Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Cell Biology
Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu, Yuling Li
Summary: Cancer-secreted exosomes containing miR-21-5p play a crucial role in promoting angiogenesis and vascular permeability in colorectal cancer by suppressing KRIT1 and activating the beta-catenin signaling pathway. The expression levels of miR-21-5p in circulating exosomes are significantly higher in CRC patients compared to healthy donors, suggesting its potential as a therapeutic target for CRC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zixu Bao, Ning Zhang, Wanxiang Niu, Maolin Mu, Xiaoming Zhang, Shanshan Hu, Chaoshi Niu
Summary: Exosomes released from glioma stem-like cells (GSCs) containing miR-155-5p can be horizontally transferred to surrounding glioma cells, promoting tumor progression and mesenchymal transition by targeting ACOT12. High expression of miR-155-5p in plasma exosomes is associated with glioma diagnosis and grading, suggesting its potential as a predictive biomarker for glioma.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Ling Zuo, Yi Zhu, Jinli Han, Hongwei Liu
Summary: This article demonstrates that circSHPRH is downregulated in bladder cancer tissues and is associated with high grade, high pathological stage, lymphatic metastasis, and poor prognosis. Silencing circSHPRH promotes proliferation, migration, and invasion of bladder cancer cells, while overexpression suppresses tumor growth. Mechanistic studies reveal that circSHPRH acts as a sponge of miR-942, targeting BARX2. Suppression of miR-942 or overexpression of BARX2 counteracts the promoting effects of circSHPRH silencing on bladder cancer cell proliferation and invasion. Additionally, circSHPRH overexpression partially eliminates the inhibitory effects of miR-942 on BARX2 expression and activates the Wnt/β-catenin signaling pathway by regulating BARX2.
Article
Oncology
Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Guodong Liu
Summary: The study revealed that androgen receptor can suppress HCC cells invasion and migration capacities via miR-122-5p/RABL6 signaling, providing a new potential therapeutic target for better treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Shaojian Lin, Yue Zhu, Chengcheng Ji, Weiming Yu, Cheng Zhang, Langping Tan, Miaoyun Long, Dingyuan Luo, Xinzhi Peng
Summary: This study suggests that the overexpression of METTL3 is associated with malignant behaviors in thyroid carcinoma (TC), and it promotes tumor development and metastasis by regulating the expression levels of miR-222-3p and STK4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Wansong Lin, Jie Lin, Jieyu Li, Ying Lin, Shuping Chen, Yijuan Wu, Lingfeng Chen, Hui Cheng, Lin Liu, Xiaoyan Chen, Yunbin Ye
Summary: This study reveals that Kindlin-2 regulates HCC cell migration and metastasis through the suppression of miR-1258 and the upregulation of TCF4 expression. It also identifies a positive feedback loop between Kindlin-2, miR-1258, and TCF4. These findings provide important evidence for the potential therapeutic targeting of Kindlin-2 in HCC.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Sun, J. Wang, J. Liu, F. Yin, C. Xin, X. Zeng, J. Li, Q. Chen
Summary: Oral squamous cell carcinoma (OSCC) has a high rate of metastasis and poor prognosis, with tobacco and/or alcohol consumption and human papillomavirus infection as susceptibility factors. miR-302b has been found to inhibit the invasion and migration ability of OSCC cells by targeting and downregulating FZD6. This suggests that miR-302b and FZD6 could serve as potential prognostic and therapeutic targets for OSCC patients.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Zhen-Jie Li, Jin-Ping Zhang, Dong-Ying Li, Hui-Yu Yang, Bing-Rong Liu
Summary: The study reveals that ATF2 promotes cell proliferation, migration, invasion and metastasis in HCC by regulating the miR-548p/TUFT1 axis. This finding provides new insights into the pathogenesis of HCC and the development of novel medications.
HEPATOLOGY RESEARCH
(2022)
Article
Biochemical Research Methods
Vahid Asghariazar, Mahtab Kadkhodayi, Behzad Mansoori, Ali Mohammadi, Behzad Baradaran
Summary: This study indicates that upregulation of miR-143 in bladder cancer cells inhibits cell proliferation and migration, and is negatively associated with the expression of metastatic, apoptotic, and EMT-related genes. Therefore, miR-143 may be considered as a potential therapeutic target for bladder cancer.
MOLECULAR AND CELLULAR PROBES
(2022)
Article
Gastroenterology & Hepatology
Bin Sun, Weidan Ji, Chunying Liu, Xuejing Lin, Lei Chen, Haihua Qian, Changqing Su
Summary: miR-2392 is significantly down-regulated in HCC and functions as a tumor suppressor by targeting JAG2 to inhibit proliferation, clonogenicity, mobility, spheroid formation, and maintenance of CSC-like characteristics in HCC cells. CTCs from HCC patients with lower serum miR-2392 levels exhibit stronger spheroid formation ability, and a negative correlation between miR-2392 levels in serum and the number of CTC spheroids has been observed. JAG2 is highly expressed in HCC and is associated with poor prognosis and patient survival.
LIVER INTERNATIONAL
(2022)
Article
Cell Biology
Jie Wang, Zhiwei He, Jian Xu, Peng Chen, Jianxin Jiang
Summary: The study found that LINC00941 acts as an oncogene in the progression of pancreatic cancer, functioning as a ceRNA for miR-335-5p. High expression of LINC00941 was associated with tumor size, lymph node metastasis, and poor prognosis, and its silencing significantly inhibited cell growth and metastasis in PC.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yoshihisa Tokumaru, Masanori Oshi, Michelle R. Huyser, Li Yan, Masahiro Fukada, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Summary: The study found that low expression of miR-29a is associated with aggressive cancer biology and worse survival in gastric cancer patients, serving as an independent prognostic biomarker of poor overall survival and disease-specific survival.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Arpita Ghosh, Nihar Ranjan, Liuwei Jiang, Asgar Hussain Ansari, Natalya Degyatoreva, Shivaksh Ahluwalia, Dev P. Arya, Souvik Maiti
Summary: MicroRNAs (miRs) are endogenously expressed non-coding RNAs that regulate gene expression within cells and are involved in maintaining cellular homeostasis. Aberrantly expressed miRs can be associated with diseases such as cancer. miR-21, highly expressed in breast cancer cells, acts as an onco-miR by targeting PTEN protein and promoting epithelial to mesenchymal transition (EMT). This study uses peptidic amino sugar molecules to target pre-miR-21 and inhibit its biogenesis, thereby counteracting its tumor-causing effect and inhibiting EMT.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang
Summary: This study investigated a circular RNA called circROCK1-E3/E4 in osteosarcoma (OS) and found that it functions as a tumor suppressor by upregulating PTEN. The downregulation of circROCK1-E3/E4 is correlated with poor prognosis, suggesting its potential as a therapeutic target for OS.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)