Review
Medicine, General & Internal
Kaifeng Tang, Jingting Liu, Baoqing Liu, Chunyan Meng, Jianhua Liao
Summary: This meta-analysis study indicates that high SOX2 expression is associated with poor prognosis in gastric cancer patients, serving as an independent prognostic marker. Moreover, SOX2 expression is also correlated with increased tumor invasion depth and positive vascular invasion.
Article
Immunology
Xiaoqing Shi, Sen Li, Yuanyuan Wang, Chuang Liu, Peipei Liu, Dongchun Qin
Summary: Objective: To develop a new scoring system based on platelet-to-lymphocyte ratio (PLR) and CA199 to predict the prognosis of gastric cancer. This study found that the PLR-CA199 score was associated with various clinical factors of gastric cancer and had a significant correlation with disease-free survival (DFS) and disease-specific survival (DSS) in both the training and validation cohorts. The PLR-CA199 score was identified as an independent prognostic factor for gastric cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Shaohua Huang, Liping Ma, Biyang Lan, Ning Liu, Wenwei Nong, Zhihu Huang
Summary: Through bioinformatic analyses, key dysregulated genes associated with the development of gastric cancer were identified, showing potential prognostic value. High expression of LRFN4 and LOC100506388 was linked to a higher risk of gastric cancer, while tumor infiltration levels were associated with overall survival in patients.
Review
Immunology
Apriliana E. R. Kartikasari, Emily Cassar, Mohammed A. M. Razqan, Crispin Szydzik, Cesar S. Huertas, Arnan Mitchell, Magdalena Plebanski
Summary: Circulating TNFR2 shows a correlation with various types of cancer, indicating its potential as a diagnostic biomarker.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Noor Bakour, Frank Moriarty, Gillian Moore, Tracy Robson, Stephanie L. Annett
Summary: High glucocorticoid receptor (GR) expression is associated with disease progression in gynaecological cancers and early stage, untreated triple negative breast cancers, but not prognostic in late stage, chemotherapy treated triple negative breast cancers. Additional studies are needed to elucidate the tumour specific function of the GR receptor for targeted therapy.
Article
Oncology
Xinyue Qin, Yinhao Chen, Shuo Ma, Lei Shen, Shaoqing Ju
Summary: TM4SF18 is a promising biomarker for gastric cancer, promoting proliferation, migration, and invasion abilities of GC cells, and being associated with immune response.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Yu An, Gulimirerouzi Fnu, Changchun Xie, Georg F. F. Weber
Summary: This study conducted a comprehensive analysis of splice variants of Osteopontin and found that they have different expression patterns in various cancer patients, which are related to tumor grade, stage, and patient survival. However, there are still some discrepancies that need further investigation to clarify the diagnostic, prognostic, and potentially predictive potential of Osteopontin splice variants.
Review
Oncology
Dan Zhang, Jingting Liu, Mengxia Zheng, Chunyan Meng, Jianhua Liao
Summary: Increased CD155 expression is associated with poor prognosis in cancer patients, particularly in digestive system cancer, hepatobiliary pancreatic cancer, digestive tract cancer, breast cancer, lung cancer, and head and neck cancer. Additionally, enhanced CD155 expression is significantly correlated with advanced tumor stage, lymph node metastasis, and distant metastasis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Zehan Li, Shengchao Xu, Lin Chen, Shuqi Huang, Xieyida Kuerban, Tianyu Li
Summary: This study investigated the association between ING3 expression and the prognosis of cancer patients. The results showed that high expression of ING3 was negatively associated with advanced TNM stage, lymph node metastasis, and disease-free survival. However, it was not associated with overall survival, tumor size, tumor differentiation, and gender.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemical Research Methods
Yuan Gu, Ying Gao, Xiaodan Tang, Huizhong Xia, Kunhe Shi
Summary: The study found that CPZ is overexpressed in multiple types of cancer, including gastric cancer, and its overexpression is significantly associated with poor prognosis in STAD. CPZ expression levels are correlated with immune infiltration and diverse immune marker sets in STAD, indicating its potential role as a biomarker for GC.
CURRENT BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Wenfang Zhao, Jiahui Lin, Sha Cheng, Huan Li, Yufeng Shu, Canxia Xu
Summary: This study found that COMMD10 was highly expressed in gastric adenocarcinoma (STAD) and was associated with poor prognosis. Additionally, COMMD10 was related to m6A modification and immune infiltration in STAD.
Article
Oncology
Chia-Lang Fang, Yu-Feng Tian, Shiau-Shiuan Lin, Shih-Ting Hung, You-Cheng Hseu, Chun-Chao Chang, Chia-Lin Chou, Li-Chin Chen, Wen-Ching Wang, Kai-Yuan Lin, Ding-Ping Sun
Summary: Gastric cancer is the 4th most common and 3rd deadliest cancer worldwide. This study investigated the relationship between GRK3 and gastric cancer prognosis and explored the role of GRK3 in gastric cancer development. The researchers found that GRK3 overexpression was significantly associated with metastasis, TNM stage, and vascular invasion. High GRK3 expression was also linked to shorter disease-free survival and overall survival in patients. Knocking down GRK3 in gastric cancer cells inhibited cell proliferation, migration, and invasion. The findings suggest that GRK3 could potentially serve as a biomarker for gastric cancer prognosis and a target for therapy.
Article
Genetics & Heredity
Li Wang, Shan Cao, Rujun Zhai, Yang Zhao, Guodong Song
Summary: This study systematically analyzed the expression, prognostic values, mutations, and functional networks of the lysyl oxidase (LOX) family in gastric cancer (GC) using various databases. The results suggested that LOX and LOXL2 may play crucial roles in the oncogenesis of GC and could potentially serve as biomarkers for predicting tumor prognosis and targets for therapy.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Mengxia Zheng, Jingting Liu, Chunyan Meng, Kaifeng Tang, Jianhua Liao
Summary: The study found that high levels of miR-140 are associated with better overall survival in cancer patients, especially those with cancers in different parts of the body. On the other hand, low levels of miR-140 are related to advanced TNM stage, worse histologic grade, and positive lymph node metastasis status.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weimin Wang, Ke Min, Gaoyang Chen, Hui Zhang, Jianliang Deng, Mengying Lv, Zhihong Cao, Yan Zhou
Summary: This study identified key co-expression module MEyellow related to GC metastasis using WGCNA, and discovered several new biomarkers. FAM30A and TIMD4 could be effective markers for predicting prognosis and therapeutic targets in GC.
Article
Urology & Nephrology
Ming-Wei Ma, Xian-Shu Gao, Feng Lyu, Xiao-Bin Gu, Huan Yin, Hong-Zhen Li, Xiao-Ying Li, Xin Qi, Yun Bai, Jia-Yan Chen
Summary: The study identified risk predictors for prostate cancer metastasis using contemporary data and assessed the performance of bone imaging indications recommended by NCCN, AUA, and EAU guidelines. Histologic grade group (GG) 5 was found to be the primary factor for distant metastasis (DM) and bone(s)-only metastasis (BM), with NCCN-based recommendations showing higher rationality in clinical practice and nomograms predicting metastasis demonstrating high accuracy.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Mu Xie, Xian-Shu Gao, Ming-Wei Ma, Xiao-Bin Gu, Hong-Zhen Li, Feng Lyu, Yun Bai, Jia-Yan Chen, Xue-Ying Ren, Ming-Zhu Liu
Summary: In this study, the NCCN-g and AUA-g risk stratification systems showed better discrimination ability in predicting prostate cancer-specific mortality compared to the EAU-g system. Specifically, the discrimination ability of the NCCN-g system was found to be superior to that of the AUA-g system.
FRONTIERS IN ONCOLOGY
(2021)
Article
Education, Scientific Disciplines
Meilian Dong, Xiaobin Gu, Taoran Ma, Yin Mi, Yonggang Shi, Ruitai Fan
Summary: NECC is an aggressive disease with controversial role of radiotherapy in treatment. Radiotherapy showed no significant difference in M0 group (without metastasis) but significant difference in M1 group (with metastasis), positively impacting the survival rate of patients.
Article
Biotechnology & Applied Microbiology
Shiliang Dong, Minrui Ma, Ming Li, Yuexin Guo, Xiaoxiao Zuo, Xiaobin Gu, Mingzhi Zhang, Yonggang Shi
Summary: MEG3 and RBMS3 are low-expressed in breast cancer, negatively correlated with miR-141-3p, and positively correlated with each other. MEG3 inhibits BC cell proliferation and promotes apoptosis by down-regulating miR-141-3p and up-regulating RBMS3.
Article
Cell Biology
Xiaobin Gu, Yonggang Shi, Meilian Dong, Li Jiang, Jing Yang, Zheyan Liu
Summary: The study revealed that TAM-derived exosomes transfer hsa_circ_0001610 to EC cells, leading to a reduction in radiosensitivity by upregulating cyclin B1 expression through adsorbing miR-139-5p.
CELL DEATH & DISEASE
(2021)
Letter
Surgery
Huan-Gai Zhang, Liu Yang, Zong-Xu Qiao, Wei Guo
ASIAN JOURNAL OF SURGERY
(2022)
Article
Emergency Medicine
Wei Guo, Ning Wang, Zhaobo Cui, Wenjing Liu, Shufen Guo, Xiaoya Yang, Yajing Liu, Liye Shao, Jing Wang
Summary: This study found that FeNO levels have clinical value in diagnosing PH in patients with AECOPD. FeNO levels were higher in patients with mild PH and were positively correlated with C-reactive protein in AECOPD patients while negatively correlated with brain natriuretic peptide in the AECOPD + PH group.
EMERGENCY MEDICINE INTERNATIONAL
(2022)
Article
Oncology
Xin-Yu Sun, Yu Lin, Wei Guo, Xiao-Ming Yin
Summary: This study utilizes a meta-analysis to demonstrate the prognostic and clinicopathological value of the geriatric nutritional risk index (GNRI) in non-small cell lung cancer (NSCLC). The findings indicate that a low GNRI score is associated with poor survival outcomes and specific clinicopathological characteristics in NSCLC patients.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Pathology
Zhaoyang Yan, Tongxin Xu, Juntao Lu, Zheng Wu, Xiaoxu Li, Jinsheng Xu, Wei Guo, Zhiming Dong
Summary: NRSN2 is upregulated in esophageal squamous cell carcinoma (ESCC) and is associated with malignancy and poor prognosis. NRSN2 is transcribed by E2F1 and promotes proliferation, migration, and invasion of ESCC cells by activating the AKT/mTOR pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Genetics & Heredity
Wei Guo, Kun Mu, Wen-Shuai Li, Shun-Xing Gao, Lin-Feng Wang, Xiao-Ming Li, Jian-Yong Zhao
Summary: By bioinformatic analysis, we identified key genes involved in immune cell infiltration during intervertebral disc degeneration and revealed the crucial role of MFN2 in NP cell pyroptosis and NLRP3 inflammasome activation. We speculate that increased MFN2 expression and infiltration of CD8(+) T cells, NK cells, and neutrophils play important roles in the pathogenesis of intervertebral disc degeneration.
FRONTIERS IN GENETICS
(2023)
Review
Oncology
Wei Guo, Yun-Chuan Sun, Li -Yuan Zhang, Xiao-Ming Yin
Summary: IMRT has significant advantages in radiation therapy for prostate cancer, reducing acute gastrointestinal adverse events but slightly increasing acute genitourinary adverse events. There is no significant difference in late gastrointestinal and genitourinary adverse events. In terms of biochemical control, IMRT is significantly better than 3D-CRT.
Article
Oncology
Wei Guo, Bin Wang, Li-Yuan Zhang, Yun-Chuan Sun, Tao Xue
Summary: The objective of this study was to investigate the use of 3D printing technology for customizing precise radiotherapy head masks in cranial radiotherapy patients. The results showed that the 3D printing head masks had good performance in terms of deep dose attenuation, body surface dose, and positioning accuracy compared to traditional thermoplastic head films.
Article
Oncology
Ling Li, Jingqun Wang, Shuxia Geng, Fang Liu, Lili Ping, Xiaohong Gu, Xueai Fan, Mei Yang, Lixia Liang, Wei Guo
Summary: The study found that the combination of S-adenosylmethionine (SAM-e) and Si Mo Tang is effective in treating neonatal jaundice. Compared to using SAM-e or Si Mo Tang alone, the combination treatment promotes the regression of jaundice, improves liver function, neurodevelopmental conditions, and myocardial enzyme spectrum, reduces inflammation, and improves immune function in newborns with neonatal jaundice.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ling Li, Jing-Qun Wang, Shu-Xia Geng, Fang Liu, Li-Li Ping, Xiao-Hong Gu, Xue-Ai Fan, Mei Yang, Li-Xia Liang, Wei Guo
Summary: This study identified sepsis, TSB, and B/A ratio as risk factors for predicting acute bilirubin encephalopathy (ABE).
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Yifang Shui, Mengquan Li, Jing Su, Mingxun Chen, Xiaobin Gu, Wenzhi Guo
Summary: This meta-analysis indicates that elevated SII is significantly associated with poor prognosis in patients with pancreatic cancer, including OS, RFS/PFS/DFS, and CSS, while showing no significant correlation with other clinicopathological parameters.
