Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets
Authors
Keywords
triple-negative breast cancer, metabolism, heterogeneity, metabolic pathway, subtype, glycolysis, metabolic inhibitor, immunotherapy, survival
Journal
Cell Metabolism
Volume 33, Issue 1, Pages 51-64.e9
Publisher
Elsevier BV
Online
2020-11-12
DOI
10.1016/j.cmet.2020.10.012
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The prognostic value of the tumor–stroma ratio is most discriminative in patients with grade III or triple‐negative breast cancer
- (2020) Kiki M.H. Vangangelt et al. INTERNATIONAL JOURNAL OF CANCER
- Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma
- (2019) Saeed Daneshmandi et al. Cancers
- Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment
- (2019) Ana C. Garrido-Castro et al. Cancer Discovery
- Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies
- (2019) Yi-Zhou Jiang et al. CANCER CELL
- Next-generation characterization of the Cancer Cell Line Encyclopedia
- (2019) Mahmoud Ghandi et al. NATURE
- The landscape of cancer cell line metabolism
- (2019) Haoxin Li et al. NATURE MEDICINE
- Targeting metabolism to regulate immune responses in autoimmunity and cancer
- (2019) Chirag H. Patel et al. NATURE REVIEWS DRUG DISCOVERY
- Breast cancer quantitative proteome and proteogenomic landscape
- (2019) Henrik J. Johansson et al. Nature Communications
- Mechanisms and Implications of Metabolic Heterogeneity in Cancer
- (2019) Jiyeon Kim et al. Cell Metabolism
- Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
- (2019) Georgina V Long et al. LANCET ONCOLOGY
- Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial
- (2019) Peter Schmid et al. LANCET ONCOLOGY
- Reprogramming of fatty acid metabolism in cancer
- (2019) Nikos Koundouros et al. BRITISH JOURNAL OF CANCER
- Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis
- (2018) Y Bareche et al. ANNALS OF ONCOLOGY
- Oncogenic Signaling Pathways in The Cancer Genome Atlas
- (2018) Francisco Sanchez-Vega et al. CELL
- Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
- (2018) Anneleen Daemen et al. Cell Metabolism
- MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
- (2018) Jasmine Chong et al. NUCLEIC ACIDS RESEARCH
- Personalized Cancer Medicine: An Organoid Approach
- (2018) Hamidreza Aboulkheyr Es et al. TRENDS IN BIOTECHNOLOGY
- A Landscape of Metabolic Variation across Tumor Types
- (2018) Ed Reznik et al. Cell Systems
- PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers
- (2018) Géraldine Gentric et al. Cell Metabolism
- Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
- (2018) Peter Schmid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas
- (2018) S. R. Rosario et al. Nature Communications
- The tumor-stromal ratio as a strong prognosticator for advanced gastric cancer patients: proposal of a new TSNM staging system
- (2017) Chunwei Peng et al. JOURNAL OF GASTROENTEROLOGY
- Molecular alterations in triple-negative breast cancer—the road to new treatment strategies
- (2017) Carsten Denkert et al. LANCET
- Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
- (2017) Nicholas A Graham et al. Molecular Systems Biology
- FOXM1 regulates glycolysis in hepatocellular carcinoma by transactivating glucose transporter 1 expression
- (2017) Runze Shang et al. ONCOLOGY REPORTS
- Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line
- (2017) Chung-Ho E. Lau et al. Scientific Reports
- An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
- (2016) A. Ari Hakimi et al. CANCER CELL
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
- (2016) Giampaolo Bianchini et al. Nature Reviews Clinical Oncology
- Cancer metabolism: a therapeutic perspective
- (2016) Ubaldo E. Martinez-Outschoorn et al. Nature Reviews Clinical Oncology
- Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
- (2016) Edoardo Gaude et al. Nature Communications
- Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection
- (2016) Brian D. Lehmann et al. PLoS One
- Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer
- (2015) Deena M. A. Gendoo et al. BIOINFORMATICS
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
- (2015) Hideki Makinoshima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MYC, Metabolism, and Cancer
- (2015) Z. E. Stine et al. Cancer Discovery
- Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
- (2014) M. D. Burstein et al. CLINICAL CANCER RESEARCH
- FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
- (2014) J. Cui et al. CLINICAL CANCER RESEARCH
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
- (2013) Atsushi Terunuma et al. JOURNAL OF CLINICAL INVESTIGATION
- Heterogeneity of tumor-induced gene expression changes in the human metabolic network
- (2013) Jie Hu et al. NATURE BIOTECHNOLOGY
- Tumour-associated mutant p53 drives the Warburg effect
- (2013) Cen Zhang et al. Nature Communications
- The sva package for removing batch effects and other unwanted variation in high-throughput experiments
- (2012) Jeffrey T. Leek et al. BIOINFORMATICS
- Targeting glucose metabolism for cancer therapy: Figure 1.
- (2012) Robert B. Hamanaka et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- (2012) Christina Curtis et al. NATURE
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
- (2011) Brian D. Lehmann et al. JOURNAL OF CLINICAL INVESTIGATION
- ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
- (2010) Matthew D. Wilkerson et al. BIOINFORMATICS
- Triple-Negative Breast Cancer
- (2010) William D. Foulkes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Allele-specific copy number analysis of tumors
- (2010) P. Van Loo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identifying Tightly Regulated and Variably Expressed Networks by Differential Rank Conservation (DIRAC)
- (2010) James A. Eddy et al. PLoS Computational Biology
- Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
- (2009) Joel S. Parker et al. JOURNAL OF CLINICAL ONCOLOGY
- Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer
- (2008) James J. Dignam et al. BREAST CANCER RESEARCH AND TREATMENT
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started