Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

(2016) Andrew E Teschendorff et al.   Nature Communications

Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

(2015) Y. Sawai et al.   CANCER RESEARCH

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

(2015) Paz Polak et al.   NATURE

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

(2015) Pilar M. Dominguez et al.   Cell Reports

BRCA1 185delAG Mutation Enhances Interleukin-1βExpression in Ovarian Surface Epithelial Cells

(2015) Kamisha T. Woolery et al.   Biomed Research International

Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women’s Cancers

(2015) Thomas E. Bartlett et al.   PLoS One

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Glucocorticoid-Induced Reversal of Interleukin-1β-Stimulated Inflammatory Gene Expression in Human Oviductal Cells

(2014) Stéphanie Backman et al.   PLoS One

"The Race" to Clone BRCA1

(2014) M.-C. King   SCIENCE

Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention

(2014) F. J. Couch et al.   SCIENCE

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

(2014) Shahzia Anjum et al.   Genome Medicine

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

(2013) Ruth Perets et al.   CANCER CELL

BRCA1 is a negative modulator of the PRC2 complex

(2013) Lan Wang et al.   EMBO JOURNAL

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study

(2013) Martin Widschwendter et al.   LANCET ONCOLOGY

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes

(2013) Ritu Kumar et al.   NATURE

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

(2012) N. Mavaddat et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4

(2012) C. Auvray et al.   HAEMATOLOGICA

Primary culture and immortalization of human fallopian tube secretory epithelial cells

(2012) Alison M Karst et al.   Nature Protocols

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

(2009) Seok-Rae Park et al.   NATURE IMMUNOLOGY

A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations

(2008) Ann K. Folkins et al.   GYNECOLOGIC ONCOLOGY