Journal
CATALYSIS SCIENCE & TECHNOLOGY
Volume 6, Issue 12, Pages 4398-4409Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cy02142a
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Funding
- Spanish MINECO [CTQ2013-40591-P, CTQ2014-51912-REDC]
- Gobierno del Principado de Asturias [GRUPIN14-006]
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The catalytic hydration of nitriles into amides, in water under neutral conditions, has been studied using a series of arene-ruthenium(II) complexes containing commercially available chlorophosphines as auxiliary ligands, i.e. compounds [RuCl2(eta(6)-p-cymene)(PR2Cl)] (R = aryl, heteroaryl or alkyl group). In the reaction medium, the coordinated chlorophosphines readily undergo hydrolysis to generate the corresponding phosphinous acids PR2OH, which are well-known cooperative ligands for this catalytic transformation. Among the complexes employed, best results were obtained with [RuCl2(eta(6)-p-cymene){P(4-C6H4F)(2)Cl}]. Performing the catalytic reactions at 40 degrees C with 2 mol% of this complex, a large variety of organonitriles could be selectively converted into the corresponding primary amides in high yields and relatively short times. The application of [RuCl2(eta(6)-p-cymene){P(4-C6H4F)(2)Cl}] in the preparation of synthetically useful beta-ketoamides is also presented.
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