EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Determining the geometry of oligomers of the human epidermal growth factor family on cells with

(2015) Sarah R. Needham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nanometric molecular separation measurements by single molecule photobleaching

(2015) Stephen E.D. Webb et al.   METHODS

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   MOLECULAR AND CELLULAR BIOLOGY

Keeping EGFR signaling in check

(2014) Simona Polo et al.   CELL CYCLE

Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

(2014) Ye Wang et al.   CELL RESEARCH

Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation

(2014) Jennifer L. Macdonald-Obermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor

(2014) Nicholas J. Bessman et al.   Cell Reports

Coarse-Grained Molecular Simulation of Epidermal Growth Factor Receptor Protein Tyrosine Kinase Multi-Site Self-Phosphorylation

(2014) John G. Koland   PLoS Computational Biology

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis

(2013) A. Fortian et al.   JOURNAL OF CELL SCIENCE

Accurate and efficient integration for molecular dynamics simulations at constant temperature and pressure

(2013) Ross A. Lippert et al.   JOURNAL OF CHEMICAL PHYSICS

Forcefield_PTM: Ab Initio Charge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational Modifications

(2013) George A. Khoury et al.   Journal of Chemical Theory and Computation

Exploring higher-order EGFR oligomerisation and phosphorylation—a combined experimental and theoretical approach

(2013) Noga Kozer et al.   Molecular BioSystems

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Measuring EGFR Separations on Cells with ∼10 nm Resolution via Fluorophore Localization Imaging with Photobleaching

(2013) Sarah R. Needham et al.   PLoS One

Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers

(2013) S. O. Yesylevskyy et al.   TheScientificWorldJOURNAL

Temporal Resolution of Autophosphorylation for Normal and Oncogenic Forms of EGFR and Differential Effects of Gefitinib

(2012) Youngjoo Kim et al.   BIOCHEMISTRY

A toolkit and benchmark study for FRET-restrained high-precision structural modeling

(2012) Stanislav Kalinin et al.   NATURE METHODS

A Switch Role of Src in the Biphasic EGF Signaling of ER-Negative Breast Cancer Cells

(2012) XinTian Zhang et al.   PLoS One

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimal Model of Plasma Membrane Heterogeneity Requires Coupling Cortical Actin to Criticality

(2011) Benjamin B. Machta et al.   BIOPHYSICAL JOURNAL

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

(2011) Rob C. Roovers et al.   INTERNATIONAL JOURNAL OF CANCER

Human Epidermal Growth Factor Receptor (EGFR) Aligned on the Plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry

(2011) C. J. Tynan et al.   MOLECULAR AND CELLULAR BIOLOGY

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways

(2011) Jordan A. Krall et al.   PLoS One

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes

(2010) Qiong L. Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Palmitoylation of the EGF Receptor Impairs Signal Transduction and Abolishes High-Affinity Ligand Binding†

(2009) Jennifer L. Macdonald-Obermann et al.   BIOCHEMISTRY

Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots

(2009) J. Z. Rappoport et al.   JOURNAL OF CELL SCIENCE

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network

(2008) Sandra Morandell et al.   PROTEOMICS