Review
Biotechnology & Applied Microbiology
Mallory K. Ellingson, Hassan Sheikha, Kate Nyhan, Carlos R. Oliveira, Linda M. Niccolai
Summary: Human papillomavirus (HPV) vaccines are most effective when administered at younger ages, preventing infections prior to natural exposure. A systematic review of HPV vaccine effectiveness studies published between 2007 and 2022 found that the highest vaccine effectiveness was observed in the youngest age group. Vaccine effectiveness estimates ranged from approximately 74% to 93% for younger adolescents ages 9-14 years and from 12% to 90% for adolescents ages 15-18 years. These findings emphasize the importance of on-time vaccination for optimal protection against HPV-related diseases.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Denny Fe Agana-Norman, Abbey B. Berenson, Mihyun Chang
Summary: The uptake of the HPV vaccine in the US was initially low, especially among adolescent males. To address this issue, the CDC partnered with a communications development company to launch a national campaign. Research shows that this campaign had a positive impact on improving HPV vaccine uptake among adolescent males.
PREVENTIVE MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
Mugen Ujiie, Taito Kitano, Shinya Tsuzuki
Summary: Despite the suspension of the HPV vaccine recommendation by the Japanese Ministry of Health, there has been a significant increase in the number of vaccines delivered to healthcare facilities, likely due to government efforts to convey information about the HPV vaccination and ongoing local educational programs. The incidence of reported adverse events per vaccine dose has not increased since 2016.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Li Dong, Mari Nygard, Nathalie C. Stoer, Ole Klungsoyr, Bo T. Hansen
Summary: This study conducted in Norway presents the first real-world effectiveness study of HPV vaccination on high-grade cervical lesions outside the routine program. The findings indicate that HPV vaccination is effective against high-grade cervical lesions among women vaccinated below age 20, but may not have the desired impact among women vaccinated at age 20 or older.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
John D. Seeger, Kandace L. Amend, Bruce R. Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier
Summary: This study assessed the risk of new onset autoimmune conditions among males receiving the 4-valent human papillomavirus (HPV) vaccine (4vHPV), and the results showed that the incidence of autoimmune conditions among vaccinated males was similar to that among unvaccinated males.
Article
Immunology
Anyie J. Li, Fatuma Manzi, Furaha Kyesi, Yusuf Makame, William Mwengee, Monica Fleming, Abdallah Mkopi, Selemani Mmbaga, Dafrossa Lyimo, Anagha Loharikar
Summary: The HPV vaccination program in Tanzania was well accepted by community stakeholders in 18 councils, with adequate knowledge demonstrated by health workers and school personnel. However, continued technical support for integrating the vaccine into routine immunization activities and reinforcing basic knowledge about the vaccine in specific community groups is needed.
Letter
Medicine, General & Internal
Didem Egemen, Hormuzd A. Katki, Anil K. Chaturvedi, Rebecca Landy, Li C. Cheung
Summary: This survey study examined the self-reported status and timing of HPV vaccination among female participants in the National Health and Nutrition Examination Survey from 2011 to 2018.
Article
Biotechnology & Applied Microbiology
Kandace L. Amend, Bruce Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier, John D. Seeger
Summary: This study assesses the safety of the 4-valent HPV vaccine in males and finds associations with same-day allergic reactions, ear infections, intracranial injury, cellulitis, and concussion. However, other adverse outcomes are determined to be more likely related to activities common in adolescent males rather than the vaccination itself.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
Catharine Chambers, Shelley L. Deeks, Rinku Sutradhar, Joseph Cox, Alexandra de Pokomandy, Troy Grennan, Trevor A. Hart, Gilles Lambert, David M. Moore, Daniel Grace, Ramandip Grewal, Jody Jollimore, Nathan J. Lachowsky, Ashley Mah, Rosane Nisenbaum, Gina Ogilvie, Chantal Sauvageau, Darrell H. S. Tan, Anna Yeung, Ann N. Burchell
Summary: Self-reported human papillomavirus (HPV) vaccination has limitations in terms of accuracy. This study investigated the impact of misclassification associated with self-reported vaccination on the estimates of vaccine effectiveness (VE). The results showed that bias-corrected VE estimates were relatively stable across different sensitivity values, but differed from the uncorrected estimate at lower specificity values. The study concluded that a large proportion of participants would need to erroneously report HPV vaccination in order to significantly change VE estimates.
Article
Pharmacology & Pharmacy
Steven Simoens, Andre Bento-Abreu, Barbara Merckx, Sophie Joubert, Steve Vermeersch, Andrew Pavelyev, Stefan Varga, Edith Morais
Summary: Expanding HPV vaccination programs in Belgium to gender-neutral vaccination (GNV) with the 9-valent HPV vaccine can reduce the burden of HPV-related disease and deaths, and is cost-effective compared to female-only vaccination (FOV).
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Sunny Jung Kim, Jenna E. Schiffelbein, Inger Imset, Ardis L. Olson
Summary: This study found that evidence-based messages in social media can effectively change parents' attitudes and behavioral intentions towards HPV vaccination. Messages that provide scientific evidence and correct misinformation are particularly effective in promoting positive perceptions of the HPV vaccine.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Supitcha Kamolratanakul, Punnee Pitisuttithum
Summary: Human papillomavirus (HPV) is the most common sexually transmitted infection, with 15 HPV types related to various cancers. HPV vaccines have been proven to be safe and highly effective in preventing HPV infections and associated cancers, especially among young women. The different types of HPV vaccines have shown similar efficacy in protecting against certain HPV types, with the nonavalent vaccine offering additional protection against more types. HPV vaccination has also been shown to provide herd protection and reduce the prevalence of HPV-related cancers.
Review
Public, Environmental & Occupational Health
Hyunjeong Shin, Songi Jeon, Inhae Cho, HyunJi Park
Summary: This review identified factors affecting HPV vaccine initiation in men, including sociodemographic factors, belief-related variables, family factors, community factors, variables related to needs, and environmental factors. Strategies targeting young males and their families, such as frequent visits to or contact with health care providers, should be implemented to increase HPV vaccination rates in men.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Immunology
Lore Merdrignac, Lesly Acosta, Adele Habington, Manuel Garcia Cenoz, Elisabetta Pandolfi, Katerina Fabianova, Iolanda Jordan, Niam O'Sullivan, Ana Navasues, Alberto E. Tozzi, Jana Zavadilova, Mireia Jane, Suzanne Cotter, Nerea Pitillas, Caterina Rizzo, Pavla Krizova, Thomas Hanslik, Carmen Munoz Almagro, Lucia Pastore, Sabrina Bacci, Alain Moren, Marta Valenciano
Summary: This study investigated the effectiveness of pertussis vaccination during pregnancy and the effectiveness of infant vaccination against pertussis. The results showed that vaccination during pregnancy can reduce the risk of pertussis infection in infants.
Article
Obstetrics & Gynecology
C. Acuti Martellucci, S. Nomura, D. Yoneoka, P. Ueda, J. M. L. Brotherton, K. Canfell, M. Palmer, L. Manzoli, P. Giorgi Rossi, A. De Togni, C. Palmonari, A. Califano, E. Saito, M. Hashizume, K. Shibuya
Summary: This retrospective cohort study in Italy assessed the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities detected during subsequent screenings. Results showed that women who received at least one dose of the HPV vaccine were significantly less likely to have abnormal cervical cytology. Overall, catch-up HPV vaccination almost halved the risk of cytological abnormalities in organized cervical screening programmes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Infectious Diseases
Isobel Mary Poynten, Dorothy Machalek, David Templeton, Fengyi Jin, Richard Hillman, Iryna Zablotzska, Garrett Prestage, Martin Holt, Andrew Grulich
SEXUALLY TRANSMITTED INFECTIONS
(2016)
Article
Oncology
Jennifer M. Roberts, Fengyi Jin, Julia K. Thurloe, Deborah Ekman, Marjorie K. Adams, Ross L. McDonald, Clare Biro, I. Mary Poynten, Andrew E. Grulich, Annabelle Farnsworth
CANCER CYTOPATHOLOGY
(2016)
Article
Health Care Sciences & Services
Roopa Das, Dorothy A. Machalek, Edmund G. Molesworth, Suzanne M. Garland
JOURNAL OF MEDICAL INTERNET RESEARCH
(2017)
Article
Infectious Diseases
Eric P. F. Chow, Dorothy A. Machalek, Sepehr N. Tabrizi, Jennifer A. Danielewski, Glenda Fehler, Catriona S. Bradshaw, Suzanne M. Garland, Marcus Y. Chen, Christopher K. Fairley
LANCET INFECTIOUS DISEASES
(2017)
Article
Multidisciplinary Sciences
Monica Molano, Sepehr N. Tabrizi, Suzanne M. Garland, Jennifer M. Roberts, Dorothy A. Machalek, Samuel Phillips, David Chandler, Richard J. Hillman, Andrew E. Grulich, Fengyi Jin, I. Mary Poynten, David J. Templeton, Alyssa M. Cornall
Article
Immunology
Eric P. F. Chow, Sepehr N. Tabrizi, Christopher K. Fairley, Rebecca Wigan, Dorothy A. Machalek, David G. Regan, Jane S. Hocking, Suzanne M. Garland, Alyssa M. Cornall, Steph Atchison, Catriona S. Bradshaw, Anna McNulty, Louise Owen, Lewis Marshall, Darren B. Russell, John M. Kaldor, Marcus Y. Chen
Article
Microbiology
Gerald L. Murray, Jennifer Danielewski, Catriona S. Bradshaw, Deborah A. Williamson, Joshua Birnie, Jenny P. Su, Vesna De Petra, Lit Y. Tan, Rachel Wee, Dorothy A. Machalek, Tim R. H. Read, Suzanne M. Garland
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Oncology
Jennifer M. Roberts, Isobel M. Poynten, Monica Molano, Dorothy A. Machalek, Richard J. Hillman, Patricia Guzman, Fengyi Jin, David J. Templeton, Christopher K. Fairley, Carmella Law, Suzanne M. Garland, Andrew E. Grulich, Alyssa M. Cornall
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Microbiology
Gerald L. Murray, Michelle Doyle, Kaveesha Bodiyabadu, Lenka A. Vodstrcil, Suzanne M. Garland, Jennifer Danielewski, Dorothy A. Machalek, Colette McGuinness, Erica L. Plummer, Vesna De Petra, Deborah A. Williamson, Catriona S. Bradshaw
Summary: The ResistancePlus MG FleXible test showed comparable performance to the standard open platform test for detecting M. genitalium and had improved detection of MRMs.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Dorothy Machalek, Helen Rees, Admire Chikandiwa, Richard Munthali, Danielle Travill, Zizipho Mbulawa, Kathy Petoumenos, Sinead Delany-Moretlwe, John Kaldor
Summary: This study aims to evaluate the impact of the national South African HPV vaccination program, including the impact of both two-dose and single-dose vaccine schedules on HPV prevalence, using a hybrid impact evaluation approach.
Article
Multidisciplinary Sciences
Dorothy A. B. Machalek, Kaitlyn M. Vette, Marnie Downes, John B. O. Carlin, Suellen B. Nicholson, Rena F. Hirani, David O. Irving, Iain B. Gosbell, Heather F. Gidding, Hannah M. Shilling, Eithandee Aung, Kristine Macartney, John M. Kaldor
Summary: This study estimated the seroprevalence of SARS-CoV-2 antibodies among blood donors in metropolitan Melbourne during the COVID-19 outbreak. The results suggest low community transmission and good case ascertainment during the second epidemic wave. The study highlights the usefulness of residual blood donor samples in assessing seroprevalence and population patterns of infection.
Article
Oncology
Jennifer Margaret Roberts, Dorothy A. Machalek, Bethan C. Butler, Joanne Crescini, Suzanne M. Garland, Annabelle Farnsworth
Summary: In Australia's HPV-based cervical screening program, the risk of histological high-grade abnormality decreased with age in women with oncogenic HPV. This study followed HPV16/18 positive women aged 55 years and over for up to 3 years to determine the proportion with histological high-grade abnormality and its correlation with liquid-based cytology result and prior screening history. The results showed that age, screening history, and cytology result are important factors to consider in managing screen-detected abnormalities in HPV-based cervical screening programs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Maxence Gandelin, Phuong Lien Tran, Emmanuel Chirpaz, Marie-Christine Jaffar-Bandjee, Nicolas Traversier, Dorothy Machalek, Antoine Bertolotti
Summary: Reunion Island has higher cervical cancer incidence and mortality rates compared to mainland France, with disparities in HPV prevalence. However, vaccination and screening coverage on the island are low. It is crucial to understand HPV infection burden and risk factors in the young Reunionese population to improve vaccination and screening programs.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Microbiology
Kaveesha Bodiyabadu, Jennifer Danielewski, Suzanne M. Garland, Dorothy A. Machalek, Catriona S. Bradshaw, Joshua Birnie, Samantha Ebeyan, Marie Lundgren, Gerald Murray
Summary: The MG+parC(beta2) assay showed high sensitivity and specificity for parC SNP detection, providing insights into treatment failure causes, but is not yet ready for clinical application due to incomplete understanding of fluoroquinolone resistance mechanisms.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Virology
Dorothy A. Machalek, Fengyi Jin, I. Mary Poynten, Richard J. Hillman, David J. Templeton, Carmella Law, Jennifer M. Roberts, Sepehr N. Tabrizi, Suzanne M. Garland, Annabelle Farnsworth, Christopher K. Fairley, Andrew E. Grulich
PAPILLOMAVIRUS RESEARCH
(2016)