic process.
ACS APPLIED BIO MATERIALS
(2022)
