High glucose and insulin enhance uPA expression, ROS formation and invasiveness in breast cancer-derived cells

Combined effect of insulin and high glucose concentration on albumin permeability in cultured rat podocytes

(2015) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Glucose Promotes Tumor Invasion and Increases Metastasis-Associated Protein Expression in Human Lung Epithelial Cells by Upregulating Heme Oxygenase-1 via Reactive Oxygen Species or the TGF-β1/PI3K/Akt Signaling Pathway

(2015) Xiaowen Kang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Highly specific role of the insulin receptor in breast cancer progression

(2015) R. Rostoker et al.   ENDOCRINE-RELATED CANCER

Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling

(2015) Oscar Escribano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system

(2015) Kristina Goetze et al.   CELLULAR ONCOLOGY

The Association between Type 2 Diabetes Mellitus and Women Cancer: The Epidemiological Evidences and Putative Mechanisms

(2015) Kyong Hye Joung et al.   Biomed Research International

Diabetes and Its Link with Cancer: Providing the Fuel and Spark to Launch an Aggressive Growth Regime

(2015) Sanket Joshi et al.   Biomed Research International

Procyanidin B2 inhibits high glucose-induced epithelial-mesenchymal transition in HK-2 human renal proximal tubular epithelial cells

(2015) DANDAN LI et al.   Molecular Medicine Reports

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

(2015) Francesca Margheri et al.   Oncotarget

Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions

(2014) Chanchal Gupta et al.   EXPERIMENTAL CELL RESEARCH

PAI-1 Leads to G 1 -Phase Cell-Cycle Progression through Cyclin D3/cdk4/6 Upregulation

(2014) Evan Gomes Giacoia et al.   MOLECULAR CANCER RESEARCH

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells

(2014) Roberta Malaguarnera et al.   Frontiers in Endocrinology

Breast cancer incidence before and after diagnosis of type 2 diabetes mellitus in women

(2013) Adedayo A. Onitilo et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells

(2013) Chanchal Gupta et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer

(2013) Pushpendra Singh et al.   MEDICAL ONCOLOGY

High glucose induces mitochondrial p53 phosphorylation by p38 MAPK in pancreatic RINm5F cells

(2013) Luis A. Flores-López et al.   MOLECULAR BIOLOGY REPORTS

SK-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis

(2013) Takeshi Masuda et al.   MOLECULAR CANCER THERAPEUTICS

The Apparent uPA/PAI-1 Paradox in Cancer: More than Meets the Eye

(2013) Andrew Mazar et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

A Twenty-First Century Cancer Epidemic Caused by Obesity: The Involvement of Insulin, Diabetes, and Insulin-Like Growth Factors

(2013) Rosalyne L. Westley et al.   International Journal of Endocrinology

The urokinase plasminogen activator system in breast cancer invasion and metastasis

(2012) Linlin Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Insulin resistance and cancer: the role of insulin and IGFs

(2012) Sefirin Djiogue et al.   ENDOCRINE-RELATED CANCER

The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression

(2012) David P Rose et al.   ENDOCRINE-RELATED CANCER

Impact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients

(2012) Cynthia Villarreal-Garza et al.   Experimental Diabetes Research

Protumorigenic Activity of Plasminogen Activator Inhibitor-1 Through an Antiapoptotic Function

(2012) Hua Fang et al.   JNCI-Journal of the National Cancer Institute

Breast cancer in Mexico: a growing challenge to health and the health system

(2012) Yanin Chávarri-Guerra et al.   LANCET ONCOLOGY

Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress

(2012) Shiny Abhijit et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Matrix-Bound PAI-1 Supports Cell Blebbing via RhoA/ROCK1 Signaling

(2012) Amandine Cartier-Michaud et al.   PLoS One

Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells

(2012) Pham Ngoc Khoi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel

(2011) Eva J Kantelhardt et al.   BMC CANCER

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2011) Manfred Schmitt et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

(2010) Darren L. Roberts et al.   Annual Review of Medicine

Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

(2010) Masahiro Uchino et al.   BMC CANCER

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation

(2010) K Masur et al.   BRITISH JOURNAL OF CANCER

Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR

(2010) Takashi Watanabe et al.   Cancer Cell International

UPA and PAI-1 Analysis from Fixed Tissues – New Perspectives for a Known Set of Predictive Markers

(2010) K. Malinowsky et al.   CURRENT MEDICINAL CHEMISTRY

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer

(2010) B. Märkl et al.   JOURNAL OF SURGICAL ONCOLOGY

Regulation of proteinases during mouse peri-implantation development: urokinase-type plasminogen activator expression and cross talk with matrix metalloproteinase 9

(2010) M G Martínez-Hernández et al.   REPRODUCTION

Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells

(2009) Aamir Ahmad et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells

(2009) Kyung Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Insulin Acts through FOXO3a to Activate Transcription of Plasminogen Activator Inhibitor Type 1

(2009) Ushma R. Jag et al.   MOLECULAR ENDOCRINOLOGY