Article
Biochemistry & Molecular Biology
Maram Almohaywi, Bruna M. Sugita, Ariana Centa, Aline S. Fonseca, Valquiria C. Antunes, Paolo Fadda, Ciaran M. Mannion, Tomilowo Abijo, Stuart L. Goldberg, Michael C. Campbell, Robert L. Copeland, Yasmine Kanaan, Luciane R. Cavalli, Tiziana Squillaro, Mauro Finicelli
Summary: Studies suggest that deregulated miRNA expression in TNBC patients may correlate with aggressive phenotype. A panel of 28 miRNAs associated with copy number alterations were identified in TNBC biopsies from Latina women, with miR-182-5p being the most discriminatory. Up-regulation of miR-141-3p was linked to increased cancer recurrence, while down-regulation of miR-661 and miR-150-5p were associated with larger tumor size and other clinical factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Miquel Ensenyat-Mendez, Maria Solivellas-Pieras, Pere Llinas-Arias, Sandra Iniguez-Munoz, Jennifer L. Baker, Diego M. Marzese, Maggie L. DiNome
Summary: This study aims to investigate the epigenetic differences in triple-negative breast cancer (TNBC) of younger African American females and understand the clinical disparities in this patient group. The results suggest that TNBC of younger African American females may have distinct epigenetic characteristics and provide novel insights into the molecular alterations associated with TNBC in this population.
Article
Cell Biology
Maoni Guo, San Ming Wang
Summary: A computational approach was developed to identify a prognostic signature of 11 genes in TNBC, which successfully classified TNBC cases into high- and low-risk groups and showed predictive power in multiple datasets. This novel signature provides a better understanding of genome instability in TNBC and can serve as prognostic markers for clinical TNBC management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland, Michael C. Campbell, Luciane R. Cavalli, Yasmine Kanaan
Summary: This study identified specific miRNAs associated with tumor size, LN, and REC status in AA TNBC patients with high discriminatory power. These miRNAs are involved in proteglycans, glycan, and cancer-associated pathways, and are significantly associated with lower survival rates.
Article
Oncology
Michal Marczyk, Tao Qing, Tess O'Meara, Vesal Yagahoobi, Vasiliki Pelekanou, Yalai Bai, Emily Reisenbichler, Kimberly S. Cole, Xiaotong Li, Vignesh Gunasekharan, Eiman Ibrahim, Kristina Fanucci, Wei Wei, David L. Rimm, Lajos Pusztai, Kim R. M. Blenman
Summary: Differences in the tumor immune microenvironment may exist between African American and NonAA breast cancer patients, which may impact treatment response and prognosis.
Article
Oncology
B. B. M. Suelmann, A. Rademaker, C. van Dooijeweert, E. van der Wall, P. J. van Diest, C. B. Moelans
Summary: This study provides insights into the genomic background of triple-negative breast cancer during pregnancy and identifies CNAs that are associated with prognosis. FGFR1 loss and TOP2A loss may serve as biomarkers for poor prognosis and provide clues for personalized therapy.
Article
Oncology
Masayuki Nagahashi, YiWei Ling, Chie Toshikawa, Tetsu Hayashida, Yuko Kitagawa, Manabu Futamura, Takashi Kuwayama, Seigo Nakamura, Hideko Yamauchi, Teruo Yamauchi, Koji Kaneko, Chizuko Kanbayashi, Nobuaki Sato, Junko Tsuchida, Kazuki Moro, Masato Nakajima, Yoshifumi Shimada, Hiroshi Ichikawa, Stephen Lyle, Yasuo Miyoshi, Kazuaki Takabe, Shujiro Okuda, Toshifumi Wakai
Summary: This study aimed to clarify the clinical significance of genomic profiling data, including copy number alterations (CNA) and tumor mutation burden (TMB), in TNBC patients. The results showed that CNA, but not TMB, was significantly associated with DFS and OS in TNBC patients. Additionally, the combination of CNA-high and TP53 alterations was identified as a promising biomarker for identifying a subgroup of TNBC patients with significantly worse prognosis.
Article
Oncology
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Summary: This study compared the differences in PTEN expression between pre- and post-treatment tumors in patients with triple-negative breast cancer (TNBC). It also explored the possibility of using next-generation sequencing (NGS) as an alternative to immunohistochemistry (IHC) to identify PTEN loss. The results showed that testing different specimens by IHC may generate different PTEN results in a small proportion of TNBC patients.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Tania Rossi, Michela Palleschi, Davide Angeli, Michela Tebaldi, Giovanni Martinelli, Ivan Vannini, Maurizio Puccetti, Francesco Limarzi, Roberta Maltoni, Giulia Gallerani, Francesco Fabbri
Summary: This study focused on analyzing circulating tumor cells from a patient with triple-negative spindle-shaped metaplastic breast cancer, showing the important role of CTCs in the metastatic process. Despite the high heterogeneity of CTCs in morphology, their amplification regions are related to metastasis. This research provides a new direction for identifying alterations that play a role in the metastatic process.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Getinet M. Adinew, Equar Taka, Patricia Mendonca, Samia S. Messeha, Karam F. A. Soliman
Summary: Flavonoids, as new promising molecules, show various biological activities and can modulate miRNAs to affect the progression of TNBC, emphasizing their potential role in the prevention and treatment of TNBC.
Article
Oncology
P. Travis Courtney, Rishi Deka, Nikhil Kotha, Daniel R. Cherry, Mia A. Salans, Tyler J. Nelson, Abhishek Kumar, Elaine Luterstein, Anthony T. Yip, Vinit Nalawade, J. Kellogg Parsons, A. Karim Kader, Tyler F. Stewart, Brent S. Rose
Summary: Outcomes were similar for African American and White men treated for low-intermediate-risk prostate cancer with active surveillance in the Veterans Affairs Health System.
Article
Genetics & Heredity
Megan Phillips, Vaithinathan Selvaraju, Anna Fouty, Jeganathan Ramesh Babu, Maninder Sandey, Thangiah Geetha
Summary: The study found that the copy number of the 11q11 gene was significantly higher in girls compared to boys, and AA participants had more copies than EA participants. Both normal weight and overweight/obese girls were less likely to belong to the low copy number variant group of 11q11 compared to boys, and a similar trend was observed in AA children.
Article
Cell Biology
Yue Gong, Peng Ji, Yun-Song Yang, Shao Xie, Tian-Jian Yu, Yi Xiao, Ming-Liang Jin, Ding Ma, Lin-Wei Guo, Yu-Chen Pei, Wen-Jun Chai, Da-Qiang Li, Fan Bai, Francois Bertucci, Xin Hu, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: This study investigated metabolic dysregulation in TNBCs using a multi-omics database, identifying three heterogeneous metabolic-pathway-based subtypes with distinct metabolic features. These subtypes had different prognoses, molecular subtype distributions, and genomic alterations, as well as varying sensitivities to metabolic inhibitors targeting fatty acid synthesis and glycolysis. Additionally, inhibition of lactate dehydrogenase could enhance tumor response to anti-PD-1 immunotherapy in specific TNBC subtypes.
Article
Biochemistry & Molecular Biology
Riccardo Panella, Cody A. Cotton, Valerie A. Maymi, Sachem Best, Kelsey E. Berry, Samuel Lee, Felipe Batalini, Ioannis S. Vlachos, John G. Clohessy, Sakari Kauppinen, Pier Paolo Pandolfi
Summary: In this study, it was found that miR-22, an oncogenic miRNA, is up-regulated in hormone-responsive breast cancer and promotes EMT, tumor invasion, and metastasis. In triple negative breast cancer (TNBC), miR-22 plays a key role in promoting EMT and aggressiveness. Inhibition of miR-22 using an LNA-modified compound effectively reduces EMT both in vitro and in vivo, providing a potential therapeutic strategy for TNBC treatment.
Article
Oncology
Mansoor Saleh, Darshan Shimoga Chandrashekar, Sayed Shahin, Sumit Agarwal, Hyung-Gyoon Kim, Michael Behring, Asim Jamal Shaikh, Zahir Moloo, Isam-Eldin A. Eltoum, Clayton Yates, Sooryanarayana Varambally, Upender Manne
Summary: This study aimed to identify transcriptome differences in TNBC patients of Bantu origin from Kenya compared to African-American and Caucasian TNBC patients. Analysis revealed 45 KE TNBC-specific genes associated with pathways such as apoptosis, cell proliferation, and Wnt signaling. These findings suggest potential molecular determinants and biomarkers specific to KE TNBC patients.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Bruna M. Sugita, Yara Rodriguez, Aline S. Fonseca, Emanuelle Nunes Souza, Bhaskar Kallakury, Iglenir J. Cavalli, Enilze M. S. F. Ribeiro, Ritu Aneja, Luciane R. Cavalli
Summary: MiR-150-5p is highly expressed in triple-negative breast cancer (TNBC) and its expression levels are associated with tumor grade, patient survival, and ethnicity. Overexpression of miR-150-5p contributes to the aggressive phenotypes of TNBC cells.
Article
Biochemistry & Molecular Biology
Patricia A. Da Cunha, Diana Nitusca, Luisa Matos Do Canto, Rency S. Varghese, Habtom W. Ressom, Shawna Willey, Catalin Marian, Bassem R. Haddad
Summary: Breast cancer is a leading cause of cancer-related deaths in women worldwide, and there is a need for new biomarkers for early detection. This study used metabolomic profiling to identify specific metabolic markers for breast cancer and developed a highly effective diagnostic model.
Article
Medicine, Research & Experimental
Simona Maria Borta, Imola Donath-Miklos, Romana Popetiu, Dragos Vasile Nica, Diana Nitusca, Adrian Crisan, Catalin Marian, Maria Puschita
Summary: This study aimed to analyze the associations between different MBL2 genotypes and susceptibility to bronchial asthma in Romanian children, as well as the correlations between several patient sociodemographic variables and MBL2 polymorphisms. The results showed no statistically significant associations between MBL2 polymorphisms and susceptibility to bronchial asthma. Weak positive correlations were found between age at diagnosis and A/B genotype, and between the smoking status of biologically male and female parents. A weak inverse association was found between male parent smoking status and family history of asthma. These findings provide insights for future research and treatment of pediatric bronchial asthma.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Oncology
Vanessa G. P. Souza, Rachel Paes de Araujo, Mariana R. Santesso, Ana Laura Seneda, Iael W. Minutentag, Tainara Francini Felix, Pedro Tadao Hamamoto, Michelle E. Pewarchuk, Liam J. Brockley, Fabio A. Marchi, Wan L. Lam, Sandra A. Drigo, Patricia P. Reis
Summary: Patients with lung cancer frequently develop brain metastasis (BM), resulting in poor prognosis. Although genetic alterations associated with the spread of lung cancer cells have been identified, the exact mechanisms of BM remain unclear. This review comprehensively describes the steps of metastatic spread to the brain and explores the influence of tumor microenvironment and molecular determinants of progression. It also highlights the advancements in liquid biopsy-based molecular diagnostics and discusses novel treatment strategies.
Article
Oncology
Benson Chellakkan Selvanesan, Alvaro de Mingo Pulido, Sheelu Varghese, Deepak Rohila, Daniel Hupalo, Yuriy Gusev, Sara Contente, Matthew D. Wilkerson, Clifton L. Dalgard, Geeta Upadhyay
Summary: This study investigated the effect of a small molecule NSC243928 on intra-tumoral immune cells in mouse mammary tumor models. NSC243928 treatment reduced tumor burden and altered immune cell infiltration. The study suggests that NSC243928 could be a potential drug for immuno-oncology and breast cancer treatment.
Article
Multidisciplinary Sciences
Alexandra Ioana Moatar, Aimee Rodica Chis, Mirabela Romanescu, Paula-Diana Ciordas, Diana Nitusca, Catalin Marian, Cristian Oancea, Ioan-Ovidiu Sirbu
Summary: This study evaluated the early level of circulating miR-195 in Covid-19 patients and found it to be a potential biomarker of disease severity. miR-195 is associated with several clinical and paraclinical parameters and can effectively discriminate between severe and mild forms of the disease. The study also suggests a possible role of miR-195 in long Covid and chronic fatigue syndrome.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Ana-Maria Marin, Dan-Cornel Popovici, Gheorghe Darabus, Catalin Marian, Diana Nitusca, Narcisa Mederle
Summary: This study confirms the presence of Trichinella britovi in raccoon dogs for the first time by detecting the parasite larvae in muscle samples from Romania.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Maria Sala-Cirtog, Laurentiu Sima, Andrei Anghel, Catalin Marian, Aimee Rodica Chis, Ioan-Ovidiu Sirbu
Summary: Left ventricle remodeling after acute myocardial infarction is a significant contributor to heart failure, but predicting it remains challenging. This study found that certain circulant microRNAs may not be effective in distinguishing patients with left ventricle remodeling from those without.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Aimee Rodica Chis, Catalin Marian, Constantin Tudor Luca, Ioan-Ovidiu Sirbu, Dan Gaita
Summary: Left ventricle remodeling after acute myocardial infarction leads to heart failure, but predicting this remodeling is challenging. This study found that the microRNA miR-22 can accurately distinguish between patients with and without left ventricle remodeling. The predictive power of miR-22 is even better when combined with other clinical variables. miR-22 may be a useful predictor of ventricular function recovery in STEMI patients.
Article
Health Care Sciences & Services
Simona-Alina Abu-Awwad, Marius Craina, Lioara Boscu, Elena Bernad, Paula Diana Ciordas, Catalin Marian, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Brenda Bernad, Diana Maria Anastasiu Popov, Anca Laura Maghiari
Summary: This research investigates the association between altered lipid profiles and hypertensive disorders of pregnancy (HDP). The study finds significant elevations in Apolipoprotein B (ApoB) and Lipoprotein(a) (Lp(a)) levels in pregnant women with HDP, emphasizing the importance of early detection and specialized handling of cardiovascular risks in expectant mothers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Simona-Alina Abu-Awwad, Marius Craina, Lioara Boscu, Elena Bernad, Paula Diana Ciordas, Catalin Marian, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Brenda Bernad, Diana Maria Anastasiu Popov, Anca Laura Maghiari
Summary: This study compares the lipid profiles of pregnant women with and without cardiovascular risk factors, revealing that women with cardiovascular risk factors have higher rates of adverse neonatal outcomes and abnormal lipid and inflammatory profiles. These findings highlight the need for effective risk stratification and management strategies in this population.
Article
Biochemistry & Molecular Biology
Diana Nitusca, Carmen Socaciu, Andreea Iulia Socaciu, Ioan Ovidiu Sirbu, Razvan Bardan, Alin Adrian Cumpanas, Edward Seclaman, Catalin Marian
Summary: Prostate cancer is a leading cause of cancer mortality in men worldwide, with a lack of specific early detection and staging biomarkers. This study identified five potential biomarkers for prostate cancer using metabolomics, with all the molecules displaying decreased levels in prostate cancer plasma samples. The high diagnostic accuracy of these metabolites suggests their potential as non-invasive biomarkers for prostate cancer detection.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Simona-Alina Abu-Awwad, Marius Craina, Adrian Gluhovschi, Paula Diana Ciordas, Catalin Marian, Lioara Boscu, Elena Bernad, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Anca Laura Maghiari
Summary: This study investigated whether pregnant women with cardiovascular risk have shorter telomeres compared to those without cardiovascular risk. The results showed that pregnant women with cardiovascular risk had significantly shorter telomeres, which may have implications for the long-term health of both the mother and the child.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ionut Dragos Capraru, Dan Dumitru Vulcanescu, Iulia Cristina Bagiu, Florin George Horhat, Irina Maria Popescu, Luminita Mirela Baditoiu, Delia Muntean, Monica Licker, Matilda Radulescu, Ion Cristian Mot, Mircea Mihai Diaconu, Catalin Marian
Summary: This study aimed to investigate the associations between biomarkers CRP, LDH, CK, 25-OHD, ferritin, HDL cholesterol, and clinical severity in COVID-19 patients in Romania, and their potential use in predicting ICU admission and death. The results showed that CRP, LDH, 25-OHD, ferritin, and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
MEDICINA-LITHUANIA
(2023)
Article
Pharmacology & Pharmacy
Iosif Ilia, Doina Chioran, Daniela Radu, Raul Chioiba, Ioana Ionita, Catalin Marian, Alexandra Semenescu, Robert Cosmin Racea, Ramona Popovici, Stefania Dinu, Mircea Rivis, Andrada Iftode
Summary: Hyaluronic acid has the potential to be an effective candidate for the treatment of osteosarcoma, as it can induce cell apoptosis and alter gene expression. However, further research is needed to elucidate the molecular mechanisms involved.