Article
Immunology
Eduard Schulz, Isabel Hodl, Patrick Forstner, Stefan Hatzl, Nazanin Sareban, Martina Moritz, Johannes Fessler, Barbara Dreo, Barbara Uhl, Claudia Url, Andrea J. Grisold, Michael Khalil, Barbara Kleinhappl, Christian Enzinger, Martin H. Stradner, Hildegard T. Greinix, Peter Schlenke, Ivo Steinmetz
Summary: In immunocompromised patients, the number of naive B cells correlates strongly with antibody levels post COVID-19 vaccination, serving as the key predictor for achieving a humoral response comparable to healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sujin Lee, Jeong In Yang, Joo Hee Lee, Hyun Woo Lee, Tae Jin Kim
Summary: This study identifies naturally occurring anergic B cells in normal mice characterized by low-level expression of CD138, downregulation of IgM, reduced Ca2+ and CD69 responses upon BCR engagement, and distinct BCR repertoire.
Article
Biotechnology & Applied Microbiology
Lin Sun, Chengmin Sun, Shibo Zhou, Lan Zhang, Wenping Hu
Summary: Studies have shown that tamsulosin can reduce the damage to glomerular endothelial cells caused by high glucose by decreasing inflammatory and oxidative stress responses. By regulating the expression of various cytokines and molecules, tamsulosin may have the potential to be a treatment for diabetic nephropathy.
Article
Immunology
Liting Wu, Yanjian Yang, Along Gao, Jun Li, Jianmin Ye
Summary: The study found that tilapia anterior kidney (AK) leukocytes can be divided into two subsets of IgM(+) B cells: lymphoid (L) gate and granulocyte-monocyte/macrophage (G-M) subsets. The G-M gate IgM(+) cells resemble plasma-like cells, with high antibody-secreting, phagocytic, and antigen-presenting capacities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chin Wai Hui, Wai Chung Wu, Shui On Leung
Summary: This study reveals the differential roles of IL-4 and IL-21 in promoting survival of hyperactivated B cells, providing insights for the treatment of autoimmune diseases. IL-4 directly suppresses caspase 3 activation and DNA damage, while IL-21 induces B cell proliferation in the presence of anti-IgM and inhibits activation-induced cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
M. Christian Tjiam, Sonia Fernandez, Martyn A. French
Summary: The study investigates the antigen-specific B cell response to tetanus toxoid booster vaccination in humans. It reveals the diverse responses of B cell subsets and their association with activated circulating follicular helper T cells, providing important insights for vaccine design.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Antonio Di Sabatino
Summary: IgM memory B cells may play a protective role against COVID-19 and other coronaviruses in the acute phase of infection, but further research is needed. Early detection of impaired IgM memory B cell response in patients can improve care and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Taruna Gupta, Harpreet Kaur, Suman Kapila, Rajeev Kapila
Summary: Probiotic Lacticaseibacillus rhamnosus has the potential to prevent gastrointestinal disorders by modulating the immune response and countering inflammatory cytokine expression during exclusion of Escherichia coli in intestinal cells.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zachary C. Stensland, John C. Cambier, Mia J. Smith
Summary: Targeted therapies focusing on autoantigen-specific B cells have shown potential for more precise treatment of autoimmune disorders, while also presenting challenges that need to be addressed for their clinical applicability.
Article
Pharmacology & Pharmacy
Qingman He, Kanghua Fu, Huan Yao, Shujun Wei, Li Xiang, Sixian Liu, Tao Chen, Yongxiang Gao
Summary: This study found that Si Zhi Wan (SZW) has a therapeutic effect on osteoporosis induced by ovariectomy. SZW inhibited the formation of osteoclasts and attenuated osteoclast-mediated bone resorption in both in vitro and in vivo experiments. It also promoted apoptosis of mature osteoclasts. Mechanistically, SZW exerted its effects by suppressing the NF-kappa B pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Olivia Kugler-Umana, Wenliang Zhang, Yi Kuang, Jialing Liang, Catherine H. Castonguay, Susan L. Tonkonogy, Ann Marshak-Rothstein, Priyadharshini Devarajan, Susan L. Swain
Summary: This study found that the response to influenza A virus infection in aged mice is dominated by a specific population of B cells called infection-induced ABC (iABC). These iABC can produce neutralizing antibodies. Additionally, the study found that immunization with whole inactivated virus in aged mice also generates iABC. Therefore, IgD(+)ABC is likely to play a role as primary B cells that secrete antibodies and provide protection from infection in the aged.
Article
Plant Sciences
Dong Zhen, Tian-qi Xuan, Boqin Hu, Xue Bai, Dan-ni Fu, Yu Wang, Yun Wu, Jingfeng Yang, Qianqian Ma
Summary: Pteryxin has anti-inflammatory properties by inhibiting NF-kappa B/MAPK signaling pathway and blocking NLRP3 activation, suggesting it as a potential treatment option for inflammatory-related diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Veterinary Sciences
Mengyue Tian, Ke Li, Ruonan Liu, Jinliang Du, Dongmin Zou, Yuzhong Ma
Summary: The study demonstrated that Angelica polysaccharide (AP) can reduce inflammatory mediators production in dairy cow claw dermal cells, regulate the expression of TLR4, MyD88, and chemokines, and inhibit NF-kappa B and MAPK signaling pathways activation.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juewon Kim, Jeongin Lee, Hyunjung Choi
Summary: The study found that intense pulsed light (IPL) treatment helps alleviate the photoaged phenotype of skin cells induced by UVB, reducing excessive cutaneous immune reactions by suppressing proinflammatory cytokine expression. Combined treatment with green and yellow IPL synergistically attenuates hyperpigmentation and excessive immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yongxian Li, Sipeng Lin, Panjie Liu, Jianbin Huang, Junxiong Qiu, Zhenkang Wen, Jinbo Yuan, Heng Qiu, Yuhao Liu, Qian Liu, Tengpeng Zhou, Peijie Luo, Huizhi Guo, Yanhuai Ma, Danqing Guo, Guoye Mo, Yongchao Tang, Liangliang Xu, De Liang, Jiake Xu, Yue Ding, Shuncong Zhang
Summary: The study found that Carnosol has a strong inhibitory effect on osteoclast differentiation induced by RANKL, potentially serving as a therapeutic supplementary in the prevention or treatment of osteolysis by suppressing the formation and function of RANKL-induced osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Joanne H. Reed
Summary: Autoimmune diseases are characterized by the presence of serum autoantibodies, which can be pathogenic and cause severe manifestations and organ injury. The development of these autoantibodies is driven by various genetic and environmental factors, but the factors behind the development of pathogenic autoantibodies are not well understood. Recent advancements in single-cell technology have allowed for the analysis of rare B cell clones producing pathogenic autoantibodies, revealing genetic events and mutations that disrupt antibody quality control mechanisms and decrease autoantibody solubility. Understanding the molecular characteristics and tolerance checkpoints involved in the formation of these pathogenic autoantibodies will improve prognostication, enabling early treatment to prevent organ damage and B cell malignancy.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Education & Educational Research
Yeshe Colliver, Linda J. Harrison, Judith E. Brown, Peter Humburg
Summary: Self-regulation skills are crucial for successful participation in society, and early exposure to unstructured play activities can predict future self-regulation abilities. This study used a large sample to investigate the relationship between play time and self-regulation in children, finding that more time spent in unstructured play during early childhood was associated with better self-regulation abilities.
EARLY CHILDHOOD RESEARCH QUARTERLY
(2022)
Article
Anesthesiology
Luke C. Jenkins, Wei-Ju Chang, Valentina Buscemi, Matthew Liston, Peter Humburg, Michael Nicholas, Thomas Graven-Nielsen, Paul W. Hodges, James H. McAuley, Siobhan M. Schabrun
Summary: This study aims to identify neurobiological and psychological risk factors for the development of chronic low back pain. Factors such as medical history, age, and emotional state have a significant impact on the development of chronic low back pain. Neurobiological risk factors explain an additional 15% of the variance in pain intensity at 6 months.
Article
Clinical Neurology
Lauriane Juge, Fiona L. Knapman, Peter Humburg, Peter G. R. Burke, Aimee B. Lowth, Elizabeth Brown, Jane E. Butler, Danny J. Eckert, Joachim Ngiam, Kate Sutherland, Peter A. Cistulli, Lynne E. Bilston
Summary: This study aimed to investigate how mandibular advancement enlarges the upper airway via posterior tongue advancement in people with obstructive sleep apnea (OSA), and whether this is associated with mandibular advancement splint (MAS) treatment outcome. The results showed that responders had the greatest tongue and upper airway movements, which indicated a satisfactory treatment response to MAS.
Article
Biochemistry & Molecular Biology
Zainab Khudhair, Rafid Alhallaf, Ramon M. Eichenberger, Matt Field, Lutz Krause, Javier Sotillo, Alex Loukas
Summary: The gastrointestinal helminth Nippostrongylus brasiliensis has therapeutic potential for treating metabolic syndrome and type 2 diabetes (T2D) by modulating the immune response and gut microbiota composition.
Article
Anesthesiology
Wei-Ju Chang, Luke C. C. Jenkins, Peter Humburg, Siobhan M. M. Schabrun
Summary: This study found that central sensitization is present in some patients with acute low back pain, but it is not related to pain or disability. There is no relationship between BDNF and central sensitization in acute low back pain. Variation in sensory measures during acute low back pain can be partially explained by BDNF genotype, sex, age, and psychological factors.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Immunology
Oriol Fornes, Alicia Jia, Hye Sun Kuehn, Qing Min, Ulrich Pannicke, Nikolai Schleussner, Romane Thouenon, Zhijia Yu, Maria de los Angeles Astbury, Catherine M. Biggs, Miguel Galicchio, Jorge Alberto Garcia-Campos, Silvina Gismondi, Guadalupe Gonzalez Villarreal, Kyla J. Hildebrandt, Manfred Honig, Jia Hou, Despina Moshous, Stefania Pittaluga, Xiaowen Qian, Jacob Rozmus, Ansgar S. Schulz, Aide Tamara Staines-Boone, Bijun Sun, Jinqiao Sun, Schauer Uwe, Edna Venegas-Montoya, Wenjie Wang, Xiaochuan Wang, Wenjing Ying, Xiaowen Zhai, Qinhua Zhou, Altuna Akalin, Isabelle Andre, Thomas F. E. Barth, Bernd Baumann, Anne Brustle, Gaetan Burgio, Jacinta C. Bustamante, Jean-Laurent Casanova, Marco G. Casarotto, Marina Cavazzana, Loic Chentout, Ian A. Cockburn, Mariantonia Costanza, Chaoqun Cui, Oliver Daumke, Kate L. Del Bel, Hermann Eibel, Xiaoqian Feng, Vedran Franke, J. Christof M. Gebhardt, Andrea Goetz, Stephan Grunwald, Benedicte Hoareau, Timothy R. Hughes, Eva-Maria Jacobsens, Martin Janz, Arttu Jalma, Chantal Lagresle-Peyrou, Nannan Lai, Yaxuan Li, Susan Lin, Henry Y. Lu, Saul O. Lugo-Reyes, Xin Meng, Pete Moeller, Nidia Moreno-Corona, Julie E. Niemela, Gherman Novakovsky, Jareb J. Perez-Caraballo, Capucine Picard, Lucie Poggi, Maria-Emilia Puig-Lombardi, Katrina L. Randallr, Anja Reisser, Yohann Schmitt, Sandali Seneviratne, Mehul Sharma, Jennifer Stoddard, Srinivasan Sundararaj, Harry Sutton, Linh Q. Tran, Ying Wang, Wyeth W. Wasserman, Zichao Wen, Wiebke Winkler, Ermeng Xiong, Ally W. H. Yang, Meiping Yu, Lumin Zhang, Hai Zhang, Qian Zhao, Xin Zhen, Anselm Enders, Sven Kracker, Ruben Martinez-Barricarte, Stephan Mathas, Sergio D. Rosenzweig, Klaus Schwarz, Stuart E. Turvey, Ji-Yang Wang
Summary: A recurrent heterozygous mutation in IRF4 has been found to cause autosomal dominant combined immunodeficiency. This mutation leads to severe susceptibility to opportunistic infections, including Pneumocystis jirovecii, and agamma-globulinemia. The pathophysiology of this mutation disrupts normal lymphocyte biology through multimorphic changes in the function of IRF4.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Mehmet Yabas, Ayten Bostanci, Seda Aral
Summary: P4-type ATPases contribute to the asymmetrical distribution of aminophospholipids on plasma membranes in eukaryotes. However, their roles in the immune system are not well understood. By studying ATP11C-deficient pre-B cells, it was found that ATP11C is important for the flippase activity and differentiation of pre-B cells, but not their proliferation in response to IL-7. These findings suggest that ATP11C-mediated lipid asymmetry controls the switch from proliferation to differentiation in pre-B cells.
IMMUNOLOGIC RESEARCH
(2023)
Article
Psychology, Clinical
Thanwarat Chantanachai, Daina L. Sturnieks, Stephen R. Lord, Jasmine Menant, Kim Delbaere, Perminder S. Sachdev, Henry Brodaty, Peter Humburg, Morag E. Taylor
Summary: This study examined longitudinal changes in cognitive and physical function, as well as the associations between these changes and falls in people with and without mild cognitive impairment (MCI). The results showed that the MCI and cognitively fluctuating groups experienced declines in cognitive function, while the cognitively normal group did not. The MCI group had worse physical function at baseline but similar decline over time compared to other groups. Decline in global cognitive function and sensorimotor performance were associated with multiple falls in the cognitively normal group, and decline in mobility was associated with falls in the entire sample. Therefore, exercise should be recommended for maintaining physical function in older adults, and interventions aimed at mitigating cognitive decline should be encouraged for people with MCI.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Engineering, Biomedical
Jun Cao, Iain Ball, Peter Humburg, Socrates Dokos, Caroline Rae
Summary: Magnetic resonance electrical properties tomography (MREPT) is a promising imaging technique for noninvasively measuring tissue conductivity and permittivity. This study investigated the repeatability of conductivity measurements using phase-based MREPT and the impact of compressed SENSE (CS) and RF shimming on measurement precision. The results showed that conductivity measurements using CS with bFFE phase were more repeatable and precise than those using TSE. RF shimming with better field mapping further improved the precision of the conductivity measures.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Wei-Ju Chang, Luke C. Jenkins, Peter Humburg, Valerie Wasinger, David M. Walton, Siobhan M. Schabrun
Summary: The study aimed to investigate the changes in pro- and anti-inflammatory molecules in patients with acute low back pain (LBP) and their association with long-term outcome. The results showed that the concentrations of systemic inflammatory molecules remained unchanged over a period of six months, regardless of recovery status. At three months, the unrecovered group had higher levels of IL-8 and IL-10 compared to the recovered group. Acute-stage psychological factors were not related to systemic inflammatory molecules. Further research is needed to understand the contribution of these molecules to long-term LBP outcome.
Article
Clinical Neurology
Euan J. Mccaughey, Frederick K. Ho, Daniel F. Mackay, Jill P. Pell, Peter Humburg, Mariel Purcell
Summary: This study found that traumatic spinal cord injury (TSCI) incidence in Scotland decreased during COVID-19 lockdowns, potentially due to reduced engagement in risky activities. However, TSCI cases caused by deliberate self-harm increased, reflecting mental health problems and social isolation. The findings highlight the economic impact and temporary reduction in healthcare burden during the pandemic.
Article
Multidisciplinary Sciences
Doris R. Pierce, Malcolm McDonald, Lea Merone, Luke Becker, Fintan Thompson, Chris Lewis, Rachael Y. M. Ryan, Sze Fui Hii, Patsy A. Zendejas-Heredia, Rebecca J. Traub, Matthew A. Field, Tony Rahman, John Croese, Alex Loukas, Robyn McDermott, Paul R. Giacomin
Summary: This study demonstrates that treatment with hookworms is safe and can improve metabolic health in people at risk of type 2 diabetes. The findings suggest a potential protective role for parasitic worms against metabolic disorders, although further research is needed.
NATURE COMMUNICATIONS
(2023)
Article
Biology
J. William O. Ballard, Matt A. Field, Richard J. Edwards, Laura A. B. Wilson, Loukas G. Koungoulos, Benjamin D. Rosen, Barry Chernoff, Olga Dudchenko, Arina Omer, Jens Keilwagen, Ksenia Skvortsova, Ozren Bogdanovic, Eva Chan, Robert Zammit, Vanessa Hayes, Erez Lieberman Aiden
Summary: We describe a female Alpine dingo named Cooinda, who has been identified as a representative specimen for future research on the evolutionary history, morphology, physiology, and ecology of dingoes. The study provides evidence that Cooinda exhibits genetic and morphological characteristics typical of the Alpine ecotype.
Review
Biochemistry & Molecular Biology
Rhys Gillman, Matt A. Field, Ulf Schmitz, Rozemary Karamatic, Lionel Hebbard
Summary: Cancer, a heterogeneous disease with a strong genetic component, can benefit from precision medicine approaches to identify molecular drivers. Single-tumour methods based on gene interaction networks have limitations and require further research for evaluation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
