Article
Health Care Sciences & Services
Jiunn-Chang Lin, Tsang-Pai Liu, Vivin Andriani, Muhammad Athoillah, Chih-Yang Wang, Pei-Ming Yang
Summary: This study identified a gene signature from the transcriptome of HCC patients that correlates with poorer prognoses, which is related to mitotic cell cycle regulation. Gene-drug association analysis suggests that taxanes, such as paclitaxel, may be potential drugs targeting this gene signature. HCC cell lines with mutant TP53 or wild-type CTNNB1 genes show increased sensitivity to paclitaxel treatment, indicating potential benefits for these patient populations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Leva Gorji, Zachary J. Brown, Timothy M. Pawlik
Summary: Hepatocellular carcinoma (HCC) is a common malignancy with increasing incidence globally. Existing treatments for HCC have a poor prognosis with high recurrence and mortality rates. Precision medicine and genetic analysis have the potential to improve individualized management of HCC by identifying unique tumor mutations and biomarkers. This review summarizes the role of precision medicine in the treatment of HCC by targeting molecular mutations and tumor biomarkers.
Review
Health Care Sciences & Services
Danijel Galun, Dragana Mijac, Aleksandar Filipovic, Aleksandar Bogdanovic, Marko Zivanovic, Dragan Masulovic
Summary: Hepatocellular carcinoma (HCC) is a major malignant disease worldwide. Despite advancements in surveillance, diagnosis, and treatment, the incidence and mortality rates remain high. Liver cirrhosis is a common risk factor for HCC, and the risks from both the tumor and cirrhosis should be considered. Precision medicine challenges the traditional approach by tailoring treatment based on individual molecular targets. Next-generation sequencing and genetic markers offer potential for better understanding HCC heterogeneity and identifying vulnerabilities. A shift towards a therapeutic-oriented approach is needed for personalized HCC treatment. Multidisciplinary approval is crucial for decision-making in precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Zhenxiao Wang, Hanjiao Qin, Shui Liu, Jiyao Sheng, Xuewen Zhang
Summary: Hepatocellular carcinoma (HCC) is the most common primary hepatocellular carcinoma (PHC), and early diagnosis is crucial for better prognosis. Recent advancements in precision medicine and understanding the biological mechanisms of HCC have led to the development of new diagnostic methods, such as emerging serum markers, liquid biopsies, molecular diagnosis, and improvements in imaging techniques. This review aims to summarize and analyze these scientific advances in early HCC diagnosis and discuss their application and limitations, providing a reference for further research and clinical practice.
CHINESE MEDICAL JOURNAL
(2023)
Article
Immunology
Bo Hu, Xiao-Bo Yang, Xin-Ting Sang
Summary: The study identified different immune-related clusters in hepatocellular carcinoma (HCC) and developed a robust tumor gene signature. By utilizing immune-related genes (IRGs), the research aimed to assist in explaining the heterogeneity of HCC and potentially develop more efficient individualized treatments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ke Shi, Yufei Bi, Xuanwei Zeng, Xianbo Wang
Summary: This study aimed to investigate the effects of Huaier granule on the 3-year overall survival rate of patients at different clinical stages of hepatocellular carcinoma (HCC). The results showed that adjuvant Huaier therapy improved the survival rate of patients with HCC, indicating a dose-response pattern. However, further prospective clinical studies are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Mingwei Dong, Jing Chen, Yiran Deng, Danying Zhang, Ling Dong, Dalong Sun
Summary: This study found that overexpression of H2AFZ is associated with tumor malignancy and poor prognosis in HCC patients, potentially promoting rapid proliferation of HCC cells by regulating cell cycle signaling and DNA replication. Moreover, H2AFZ overexpression is regulated by TP53 mutation and is related to immune infiltrations and immune checkpoint genes in HCC, suggesting sensitivity to immune checkpoint blockades.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiulei Zhang, Zhihao Fu, Xiao Zhang
Summary: This study investigates the landscape of genomic alterations and lncRNA prognosis markers related to TP53 mutation in Hepatocellular carcinoma (HCC). TP53 mutation is associated with poor clinical outcomes in Stage II and Stage III HCC patients, affecting pathways like DNA replication, cell cycle, and immune response. Two lncRNAs (RP4-736L20.3 and SNRK-AS1) are identified as significant prognosis markers for HCC patients with TP53 mutation.
ONCOTARGETS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Hamish Innes, Pierre Nahon
Summary: More than 50,000 people are diagnosed with hepatocellular carcinoma (HCC) in Europe every year. Despite being known to liver centers before the presentation of HCC, it is often detected at a late stage with a poor prognosis. Uniform surveillance for all cirrhosis patients has been recommended for over two decades, but its implementation has been inefficient. Personalized surveillance, using individualized HCC risk models, is gaining support in the clinical community. However, these risk models are not yet widely used in routine care.
JOURNAL OF HEPATOLOGY
(2023)
Review
Oncology
Tian-Run Lv, Hai-Jie Hu, Parbatraj Regmi, Fei Liu, Fu-Yu Li
Summary: Sarcomatoid hepatocellular carcinoma (SHCC) is a rare subtype of primary liver malignancies. Compared to conventional hepatocellular carcinoma (HCC), SHCC has worse prognosis and exhibits more aggressive behavior.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ah-Jung Jeon, Chukwuemeka George Anene-Nzelu, Yue-Yang Teo, Shay Lee Chong, Karthik Sekar, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Alexander Yaw Fui Chung, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D. dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K. P. Goh, Roger Sik Yin Foo, Pierce Kah-Hoe Chow
Summary: Through analyzing the tumors and normal tissues of 30 patients with early-stage hepatocellular carcinoma, we identified aberrant epigenetic events and genes associated with disease prognosis. We found genes that are associated with enhancers and their upregulation is associated with worse prognosis.
Article
Immunology
Tao Zhang, Jian Gu, Xinyi Wang, Yaoyao Lu, Kailin Cai, Huili Li, Yingli Nie, Xiangdong Chen, Jiliang Wang
Summary: This study identified hepatocyte-specific zonation markers and classified hepatocellular carcinoma (HCC) into three subgroups based on these markers, including non-zonational-like, central-like, and portal-like clusters. The study evaluated the prognostic value, clinical characteristics, transcriptome and mutation features, immune infiltration, and immunotherapy response of each cluster, providing new perspectives on the heterogeneity of HCC and guiding precision medicine for HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Summary: The traditional method of tumor biopsy for hepatocellular carcinoma is limited and there is a need for a novel non-invasive diagnostic technique; circulating tumor DNA technology provides an important method for cancer screening, diagnosis, treatment selection, and prognosis prediction in hepatocellular carcinoma.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Genetics & Heredity
Yang Yang, Yajuan Qu, Zhaopeng Li, Zhiyong Tan, Youming Lei, Song Bai
Summary: This study provides a detailed analysis of TP53-mutated hepatocellular carcinoma (HCC), offering new insights for individualized therapy and accurate prognosis prediction.
FRONTIERS IN GENETICS
(2022)
Review
Gastroenterology & Hepatology
Jingwei Wei, Hanyu Jiang, Yu Zhou, Jie Tian, Felipe S. Furtado, Onofrio A. Catalano
Summary: High postoperative recurrence rates in hepatocellular carcinoma (HCC) pose a challenge in its management. Current methods for evaluating the pathophysiological and molecular characteristics of HCC preoperatively are insufficient. Radiomics, using artificial intelligence techniques, can extract key features from medical images to accurately assess the risk stratification of HCC patients. Comprehensive integration of radiomics, clinical, and/or multi-omics data can also improve the prediction of treatment response and prognosis.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Nutrition & Dietetics
Yong-le Zhan, Yong-an Zhan, Shi-xue Dai
CLINICAL NUTRITION
(2018)
Review
Gastroenterology & Hepatology
Shao-Zhuo Huang, Zhi-Cheng Liu, Wei-Xin Liao, Jun-Xiao Wei, Xiao-Wen Huang, Chen Yang, Yu-Han Xia, Lu Li, Chao Ye, Shi-Xue Dai
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Oncology
Chen Yang, Xiaowen Huang, Zhicheng Liu, Wenxin Qin, Cun Wang
MOLECULAR ONCOLOGY
(2020)
Article
Biology
Chen Yang, Hailin Zhang, Mengnuo Chen, Siying Wang, Ruolan Qian, Linmeng Zhang, Xiaowen Huang, Jun Wang, Zhicheng Liu, Wenxin Qin, Cun Wang, Hualian Hang, Hui Wang
Summary: Pharmacologic perturbation projects have generated expression data for computational therapeutic discovery, but optimal methodologies and parameters are still unclear. This study developed benchmarking standards and determined an optimal approach for drug retrieval. The candidate agent HHT was validated and shown to have therapeutic effects on liver cancer.
Review
Pediatrics
Qi-Qi Li, Hui-Hong Zhang, Shi-Xue Dai
Summary: Very early onset inflammatory bowel disease (VEO-IBD) is characterized by multifactorial chronic recurrent intestinal inflammation. Recent studies found that genetic and immunologic abnormalities are closely related to VEO-IBD.
FRONTIERS IN PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Chen Yang, Hailin Zhang, Linmeng Zhang, Andrew X. Zhu, Rene Bernards, Wenxin Qin, Cun Wang
Summary: This review summarizes the latest clinical advances in the treatment of advanced hepatocellular carcinoma, including molecular-targeted monotherapies, immuno-oncology monotherapies, combination therapies and novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Genetics & Heredity
Chen Yang, Senquan Zhang, Zhuoan Cheng, Zhicheng Liu, Linmeng Zhang, Kai Jiang, Haigang Geng, Ruolan Qian, Jun Wang, Xiaowen Huang, Mo Chen, Zhe Li, Wenxin Qin, Qiang Xia, Xiaonan Kang, Cun Wang, Hualian Hang
Summary: This study proposes a new sampling strategy to investigate the heterogeneity of hepatocellular carcinoma (HCC) and reveals the significant impact of spatial distribution on heterogeneity estimation. The findings provide insights into the complex phenotypes of HCC and offer a new risk stratification method to predict patient outcomes.