Article
Biotechnology & Applied Microbiology
Li-ying Zhang, Jia-ying Yu, Yan-long Leng, Ran-ran Zhu, Hong-xian Liu, Xin-yu Wang, Ting-ting Yang, Yi-ning Guo, Jing-ling Tang, Xin-chen Zhang
Summary: The study identified miR-181c as downregulated in PTX-resistant ovarian cancer cells and tissues, which induced apoptosis and inhibited the PI3K/Akt pathway by directly targeting GRP78. Overexpression of miR-181c sensitized resistant ovarian cancer to PTX, suggesting a potential therapeutic strategy.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Summary: The study revealed that circ_PTN promotes DDP resistance in GBM cells through activating the PI3K/AKT pathway, with in vivo experiments demonstrating that circ_PTN silencing inhibits DDP resistance in GBM tumors.
MOLECULAR THERAPY NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Vivek Makwana, Santosh Rudrawar, Shailendra Anoopkumar-Dukie
Summary: Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways play crucial roles in the proliferation and survival of prostate cancer cells by increasing androgen receptor expression and protein levels. Inhibition of a single pathway is insufficient to halt disease progression, suggesting that targeting multiple pathways at common junctions may be beneficial for effective management of prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mingkai Liu, Guiyang Xue, Rixu Liu, Yi Wang, Xiaoqian Sheng, Wei Sun
Summary: This study found that Platycodi radix saponins (SPR) and microRNAs (miRNAs) can affect the proliferation, migration and invasion ability of colorectal cancer (CRC) cells by regulating the PI3K/AKT pathway.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Hongyu Li, Xin Shen, Mengjun Ma, Wenzhou Liu, Wen Yang, Peng Wang, Zhaopeng Cai, Rujia Mi, Yixuan Lu, Jiahao Zhuang, Yuhang Jiang, Yihui Song, Yanfeng Wu, Huiyong Shen
Summary: The study revealed that ZIP10 drives OS proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway, which might serve as a target for OS treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Karen Y. P. S. Avelino, Leony S. Oliveira, Maryana R. Santos, Norma Lucena-Silva, Cesar A. S. Andrade, Maria D. L. Oliveira
Summary: This study developed a novel label-free electrochemical biosensor for detecting the BCR/ABL fusion gene, demonstrating high sensitivity and specificity in analyzing clinical samples from patients with chronic myeloid leukemia. The biosensor showed a linear response range, high reproducibility, and fast analytical response, making it a promising tool for early cancer diagnosis.
BIOELECTROCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chunmei Guo, Nannan Li, Chengyong Dong, Liming Wang, Zhaopeng Li, Qinlong Liu, Qinglai Ma, Frederick T. Greenaway, Yuxiang Tian, Lihong Hao, Shuqing Liu, Ming-Zhong Sun
Summary: The study highlighted the significant upregulation of 33-kDa ANXA3 in hepatocarcinoma tissues and demonstrated that its knockdown can suppress malignancy and induce apoptosis in hepatocarcinoma cells. It also showed effects on proliferation and invasion abilities of cells, indicating a potential role for 33-kDa ANXA3 as a target for hepatocarcinoma diagnosis and treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Neurosciences
Jianhui Liu, Pu Ai, Yiyan Sun, Xiaoyu Yang, Chunhong Li, Yihan Liu, Xiaohuan Xia, Jialin C. Zheng
Summary: This study demonstrated that propofol inhibits microglial activation through the miR-106b/Pi3k/Akt axis, revealing a novel molecular mechanism of propofol-mediated immunomodulatory effects. The findings imply potential therapeutic applications of propofol for treating neuroinflammation-related neurodegenerative diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Junbao Yang, Weilong Ding, Xiangyu Wang, Yongsheng Xiang
Summary: REV7 is highly expressed in glioma tissues and plays a crucial role in the chemosensitivity of glioma cells by regulating proliferation, apoptosis, and sensitivity to chemotherapy through the phosphoinositide 3-kinase signaling pathway. Targeting DNA polymerase zeta via REV7 may improve the sensitivity of glioma cells to chemotherapy.
Article
Biology
Chao Xu, Qinwen Ye, Chao Ye, Shaojun Liu
Summary: circACTR2 is down-regulated in pancreatic cancer cells and can reverse chemoresistance by inhibiting the PI3K/AKT signaling pathway through sponge miR-221-3p and upregulating PTEN expression.
Article
Genetics & Heredity
Xiaofeng Wang, Rui He, Li Geng, Jing Yuan, Huijie Fan
Summary: This study aimed to investigate whether Ginsenoside Rg3 can alleviate cisplatin resistance and enhance cisplatin-induced apoptosis in gastric cancer cells, and to explore the underlying molecular mechanisms. It was found that miR-429, expression of which was restored by Ginsenoside Rg3 treatment, was associated with cisplatin resistance in gastric cancer cells. The study also demonstrated that miR-429 contributed to chemosensitivity in gastric cancer cells partly through the regulation of SOX2. Overall, Ginsenoside Rg3 enhanced chemosensitivity and inhibited migration of cisplatin-resistant gastric cancer cells mainly by targeting miR-429 and modulating PI3K/AKT/mTOR signaling.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Lu Liu, Lin Yang, Xiaojun Liu, Menghan Liu, Jing Liu, Xuefeng Feng, Ziyuan Nie, Jianmin Luo
Summary: This study found that the expression of SEMA4D is increased in AML patients and is associated with risk stratification and prognosis. SEMA4D promotes the proliferation and inhibits apoptosis of AML cells by binding to its receptor, PlexinB1, and reduces the sensitivity of AML cells to daunorubicin. Furthermore, SEMA4D/PlexinB1 promotes the proliferation and survival of AML cells by activating the PI3K/Akt signaling pathway. The anti-SEMA4D antibody VX15/2503 can inhibit the proliferation of AML cells in xenograft mouse models, thereby inhibiting the development of AML.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yao Tian, Zhao-Hui Chen, Peng Wu, Di Zhang, Yue Ma, Xiao-Feng Liu, Xin Wang, Dan Ding, Xu-Chen Cao, Yue Yu
Summary: The deficiency of MIR497HG contributes to breast cancer progression and tamoxifen resistance by downregulating miR-497/195. miR-497/195 collectively represses five PI3K-AKT regulators, resulting in inhibition of PI3K-AKT signaling. Additionally, ERα binds to the MIR497HG promoter to activate its transcription in an estrogen-dependent manner. ZEB1 interacts with HDAC1/2 and DNMT3B at the MIR497HG promoter, leading to promoter hypermethylation and histone deacetylation.
Article
Multidisciplinary Sciences
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Juecker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Mueschen, Juergen Ruland, Maike Buchner
Summary: Current therapeutic approaches in CLL focus on suppressing the PI3K/AKT signaling pathway, but research shows that CLL cells are vulnerable to hyperactivation of this pathway, which may be a promising concept for CLL therapy.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Xun Lai, Jia Wei, Xue-zhong Gu, Xiang-mei Yao, Di-si Zhang, Feng Li, Yun-yan Sun
Summary: This study unraveled the molecular mechanism by which LINC00470 reduces PTEN stability via RNA methyltransferase METTL3, leading to the inhibition of cell autophagy and promotion of chemoresistance in CML.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
