Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury

(2015) Anthony W. Ashton et al.   MOLECULAR ENDOCRINOLOGY

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

(2015) Priscila Y. Sato et al.   PHYSIOLOGICAL REVIEWS

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

(2014) Jonathan E. Hullmann et al.   CIRCULATION RESEARCH

Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation

(2013) Alessandro Cannavo et al.   APOPTOSIS

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

(2013) Mai Chen et al.   CIRCULATION RESEARCH

Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo

(2013) Smail Messaoudi et al.   HYPERTENSION

Estrogen Receptor-β in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats

(2013) Baojian Xue et al.   HYPERTENSION

Cross-talk between mineralocorticoid receptor/angiotensin II type 1 receptor and mitogen-activated protein kinase pathways underlies aldosterone-induced atrial fibrotic responses in HL-1 cardiomyocytes

(2013) Chin-Feng Tsai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

(2013) Jessica I. Gold et al.   PLoS One

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

(2013) Qian Fan et al.   PLoS One

Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure

(2013) Giuseppe Rengo et al.   European Journal of Preventive Cardiology

Genetic Deletion of Uncoupling Protein 3 Exaggerates Apoptotic Cell Death in the Ischemic Heart Leading to Heart Failure

(2013) Cinzia Perrino et al.   Journal of the American Heart Association

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy

(2013) Alessandro Cannavo et al.   Frontiers in Physiology

ARB and Cardioprotection

(2012) Hiroshi Akazawa et al.   CARDIOVASCULAR DRUGS AND THERAPY

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

(2012) Jessica I. Gold et al.   CIRCULATION RESEARCH

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

Functional Cross-Talk Between Aldosterone and Angiotensin-(1-7) in Ventricular Myocytes

(2012) Pedro W. Machado de Almeida et al.   HYPERTENSION

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

Aldosterone: effects on the kidney and cardiovascular system

(2010) Marie Briet et al.   Nature Reviews Nephrology

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldosterone-Induced Activation of Signaling Pathways Requires Activity of Angiotensin Type 1a Receptors

(2009) Catherine A. Lemarié et al.   CIRCULATION RESEARCH

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

(2009) Jihee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single plasmids expressing human steroid hormone receptors and a reporter gene for use in yeast signaling assays

(2009) Charles A. Miller et al.   PLASMID

Cardiac Cell HypertrophyIn Vitro

(2008) Matilde Colella et al.   Annals of the New York Academy of Sciences

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

Cross-Talk Between Mineralocorticoid and Angiotensin II Signaling for Cardiac Remodeling

(2008) An Di Zhang et al.   HYPERTENSION

Aldosterone Nongenomically Produces NADPH Oxidase−Dependent Reactive Oxygen Species and Induces Myocyte Apoptosis

(2008) Hironori HAYASHI et al.   HYPERTENSION RESEARCH

Modulation of Adrenal Catecholamine Secretion by In Vivo Gene Transfer and Manipulation of G Protein–coupled Receptor Kinase-2 Activity

(2008) Anastasios Lymperopoulos et al.   MOLECULAR THERAPY

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA