Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias

(2015) Remi Favier et al.   BRITISH JOURNAL OF HAEMATOLOGY

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

(2015) Satoshi Nishimura et al.   JOURNAL OF CELL BIOLOGY

Magnesium and cardiovascular complications of chronic kidney disease

(2015) Ziad A. Massy et al.   Nature Reviews Nephrology

Post-translational modifications of tubulin: pathways to functional diversity of microtubules

(2015) Yuyu Song et al.   TRENDS IN CELL BIOLOGY

Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders

(2015) Sarah K Westbury et al.   Genome Medicine

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

(2014) K. R. Spinler et al.   BLOOD

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

(2014) M. Meinders et al.   BLOOD

Function and regulation of the channel-kinase TRPM7 in health and disease

(2014) Daan Visser et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Magnesium Modulates Actin Binding and ADP Release in Myosin Motors

(2014) Anja M. Swenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

(2014) Renata Grozovsky et al.   NATURE MEDICINE

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

(2014) A. P. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect

(2014) Markus Bender et al.   Nature Communications

Inactivation of TRPM7 kinase activity does not impair its channel function in mice

(2014) Taku Kaitsuka et al.   Scientific Reports

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

Timing of Myocardial Trpm7 Deletion During Cardiogenesis Variably Disrupts Adult Ventricular Function, Conduction, and Repolarization

(2013) Rajan Sah et al.   CIRCULATION

Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain

(2013) A. Guilbert et al.   EUROPEAN JOURNAL OF CANCER

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition

(2013) Y. Chen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

TRPM7 Is Required for Breast Tumor Cell Metastasis

(2012) Jeroen Middelbeek et al.   CANCER RESEARCH

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

(2012) Lin Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

TRPM7 regulates polarized cell movements

(2011) Li-Ting Su et al.   BIOCHEMICAL JOURNAL

The Mg2+transporter MagT1 partially rescues cell growth and Mg2+uptake in cells lacking the channel-kinase TRPM7

(2011) Francina Deason-Towne et al.   FEBS LETTERS

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes

(2011) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM7 regulates gastrulation during vertebrate embryogenesis

(2010) Wei Liu et al.   DEVELOPMENTAL BIOLOGY

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor

(2009) Elie Abed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MYH9-Related Platelet Disorders

(2009) Karina Althaus et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

TRPM7 Regulates Myosin IIA Filament Stability and Protein Localization by Heavy Chain Phosphorylation

(2008) Kristopher Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE