Article
Biochemical Research Methods
Chen Yang, Xiaowen Huang, Yan Li, Junfei Chen, Yuanyuan Lv, Shixue Dai
Summary: This study retrospectively analyzed 1135 HCC patients and developed a random forest-based prediction model to estimate TP53 mutational status, as well as a robust poor prognosis-associated signature which showed superior ability to predict survival in TP53-mutant patients. In silico screening revealed three targets and two agents that might have potential therapeutic implications in high-PPS patients, presenting a comprehensive view of potential treatment strategy.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Kazuma Kiyotani, Yujiro Toyoshima, Yusuke Nakamura
Summary: The significant advances in cancer genomics have allowed for precision medicine based on genomic and molecular profiling, but clinical application still faces challenges. Cancer immunotherapies, particularly targeting neoantigens derived from somatic mutations, offer potential for precise treatment based on genomic sequencing results.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Oncology
Karin P. S. Langenberg, Eleonora J. Looze, Jan J. Molenaar
Summary: Precision medicine is a revolutionary approach to cancer treatment that targets specific genetic changes in individual patients to improve cure rates and reduce toxicity. The characteristics and early results of precision medicine programs in pediatric oncology show potential clinical benefits. Future perspectives include incorporating novel approaches and collaborative trial designs to target aberrations in childhood malignancies.
Review
Oncology
Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Joern Walter, Mehdi Totonchi
Summary: Colorectal cancer, the second leading cause of cancer death worldwide, is closely associated with epigenetic changes such as DNA methylation. Studies have shown that DNA methylation markers have high accuracy and reproducibility in noninvasive biosamples, making them promising for early diagnosis and personalized treatment of CRC. Further research and development of methylation biomarkers and detection methods are crucial for CRC diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Health Care Sciences & Services
Umile Giuseppe Longo, Arianna Carnevale, Carlo Massaroni, Daniela Lo Presti, Alessandra Berton, Vincenzo Candela, Emiliano Schena, Vincenzo Denaro
Summary: The study proposes a personalized, predictive, participatory, precision, and preventive (P5) medicine model, highlighting the potential for tailoring diagnosis and therapy for patients with RC diseases by defining genetic predispositions and assessing lifestyle and environmental factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Chao Mei, Weijing Gong, Xu Wang, Yongning Lv, Yu Zhang, Sanlan Wu, Chunqi Zhu
Summary: Ovarian cancer is the most fatal disease among gynecologic malignant tumors. Tumor angiogenesis, regulated by multiple factors and pathways, plays a vital role in the development and progression of cancer. However, the efficacy of anti-angiogenic therapy is limited by low response rates and emerging drug resistance. This review focuses on the mechanisms, clinical trial outcomes, resistance mechanisms, biomarkers, and predictive models of anti-angiogenic therapy in ovarian cancer, providing insights into the prospect of precision medicine.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Eva Ceskova, Petr Silhan
Summary: Personalised medicine aims to provide individualized treatment for each patient, using quantifiable indicators to make decisions. Precision psychiatry is in its early stages, utilizing artificial intelligence and machine learning to gather and analyze sufficient data for diagnosis assessment and treatment planning.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Hematology
Colleen A. Ramsower, Allison Rosenthal, Ryan S. Robetorye, Raphael Mwangi, Matthew Maurer, Diego Villa, Tim McDonnell, Andrew Feldman, Jonathon B. Cohen, Thomas Habermann, Elias Campo, Guillem Clot, Marco M. Buhler, Marta Kulis, Jose Ignacio Martin-Subero, Eva Gine, James R. Cook, Brian Hill, Philipp W. Raess, Klaus H. Beiske, Alexander Reichart, Sylvia Hartmann, Harald Holte, David Scott, Lisa Rimsza
Summary: In this study, a comprehensive comparison of clinicopathological features in older mantle cell lymphoma (MCL) patients was undertaken. The strongest prognostic indicators were identified as the simplified MCL international prognostic index (s-MIPI) and MCL35, along with blastoid cytology. Combining MIPI with MCL35 to assess proliferation may be an effective method for risk stratification in older MCL patients in future clinical trials.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Hematology
David Qualls, Anita Kumar
Summary: The diverse presentations and treatment options in MCL highlight the need for a personalized therapeutic approach.
EXPERT REVIEW OF HEMATOLOGY
(2023)
Review
Genetics & Heredity
Elena Fountzilas, Apostolia M. Tsimberidou, Henry Hiep Vo, Razelle Kurzrock
Summary: Recent breakthroughs in biotechnology have allowed for the identification of unique molecular features that drive malignancies. Precision medicine has used next-generation sequencing and matched targeted therapy/immunotherapy to transform the outlook for fatal cancers. Multiple trial designs and personalized combination treatment strategies have been implemented to accelerate drug evaluation and individualized treatment.
Review
Health Care Sciences & Services
Danijel Galun, Dragana Mijac, Aleksandar Filipovic, Aleksandar Bogdanovic, Marko Zivanovic, Dragan Masulovic
Summary: Hepatocellular carcinoma (HCC) is a major malignant disease worldwide. Despite advancements in surveillance, diagnosis, and treatment, the incidence and mortality rates remain high. Liver cirrhosis is a common risk factor for HCC, and the risks from both the tumor and cirrhosis should be considered. Precision medicine challenges the traditional approach by tailoring treatment based on individual molecular targets. Next-generation sequencing and genetic markers offer potential for better understanding HCC heterogeneity and identifying vulnerabilities. A shift towards a therapeutic-oriented approach is needed for personalized HCC treatment. Multidisciplinary approval is crucial for decision-making in precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cell Biology
Elisa Tirtei, Anna Campello, Sebastian D. Asaftei, Katia Mareschi, Matteo Cereda, Franca Fagioli
Summary: Osteosarcoma is a rare bone malignant tumor with a poor prognosis, and there is no consensus on the best systemic therapy for relapsed cases. The availability of next generation sequencing techniques has revolutionized clinical research, but the development of precision medicine for relapsed OS still faces challenges.
Review
Biochemistry & Molecular Biology
Dannel Yeo, Althea Bastian, Heidi Strauss, Payal Saxena, Peter Grimison, John E. J. Rasko
Summary: This review summarizes the data on the utility of CTCs in PDAC and discusses the molecular profiling and culture methods of CTCs. CTCs have the potential to be used in screening, early diagnosis, prognostic assessment, and personalized management of PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Edoardo Crimini, Matteo Repetto, Philippe Aftimos, Andrea Botticelli, Paolo Marchetti, Giuseppe Curigliano
Summary: This review presents the most important molecular targets in breast cancer, classified according to their pathway and in accordance with ESCAT, assisting clinicians in making therapeutic decisions.
CANCER TREATMENT REVIEWS
(2021)
Article
Biology
Samart Jamrat, Chonlaphat Sukasem, Lawan Sratthaphut, Yaowaluck Hongkaew, Taweesak Samanchuen
Summary: This study proposes an approach towards precision medicine that combines genetic and nongenetic factors to facilitate clinical decision-making. The approach focuses on improving the performance of potential interaction screenings in the prescribing process and provides a personalized prescribing report. Three case studies have demonstrated the concept and effectiveness of this approach. It offers a promising solution to implementing precision medicine in clinical practice.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Hematology
Alex F. Herrera, Andre Goy, Amitkumar Mehta, Radhakrishnan Ramchandren, John M. Pagel, Jakub Svoboda, Shanhong Guan, John S. Hill, Kevin Kwei, Emily A. Liu, Tycel Phillips
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Article
Oncology
Lucia Oton-Gonzalez, John Charles Rotondo, Luca Cerritelli, Nicola Malagutti, Carmen Lanzillotti, Ilaria Bononi, Andrea Ciorba, Chiara Bianchini, Chiara Mazziotta, Monica De Mattei, Stefano Pelucchi, Mauro Tognon, Fernanda Martini
Summary: A fraction of KP samples tested positive for oncogenic HPV16, suggesting a potential association between HPV16 and KP. Detection of HPV16 in the antral portion of KP may be derived from the maxillary sinus. HPV16 DNA integration represents a novel finding, indicating heterogeneity in the onset of KP.
INFECTIOUS AGENTS AND CANCER
(2021)
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yekatsiaryna Hushcha, Irene Blo, Lucia Oton-Gonzalez, Giulia Di Mauro, Fernanda Martini, Mauro Tognon, Monica De Mattei
Summary: Melanogenesis is a complex biological process regulated by internal and external factors, as well as epigenetic factors such as miRNAs, which ultimately affect melanin synthesis by regulating key factors such as MITF. Understanding the role of miRNAs in melanogenesis can provide insights into the regulation mechanism of this biological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Andre Goy
Summary: Treatment outcomes for MCL have improved, but high-risk patients still face poor prognosis. Studies indicate that high-risk molecular features are driving a new treatment paradigm, with advancements in novel therapies and diagnostics potentially enhancing outcomes for MCL patients.
EXPERT REVIEW OF HEMATOLOGY
(2021)
Article
Immunology
Chiara Mazziotta, Carmen Lanzillotti, Elena Torreggiani, Lucia Oton-Gonzalez, Maria Rosa Iaquinta, Elisa Mazzoni, Pauline Gaboriaud, Antoine Touze, Ettore Silvagni, Marcello Govoni, Fernanda Martini, Mauro Tognon, John Charles Rotondo
Summary: The study utilized a novel indirect ELISA method using two synthetic peptides to analyze antibodies against MCPyV. Results showed high sensitivity, specificity, and accuracy in detecting IgGs against MCPyV VP mimotopes, indicating a relatively high prevalence of MCPyV infection among the population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lucia Oton-Gonzalez, John Charles Rotondo, Carmen Lanzillotti, Elisa Mazzoni, Ilaria Bononi, Maria Rosa Iaquinta, Luca Cerritelli, Nicola Malagutti, Andrea Ciorba, Chiara Bianchini, Stefano Pelucchi, Mauro Tognon, Fernanda Martini
Summary: Classical markers alone may not be enough to classify HPV-positive HNSCC patients, but when combined with serological markers, they are strong prognostic indicators in OPSCC patients. Detection of HPV16 E7 oncoprotein in serum at diagnosis is correlated with disease recurrence and patient overall survival, providing a useful tool for stratifying and monitoring HPV-positive HNSCC patients for worse prognosis.
Review
Biochemistry & Molecular Biology
Lucia Oton-Gonzalez, Chiara Mazziotta, Maria Rosa Iaquinta, Elisa Mazzoni, Riccardo Nocini, Lorenzo Trevisiol, Antonio D'Agostino, Mauro Tognon, John Charles Rotondo, Fernanda Martini
Summary: This article summarizes the genetics and epigenetics of the bone remodeling process, as well as current research findings on the genetics of metabolic bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maher Albitar, Hong Zhang, Andre Goy, Zijun Y. Xu-Monette, Govind Bhagat, Carlo Visco, Alexandar Tzankov, Xiaosheng Fang, Feng Zhu, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andres J. M. Ferreri, Michael B. Moller, Benjamin M. Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Bing Xu, Ken H. Young
Summary: Multiple studies have shown that DLBCL can be divided into distinct subgroups based on biology, but these subgroups often overlap clinically. In this study, a machine learning approach was used to stratify DLBCL patients into four survival subgroups based on gene expression data. The model accurately predicted the subgroups and their prognosis, and it was validated using independent patient groups. This stratification strategy can help identify patients who may not respond well to standard therapy and could benefit from alternative treatments or clinical trials.
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Michael Wang, Javier Munoz, Andre Goy, Frederick L. Locke, Caron A. Jacobson, Brian T. Hill, John M. Timmerman, Houston Holmes, Samantha Jaglowski, Ian W. Flinn, Peter A. McSweeney, David B. Miklos, John M. Pagel, Marie Jose Kersten, Krimo Bouabdallah, Rashmi Khanal, Max S. Topp, Roch Houot, Amer Beitinjaneh, Weimin Peng, Xiang Fang, Rhine R. Shen, Rubina Siddiqi, Ioana Kloos, Patrick M. Reagan
Summary: Brexucabtagene autoleucel (KTE-X19) autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown durable long-term responses with manageable safety in patients with relapsed/refractory mantle cell lymphoma (MCL) and may benefit those with high-risk characteristics.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Hematology
Michael R. Cook, C. Scott Dorris, Kepher H. Makambi, Yutong Luo, Pashna N. Munshi, Michelle Donato, Scott Rowley, Ayman Saad, Andre Goy, Kieron Dunleavy, Alaa Ali
Summary: Relapsed/refractory primary central nervous system lymphoma (PCNSL) and secondary central nervous system lymphoma (SCNSL) have limited treatment options and poor prognosis. This study conducted a systematic review and meta-analysis of CAR T-cell therapy in PCNSL and SCNSL. The results showed that CAR T-cell therapy had acceptable toxicity and promising efficacy in both PCNSL and SCNSL patients.
Article
Biochemistry & Molecular Biology
Aref Zayed, Sana'a A. Jaber, Jomana Al Hroot, Sahar Hawamdeh, Nehad M. M. Ayoub, Nidal A. A. Qinna
Summary: This study describes two new HPLC methods for quantifying capmatinib in vivo and in vitro, which support pharmacokinetic studies. The reliability of the HPLC methods in detecting capmatinib was demonstrated, making them suitable for bioanalytical labs.
Article
Oncology
Kristie A. Blum, Jeffrey G. Supko, Michael B. Maris, Ian W. Flinn, Andre Goy, Anas Younes, Suresh Bobba, Adrian M. Senderowicz, Sergey Efuni, Ronda Rippley, Gozde Colak, Patrick Trojer, Jeremy S. Abramson
Summary: The study demonstrates that Pelabresib is a safe and effective BET inhibitor that can suppress target genes and potentially modify disease pathways. This research provides a foundation for further investigation of Pelabresib in patients with myelofibrosis.
CANCER RESEARCH COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Maria Rosa Iaquinta, Carmen Lanzillotti, Chiara Mazziotta, Ilaria Bononi, Francesca Frontini, Elisa Mazzoni, Lucia Oton-Gonzalez, John Charles Rotondo, Elena Torreggiani, Mauro Tognon, Fernanda Martini
Summary: Mesenchymal stem cells (MSCs) play a crucial role in tissue engineering and regenerative medicine for bone tissue and cartilage. The regulation of miRNAs is important for MSCs differentiation, and dysregulation of miRNAs may be associated with osteoporosis, bone fractures, and bone cancer. Bone-associated circulating miRNAs could be useful biomarkers for diagnosis, follow-up, and treatment of cancer and metastases.
Meeting Abstract
Hematology
Michael Wang, Javier Munoz, Andre Goy, Frederick L. Locke, Caron A. Jacobson, Brian T. Hill, John M. Timmerman, Houston Holmes, Samantha Jaglowski, Ian W. Flinn, Peter A. McSweeney, David B. Miklos, John M. Pagel, Marie Jose Kersten, Weimin Peng, Lianqing Zheng, John M. Rossi, Rajul K. Jain, Arati V. Rao, Patrick M. Reagan
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)