Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells
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Title
Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells
Authors
Keywords
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Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 11, Issue 8, Pages 1556-1564
Publisher
Wiley
Online
2013-05-28
DOI
10.1111/jth.12306
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Note: Only part of the references are listed.- A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay
- (2013) A. Fregin et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Polymorphisms in VKORC 1 have more impact than CYP2C9 polymorphisms on early warfarin International Normalized Ratio control and bleeding rates
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- VKORC1mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity
- (2012) A. HODROGE et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- A transcription activator-like effector toolbox for genome engineering
- (2012) Neville E Sanjana et al. Nature Protocols
- TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction
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- Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis
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- Mycobacterium tuberculosis Vitamin K Epoxide Reductase Homologue Supports Vitamin K–Dependent Carboxylation in Mammalian Cells
- (2011) Jian-Ke Tie et al. ANTIOXIDANTS & REDOX SIGNALING
- Functional study of the vitamin K cycle in mammalian cells
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- Role of vitamin K-dependent proteins in the arterial vessel wall
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- Human Vitamin K 2,3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function
- (2011) Philipp Westhofen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- More on: endoplasmic reticulum loop VKORC1 substitutions cause warfarin resistance but do not diminish gamma-carboxylation of the vitamin K-dependent coagulation factors
- (2011) D. J. HARRINGTON et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Vitamin K Antagonists – Current Concepts and Challenges
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- (2009) Peter C. J. Schmeits et al. BRITISH JOURNAL OF HAEMATOLOGY
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- (2009) M. J. Moscou et al. SCIENCE
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- Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans
- (2008) L. BODIN et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
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