Review
Medicine, General & Internal
Iman M. M. Talaat, Noha M. M. Elemam, Shroque Zaher, Maha Saber-Ayad
Summary: Colorectal cancer is a prevalent cancer type worldwide, and the immune cells within the tumor microenvironment play a crucial role in its initiation and progression. Immune checkpoint molecules are highlighted as potential targets for immunotherapy in colorectal cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Feifei Guo, Yi Zhang, Ling Bai, Jiuwei Cui
Summary: Cancer stem cells (CSCs) are a small group of cancer cells with stem cell-like properties, which can be used for identifying malignant tumor phenotypes and patients with poor prognosis. Targeting CSCs has been shown to improve the effectiveness of cancer therapies. However, CSCs are resistant to conventional treatment methods such as radiotherapy and chemotherapy, hence the need for more effective anti-CSC therapies.
Article
Oncology
Piera Filomena Fiore, Paola Vacca, Nicola Tumino, Francesca Besi, Andrea Pelosi, Enrico Munari, Marcella Marconi, Ignazio Caruana, Vito Pistoia, Lorenzo Moretta, Bruno Azzarone
Summary: Wilms' tumor is a common childhood renal tumor with treatment challenges in developing new strategies for minimizing adverse effects. Research has shown that WT affects the activity of NK cells, leading to an unfavorable immune environment.
Article
Immunology
Huiting Xiao, Jiashuai Zhang, Kai Wang, Kai Song, Hailong Zheng, Jing Yang, Keru Li, Rongqiang Yuan, Wenyuan Zhao, Yang Hui
Summary: In this study, a novel method called Tumor-infiltrating Immune Cell Proportion Estimator (TICPE) was introduced to estimate the proportion of immune cells in specific types of cancer. The TICPE, based on relative expression orderings of gene pairs, showed superior accuracy in estimating immune cell proportion compared to other methods, and it was found to be insensitive to batch effects. Additionally, TICPE demonstrated the ability to detect prognostic signals in patients with tumors and changes in immune cell fractions during immunotherapy in melanoma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xiaobao Yang, Jinrong Lin, Guanzheng Wang, Dakang Xu
Summary: This study suggests that targeting proliferating tumor-infiltrating macrophages may increase CD8(+) cytotoxic lymphocyte (CTL) infiltration and facilitate the spatial redistribution of CD8(+) T cells in tumors, contributing to the antitumor effect.
Article
Immunology
Jingping Zhou, Shaolong Zhang, Changying Guo
Summary: The tumor microenvironment is shaped by various cell types that interact with tumor cells to influence tumor development. Macrophages and NK cells play a crucial role in regulating the immune response within the TME through cytokine signaling and cell-to-cell interactions, affecting the efficacy of immune responses against cancer cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Federica Portale, Diletta Di Mitri
Summary: Natural killer cells (NK) are innate lymphocytes with the ability to recognize and kill cancer cells, making them a promising candidate for cancer treatment. However, cancer can impair the function of NK cells, limiting their effectiveness in cell therapies. Extensive research has been conducted to understand the mechanisms of NK cell dysfunction in cancer and to find ways to enhance their anti-tumor function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Andrea Pelosi, Piera Filomena Fiore, Sabina Di Matteo, Irene Veneziani, Ignazio Caruana, Stefan Ebert, Enrico Munari, Lorenzo Moretta, Enrico Maggi, Bruno Azzarone
Summary: Neuroblastoma and Wilms' tumor are common childhood solid extracranial tumors, and the challenge lies in developing new therapeutic strategies to reduce adverse effects. Studying the immune environment can identify new therapeutic targets, such as the immunosuppressive activity of tumor cells on natural killer cells and monocytes. Natural killer cells play a crucial role in controlling cancer, but tumor cells can inhibit their function through various mechanisms, including the establishment of an immunosuppressive tumor microenvironment.
Review
Oncology
Irene Mattiola
Summary: NK cells play an important role in anti-cancer immunity, efficient in controlling metastasis but limited in fighting primary tumors due to tumor escape mechanisms. These mechanisms not only induce NK cell tolerance but also interfere with NK cell-dependent immune networking. This review discusses strategies to unleash NK cells in cancer by understanding and overcoming tumor escape mechanisms.
Article
Biochemistry & Molecular Biology
Yuhua Chen, Hao Zhou, Zhendong Wang, Zhanghao Huang, Jinjie Wang, Miaosen Zheng, Xuejun Ni, Lei Liu
Summary: This study analyzed the ceRNA network and tumor-infiltrating immune cells in ESCA, identifying key molecules and immune cells associated with the cancer. Prognostic models were established based on this analysis, providing an effective bioinformatics basis for exploring potential biomarkers and predicting the prognosis of ESCA.
BIOSCIENCE REPORTS
(2021)
Review
Oncology
Hongdan Chen, Yizeng Sun, Zeyu Yang, Supeng Yin, Yao Li, Mi Tang, Junping Zhu, Fan Zhang
Summary: In breast cancer, the metabolism of immune cells in different microenvironments is crucial for immunotherapy, and lipid metabolism may support an immunosuppressive microenvironment. Understanding the metabolic patterns and effects of immune cells in different microenvironments is essential for antitumor therapy.
Article
Genetics & Heredity
Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Jiao Yang, Juan Zhang, Jin Yang
Summary: By analyzing gene expression and immune cells, this study found a correlation between immune-related genes and immune cells with the response to neoadjuvant chemotherapy in breast cancer, highlighting the significance of combining neoadjuvant chemotherapy with immunotherapy for better clinical benefits.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Kele Cui, Shouxin Hu, Xinyu Mei, Min Cheng
Summary: The review discusses recent progress in research on innate immune cells in the esophageal cancer microenvironment, highlighting potential directions for the development of new biomarkers and effective intervention targets. Understanding the innate immunological mechanisms involved in esophageal mucosa carcinogenesis is crucial for clinical immunotherapy and prognosis prediction for patients with EC.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yan Zhang, Hui Yang, Jun Zhao, Ping Wan, Ye Hu, Lv Kun, YiRen Hu, Xi Yang, Mingzhe Ma
Summary: The study revealed that in TAMs in gastric cancer patients, increased levels of MAT2A play a role in the activation and maintenance of TAMs phenotype, mediating the upregulation of RIP1. This finding sheds light on the regulatory role of methionine metabolism in the anti-inflammatory function of monocytes in GC, with MAT2A potentially serving as a therapeutic target.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang, Jun Zhang
Summary: The study highlights the crucial role and potential impact of m(1)A modification patterns in the tumor microenvironment, particularly in influencing the prognosis of colon cancer patients and immune cell infiltration. The analysis of m(1)A score plays a significant role in understanding the complexities and diversity of the immune response in the context of cancer.