The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

A dual-targeted aminoacyl-tRNA synthetase inPlasmodium falciparumcharges cytosolic and apicoplast tRNACys

(2014) James S. Pham et al.   BIOCHEMICAL JOURNAL

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

(2013) Jonghyeon Son et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Using Genetic Methods To Define the Targets of Compounds with Antimalarial Activity

(2013) Erika L. Flannery et al.   JOURNAL OF MEDICINAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

(2013) K. K. Hanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Rapid, Field-Deployable Method for Genotyping and Discovery of Single-Nucleotide Polymorphisms Associated with Drug Resistance in Plasmodium falciparum

(2012) Rachel Daniels et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

Characterization of Plasmodium Liver Stage Inhibition by Halofuginone

(2012) Emily R. Derbyshire et al.   ChemMedChem

Fission yeast TORC1 prevents eIF2  phosphorylation in response to nitrogen and amino acids via Gcn2 kinase

(2012) N. Valbuena et al.   JOURNAL OF CELL SCIENCE

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

(2012) Huihao Zhou et al.   NATURE

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology

(2012) De-Fu Zhang et al.   PARASITOLOGY RESEARCH

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

(2011) Yong-Kang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

(2011) Katherine E. Jackson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Validation of isoleucine utilization targets in Plasmodium falciparum

(2011) E. S. Istvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein translation in Plasmodium parasites

(2011) Katherine E. Jackson et al.   TRENDS IN PARASITOLOGY

Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves

(2011) L. A. Trotz-Williams et al.   VETERINARY RECORD

Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum

(2011) Sameena Khan et al.   Scientific Reports

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

On the inhibition of histone deacetylase 8

(2010) Guillermina Estiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum

(2010) Tarun Bhatt et al.   BMC GENOMICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

(2009) Clare Fennell et al.   MALARIA JOURNAL

Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

(2009) Ivo H. J. Ploemen et al.   PLoS One

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

(2009) M. S. Sundrud et al.   SCIENCE

East meets West: how China almost cured malaria

(2008) William R. Burns   ENDEAVOUR

Translation Regulation by Eukaryotic Initiation Factor-2 Kinases in the Development of Latent Cysts inToxoplasma gondii

(2008) Jana Narasimhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH