Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

(2015) Fadzai Chinyengetere et al.   BMC CANCER

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

(2015) Young Joo Jeon et al.   CANCER CELL

Oncogene-mediated regulation of p53 ISGylation and functions

(2015) Yi-Fu Huang et al.   Oncotarget

Isg15 controls p53 stability and functions

(2014) Yi-Fu Huang et al.   CELL CYCLE

Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections

(2014) S M Dauphinee et al.   GENES AND IMMUNITY

Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis

(2014) Jung Mi Park et al.   MOLECULAR CELL

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target

(2013) Mohammad Shahidul Makki et al.   EXPERIMENTAL CELL RESEARCH

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

(2012) Seong Won Lee et al.   EMBO JOURNAL

Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15

(2012) Young Joo Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target

(2012) Y. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

ISG15 and immune diseases

(2010) Young Joo Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RAR  and Inhibits the Growth of Acute Promyelocytic Leukemia

(2010) Y. Guo et al.   CANCER RESEARCH

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis

(2009) Eun-Woo Lee et al.   EMBO JOURNAL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Expression, regulation and function of the ISGylation system in prostate cancer

(2009) A Kiessling et al.   ONCOGENE

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

UBE1L causes lung cancer growth suppression by targeting cyclin D1

(2008) Q. Feng et al.   MOLECULAR CANCER THERAPEUTICS

UBE1L represses PML/RAR  by targeting the PML domain for ISG15ylation

(2008) S. J. Shah et al.   MOLECULAR CANCER THERAPEUTICS

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY