Article
Multidisciplinary Sciences
Jesus Gonzalez Bosquet, Eric J. Devor, Andreea M. Newtson, Brian J. Smith, David P. Bender, Michael J. Goodheart, Megan E. McDonald, Terry A. Braun, Kristina W. Thiel, Kimberly K. Leslie
Summary: This study aims to create and validate accurate prediction models for treatment response in HGSC by integrating comprehensive clinical and genomic data. The models achieved prediction performances of over 95% in AUC by integrating clinical and genomic variables. Most performances in the validation set did not differ from the training set, but models with DNA methylation or lncRNA underperformed in the validation set.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ryon P. Graf, Ramez Eskander, Leo Brueggeman, Dwayne G. Stupack
Summary: This study showed that a CNV-based risk score is independent of and superior to current or future genomic biomarkers for ovarian cancer in predicting overall survival. The identified CNV regions were not strongly associated with canonical ovarian cancer biological pathways, indicating potential candidates for future mechanistic investigations. External validation of the CNV risk score, especially in conjunction with more extensive clinical features, could be pursued through existing FDA-approved assays.
Article
Oncology
Marko Hojnik, Natasa Kenda Suster, Spela Smrkolj, Damjan Sisinger, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: This study evaluated the levels of AKR1B1 and AKR1B10 in patients with high-grade serous ovarian cancer and their association with clinicopathological characteristics, survival, and response to chemotherapy. The results showed that higher AKR1B1 levels were associated with better disease-free survival, making it a potential prognostic biomarker for this cancer. However, AKR1B1 and AKR1B10 were not associated with different responses to chemotherapy.
Article
Multidisciplinary Sciences
He Li, Nayiyuan Wu, Zhao-Yi Liu, Yong-Chang Chen, Quan Cheng, Jing Wang
Summary: This study highlights the important roles of transcription factors (TFs) in serous ovarian cancer (SOC) and develops a 17-TFs related prognostic signature to accurately predict the survival of SOC patients. Analysis of immune infiltration and treatment responses show significant differences between high-risk and low-risk groups, providing insights for personalized therapy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Mireia Crispin-Ortuzar, Ramona Woitek, Marika A. V. Reinius, Elizabeth Moore, Lucian Beer, Vlad Bura, Leonardo Rundo, Cathal McCague, Stephan Ursprung, Lorena Escudero Sanchez, Paula Martin-Gonzalez, Florent Mouliere, Dineika Chandrananda, James Morris, Teodora Goranova, Anna M. Piskorz, Naveena Singh, Anju Sahdev, Roxana Pintican, Marta Zerunian, Nitzan Rosenfeld, Helen Addley, Mercedes Jimenez-Linan, Florian Markowetz, Evis Sala, James D. Brenton
Summary: High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease with difficulties in predicting response to chemotherapy. This study presents a framework that integrates baseline clinical data, blood-based markers, and radiomic biomarkers to predict the response of patients to chemotherapy. The results show that incorporating radiomics data into the model significantly improves prediction accuracy.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Daniela Travaglio Morales, Carlos Huerga Cabrerizo, Itsaso Losantos Garcia, Monica Coronado Poggio, Jose Manuel Cordero Garcia, Elena Lopez Llobet, Domenico Monachello Araujo, Sebastian Rizkallal Monzon, Luis Dominguez Gadea
Summary: This study evaluated the prognostic value of pretreatment 18F-FDG PET radiomic features in patients with HGSOC. The results indicated that TLG, GLSZM_ZSNU, and GLRLM_RLNU were significantly associated with DFS. Survival curve analysis showed a significant difference in DFS between patients with GLRLM_RLNU > 7388.3 and those with lower values, indicating that these features may be used for predicting the prognosis of HGSOC patients.
Article
Reproductive Biology
Lu Zhang, Ruiting Fu, Ping Liu, Lijun Wang, Weihua Liang, Hong Zou, Wei Jia, Lin Tao
Summary: ETS transcription factor ETV5 plays an oncogenic role in high-grade serous ovarian cancer (HGSOC), with overexpression associated with poor prognosis. ETV5 promotes proliferation, migration, and invasion capabilities of HGSOC cells, making it a high-risk factor for HGSOC progression. It can be used as a clinically effective biomarker to determine HGSOC patient prognosis.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
L. C. Hanker, A. El-Balat, Z. Drosos, S. Kommoss, T. Karn, U. Holtrich, G. Gitas, M. Graeser-Mayer, M. Anglesio, D. Huntsman, A. Rody, H. Gevensleben, F. Hoellen
Summary: High levels of SPHK1 expression were associated with better prognosis in ovarian cancer patients, particularly in those with high-grade serous ovarian cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shrabanti Chowdhury, Jacob J. Kennedy, Richard G. Ivey, Oscar D. Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R. Savage, Anna B. Berry, Boris Reva, Umut Ozbek, Azra Krek, Weiping Ma, Felipe da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J. Voytovich, Yajue Huang, Sun-Hee Lee, Lindsay Bergan, Travis D. Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N. Hoofnagle, Zachary T. Herbert, Alexey I. Nesvizhskii, Bing Zhang, Jeffrey R. Whiteaker, David Fenyo, Wilson McKerrow, Joshua Wang, Stephan C. Schuer, Vasileios Stathias, X. Steven Chen, Mary Helen Barcellos-Hoff, Timothy K. Starr, Boris J. Winterhoff, Andrew C. Nelson, Samuel C. Mok, Scott H. Kaufmann, Charles Drescher, Marcin Cieslik, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Summary: To enhance our understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we analyzed the proteogenomic landscape of 242 HGSOCs and identified a 64-protein signature that accurately predicts a subgroup of HGSOCs refractory to initial platinum-based therapy. We also found a significant association between the lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness, and identified 5 clusters of HGSOC based on pathway protein expression, which may represent different mechanisms of refractoriness and potential therapeutic vulnerabilities.
Article
Reproductive Biology
Ryoya Miyakawa, Makoto Kobayashi, Kotaro Sugimoto, Yuta Endo, Manabu Kojima, Yasuyuki Kobayashi, Shigenori Furukawa, Tsuyoshi Honda, Takafumi Watanabe, Shigeyuki Asano, Shu Soeda, Yuko Hashimoto, Keiya Fujimori, Hideki Chiba
Summary: In this study, researchers found that high expression of SPON1 protein is associated with lower 5-year recurrence-free survival rate in ovarian cancer. This study suggests that SPON1 may serve as a prognostic biomarker for ovarian cancer and could be used to predict outcomes.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Medicine, Research & Experimental
Nathalie D. Mckenzie, Sarfraz Ahmad, Ahmad Awada, Theresa M. Kuhn, Fernando O. Recio, Robert W. Holloway
Summary: The prognosis of high-grade serous ovarian cancer is influenced by the immune profile of the tumor microenvironment. Altering the gut microbiome and TME metabolism through dietary interventions may provide opportunities for immunomodulation.
Article
Biochemistry & Molecular Biology
Jie Wei Zhu, Fabian Wong, Agata Szymiczek, Gabrielle E. V. Ene, Shiyu Zhang, Taymaa May, Steven A. Narod, Joanne Kotsopoulos, Mohammad R. Akbari
Summary: Circulating tumor DNA (ctDNA) in post-surgical serum samples may predict the presence of microscopic residual disease and may be a predictor of recurrence among women with ovarian cancer, but larger studies are necessary to validate these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nan Zhang, Zhiyou Yang, Yue Jin, Shanshan Cheng, Jiani Yang, Yu Wang
Summary: The low expression of circ_0078607 in high-grade serous ovarian cancer (HGSOC) is associated with poor clinical outcomes, making it a potential predictor for unfavorable progression-free survival (PFS) and overall survival (OS) in patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Xiang Ye, Limei An, Xiangxiang Wang, Chenyi Zhang, Wenqian Huang, Chenggong Sun, Rongrong Li, Hanlin Ma, Hongyan Wang, Min Gao
Summary: ALOX5AP expression is significantly upregulated in SOC tissues compared to normal tissues, and high levels are associated with poor clinical features and prognosis in multiple SOC patient cohorts. ALOX5AP is primarily involved in immune response and regulation in SOC, indicating potential as an immunotherapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Mi Jiao, Wenbo Sun, Lina Li, Chunyan Li, Jing Zhou, Qian Li, Lian Duan
Summary: This study found that SPOCK2 is highly expressed in high-grade serous ovarian cancer (HGSOC) and can serve as a diagnostic and prognostic marker. SPOCK2 is mainly involved in regulating the extracellular matrix and immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Transportation Science & Technology
Jingke Zhang, Tao Zhu, Bing Yang, Xiaorui Wang, Shoune Xiao, Guangwu Yang, Yanwen Liu, Benhuai Li
Summary: The research shows that increasing the translational mass of the wheelset effectively reduces the difference in collision response, and the wheel lift is significantly reduced when the wheelset rotation is not considered.
INTERNATIONAL JOURNAL OF RAIL TRANSPORTATION
(2023)
Article
Materials Science, Multidisciplinary
Tao Zhu, Ying Xiong, Mingxue Shen
Summary: Magnesium alloy, characterized by high specific strength and stiffness, biocompatibility and degradability, is a promising material for orthopedic implants. However, its application is limited by the fast corrosion rate and poor wear resistance. This study investigated the corrosion and wear behavior of AZ80 magnesium alloy in simulated body fluid with different pH values. The results showed that the test environment significantly influenced the corrosion and wear behavior of the specimen. The corrosion resistance of the specimen improved with increasing pH value. The lubrication effect of the simulated body fluid was not observed, but it significantly reduced the wear volume of the specimen. The wear rate of the specimen in the simulated body fluid decreased with increasing pH value due to the synergistic effect of corrosion and wear.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Engineering, Electrical & Electronic
Lei Cai, Yuli Fu, Wanliang Huo, Youjun Xiang, Tao Zhu, Ying Zhang, Huanqiang Zeng, Delu Zeng
Summary: This article presents a high-performance multi-scale attentive neural architecture search (MANAS) framework for image de-raining. The proposed method automatically searches the internal multi-scale attentive architecture of the de-raining network through a gradient-based search algorithm, avoiding the cumbersome manual design process. Additionally, a practical and effective multi-to-one training strategy is proposed to optimize multiple loss functions for robust de-raining performance and controllable model complexity. Experimental results consistently demonstrate the superiority of the proposed method in both synthetic and realistic rainy images, as well as downstream vision applications.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2023)
Article
Optics
Jing Chai, Leilei Shi, Nan Guo, Liyang Jin, Jiali Li, Miaoxin Bai, Da Wei, Wei Huang, Min Liu, Tao Zhu
Summary: This paper theoretically and experimentally demonstrates a robust and efficient bidirectional coupler for whispering gallery mode (WGM) excitation, which is based on a long-period grating (LPG) inscribed in D-fiber. The LPG couples the fundamental core mode to the forward propagating cladding modes according to the phase-matching condition, enhancing the evanescent field and selectively exciting the WGM within a specific wavelength band. Experimental results show that high resonance contrast and quality factor can be achieved in the LPG coupled WGM resonator. Furthermore, the LPG-based WGM coupler exhibits bidirectionality, providing a reliable and flexible fiber coupler for practical applications.
Article
Health Care Sciences & Services
Lingcan Tan, Hong Yu, Junyu Yan, Chunyuan Liu, Kun Xiao, Jin Yin, Yunxia Zuo, Tao Zhu, Xiaoqian Deng
Summary: This study found that Chinese anesthesiologists faced difficulties in managing malignant hyperthermia, including challenges in obtaining dantrolene, lack of competency in managing MH, difficulty in obtaining professional help, and poor teamwork.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Review
Education & Educational Research
Hongyang Chen, Zining Wang, Lan Zheng, Jiumei Ciren, Weiyi Zhang, Tao Zhu
Summary: Anesthesiology education in Tibet lags behind, and clinical anesthesia needs improvement. Improving the overall quality of anesthesiology teachers in Tibet is advantageous for the development of local anesthesiology. Enhancing the teaching ability of anesthesiologists not only promotes the independent learning capability of young doctors, but also establishes a strong foundation for the smooth progress of clinical work.
FRONTIERS IN EDUCATION
(2023)
Article
Engineering, Mechanical
Chao Wang, Bing Yang, Tao Zhu, Xiaochen Tian, Shoune Xiao, Guangwu Yang
Summary: This study proposes an equivalent crack life prediction method for root cracks in T-welded joints. The severity of the weld defect is described using an equivalent initial defect. Fatigue life prediction is achieved using equivalent fracture parameters and high-stress fatigue life reference points to obtain a P-S-N curve for the entire stress range. The applicability of this method is compared and verified through test data under constant and equivalent spectral load for 6082-aluminum alloy T-welded joints.
FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES
(2023)
Article
Energy & Fuels
Mengye Jin, Tao Zhu, Shouheng Li, LiFeng Wang, Yusheng Liu, Yan Yu, Yiwei Han
Summary: In this study, CeMnOx-ZF catalysts with different metal loadings were prepared from coal fly ash (CFA) and their catalytic oxidation effects on toluene were investigated. The synergy between Ce and Mn metals in CeMnOx-ZF catalysts was studied. The optimized conditions for highest activity of CFA were determined, and the 20 wt.% CeMnOx-ZF catalyst exhibited a high toluene removal efficiency of up to 99.6% under optimized reaction conditions. The catalyst also showed high stability even after a 100-hour cycle test. This study provides a simple method for CFA activation and proposes a feasible strategy for designing high-efficiency catalysts for VOC degradation.
Article
Immunology
Xin Xia, Zhong-Ming Tan, Peng Wan, Hao Zheng, Rong Tang, Xiao-Qin Chen, Xi-Ling Guo, Tao Zhu, Jia-Lu Feng, Jin Zhong, Xiao-Long Li, Zhen-Yu Zhang, Feng-Cai Zhu, Jing-Xin Li
Summary: Vaccination with the orally aerosolised Ad5-nCoV could lead to the release of vaccine vector viral particles into the environment. However, improving the vaccine nebulizer could reduce the potential risk of viral particle exposure. This study assessed the environmental impact of aerosolized Ad5-nCoV by collecting air, swab, mask, and blood samples. Results showed a high proportion of positive samples during and after vaccination, indicating the possible spillage of viral particles. The study concludes that there is a risk of human exposure to vaccine vector viral particles during orally aerosolized Ad5-nCoV vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Optics
Haoting Wu, Nan Guo, Zixuan Zhong, Wencun Guo, Lei Han, Chongjian Li, Di Meng, Guolu Yin, Tao Liu, Tao Zhu
Summary: A high-performance distributed dynamic absolute strain sensing technique is proposed and demonstrated by synthesizing phi-OTDR and BOTDR. The technique combines the relative strain obtained by the f-OTDR part and the initial strain offset estimated by fitting the relative strain with the absolute strain signal from the BOTDR part. The experiment results show that the proposed technique can achieve distributed dynamic absolute strain sensing with a sensing dynamic range of over 2500 mu epsilon, a peak-to-peak amplitude of 1165 mu epsilon, and a wide frequency response range from 0.1 to over 30 Hz over a sensing range of about 1 km.
Review
Medicine, General & Internal
Bo Jiao, Mingyuan Chen, Shuanger Li, Yingying Jiang, Chan Chen, Tao Zhu
Summary: This article aims to investigate the risk factors for cognitive impairment in patients with COVID-19 through a systematic review and meta-analysis. The study shows that some hospitalized COVID-19 patients exhibit cognitive impairment-related neurological damage. This research will provide important evidence for the evaluation, prevention, and treatment of cognitive impairment in COVID-19 patients.
Review
Public, Environmental & Occupational Health
Kexin Jiang, Tingting He, Yongzhi Ji, Tao Zhu, Enshe Jiang
Summary: Nowadays, salt intake is too high and it is widely recognized that there is a close relationship between hypertension (HTN) and dietary salt intake. Long-term high salt intake has been found to increase blood pressure in both hypertensive and normotensive individuals. High salt intake in the public increases cardiovascular risk, salted-related HTN, and other HTN-associated outcomes. This review aims to present the prevalence of HTN and trends in salt intake in the Chinese population, discuss the risk factors, causes, and mechanisms of the association between salt intake and HTN, and highlight the need for customized Chinese practices to reduce salt intake and promote awareness and diet salt reduction strategies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Transportation Science & Technology
Jingke Zhang, Tao Zhu, Bing Yang, Xiaorui Wang, Shoune Xiao, Guangwu Yang, Yanwen Liu, Quanwei Che
Summary: Rail vehicles generate enormous longitudinal impact loads during collisions, and if there is a mismatch between the compressive strength of the intermediate coupler and the structural strength of the car body, the risk of car body damage and train derailment increases. In this study, a four-stage rigid-flexible coupling finite element model of the coupler is established, taking into account the coupler buckling load. The influence of the coupler buckling load on the train's longitudinal-vertical-horizontal buckling behavior is investigated, and the mechanism of horizontal buckling instability in train collisions is revealed.
RAILWAY ENGINEERING SCIENCE
(2023)
Article
Engineering, Mechanical
Shuwei Zhou, Bing Yang, Shoune Xiao, Guangwu Yang, Tao Zhu
Summary: Machine learning has been widely used in the fatigue field, but most methods are difficult to apply in engineering practice. This study introduces symbolic regression as an interpretable method for determining the optimal fatigue crack growth rate model. The results show that the symbolic regression model has higher prediction accuracy compared to traditional semi-empirical models.
CHINESE JOURNAL OF MECHANICAL ENGINEERING
(2023)
Article
Optics
Wang Yu, Xiao Di, Niu Yangyang, Yang Jie, Yang Pengxi, Zhu Zhaohao, Yin Guolu, Zhu Tao
Summary: Objective Fiber optic hydrophones are underwater acoustic sensors that convert sound signals into optical signals for data processing. They have high sensitivity, resistance to electromagnetic radiation, and are suitable for harsh conditions. With the increase in maritime activities, research on hydrophone arrays has become important. However, the probe technology is crucial for the stability and performance of hydrophones. This study proposes a high-precision measurement method based on optical frequency domain reflectometry to monitor the deformation of hydrophone probes.
ACTA OPTICA SINICA
(2023)