Current Advances in the Biochemical and Physiological Aspects of the Treatment of Type 2 Diabetes Mellitus with Thiazolidinediones

AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation

(2016) Jing Jia et al.   MICROVASCULAR RESEARCH

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists

(2015) Hao Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma

(2015) Pimonrat Ketsawatsomkron et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue

(2015) Yang Liu et al.   DIABETES

Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control

(2015) A.J. Scheen et al.   DIABETES & METABOLISM

CD36Gene Variants in Early Prediction of Type 2 Diabetes Mellitus

(2015) Sunaina Gautam et al.   Genetic Testing and Molecular Biomarkers

Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor α/γ

(2015) Jademilson Celestino dos Santos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Systemic PPARγ deletion causes severe disturbance in fluid homeostasis in mice

(2015) Li Zhou et al.   PHYSIOLOGICAL GENOMICS

Structure–function relationships in nuclear receptors: the facts

(2015) Dino Moras et al.   TRENDS IN BIOCHEMICAL SCIENCES

Review of the Structural and Dynamic Mechanisms of PPARγPartial Agonism

(2015) Alice J. Kroker et al.   PPAR Research

Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention

(2015) Shoko Horita et al.   PPAR Research

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

(2014) Limei Wang et al.   BIOCHEMICAL PHARMACOLOGY

Revisiting PPARγ as a target for the treatment of metabolic disorders

(2014) Sun-Sil Choi et al.   BMB Reports

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients

(2014) Mark A. Babizhayev et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

(2014) Nathalie Esser et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia-induced atherosclerosis

(2014) Perinur Bozaykut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Vegetables′ juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications

(2014) AshokK Tiwari et al.   Pharmacognosy Magazine

Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts

(2014) Huamei He et al.   TOXICOLOGICAL SCIENCES

Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ

(2014) Lianying Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect and cardiovascular safety of adding rosiglitazone to insulin therapy in type 2 diabetes: A meta-analysis

(2014) Yu Lu et al.   Journal of Diabetes Investigation

Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline From the American College of Physicians

(2013) Amir Qaseem et al.   ANNALS OF INTERNAL MEDICINE

Peroxisome Proliferator-Activated Receptor-γ Mutations Responsible for Lipodystrophy With Severe Hypertension Activate the Cellular Renin–Angiotensin System

(2013) Martine Auclair et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus

(2013) Y. Atamer et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Discovery of Thiazolidine-2,4-Dione/Biphenylcarbonitrile Hybrid as Dual PPAR α/γ Modulator with Antidiabetic Effect:In vitro, In SilicoandIn VivoApproaches

(2013) Sergio Hidalgo-Figueroa et al.   Chemical Biology & Drug Design

Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice

(2013) Konstantinos Drosatos et al.   Circulation-Heart Failure

Dual Peroxisome Proliferator-Activated Receptor  /  Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects

(2013) B. Cariou et al.   DIABETES CARE

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II

(2013) Joshua A. Beckman et al.   EUROPEAN HEART JOURNAL

Molecular determinants for nuclear receptors selectivity: Chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists

(2013) Antonio Carrieri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia-Inducible Factor-1α in Vascular Smooth Muscle Regulates Blood Pressure Homeostasis Through a Peroxisome Proliferator–Activated Receptor-γ–Angiotensin II Receptor Type 1 Axis

(2013) Yan Huang et al.   HYPERTENSION

Rosiglitazone Decreases Bone Mineral Density and Increases Bone Turnover in Postmenopausal Women With Type 2 Diabetes Mellitus

(2013) John P. Bilezikian et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

(2013) Francisco A. Monsalve et al.   MEDIATORS OF INFLAMMATION

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Phytol/Phytanic Acid and Insulin Resistance: Potential Role of Phytanic Acid Proven by Docking Simulation and Modulation of Biochemical Alterations

(2013) Mohamed M. Elmazar et al.   PLoS One

PPAR Agonist-Induced Reduction of Mcp1 in Atherosclerotic Plaques of Obese, Insulin-Resistant Mice Depends on Adiponectin-Induced Irak3 Expression

(2013) Maarten Hulsmans et al.   PLoS One

Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors

(2013) Stéphane Mandard et al.   PPAR Research

Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone

(2013) Rodrigo N Lamounier et al.   Diabetology & Metabolic Syndrome

The origin of circulating CD36 in type 2 diabetes

(2013) M J Alkhatatbeh et al.   Nutrition & Diabetes

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Fatty Acids Regulate Endothelial Lipase and Inflammatory Markers in Macrophages and in Mouse Aorta

(2012) Un Ju Jung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin Resistance: Metabolic Mechanisms and Consequences in the Heart

(2012) E. Dale Abel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists

(2012) Bin Xiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents

(2012) Vasudeva Rao Avupati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists

(2012) Hyo Jin Gim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Submaximal PPARγ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disorders

(2012) Pitchai Balakumar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiovascular disease risk reduction by raising HDL cholesterol - current therapies and future opportunities

(2012) K Mahdy Ali et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diabetes and cancer II: role of diabetes medications and influence of shared risk factors

(2012) Adedayo A. Onitilo et al.   CANCER CAUSES & CONTROL

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

Diabetes and Hypertension: Is There a Common Metabolic Pathway?

(2012) Bernard M. Y. Cheung et al.   Current Atherosclerosis Reports

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2012) S. E. Inzucchi et al.   DIABETES CARE

PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty

(2012) Janice V. Huang et al.   JOURNAL OF LIPID RESEARCH

New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression

(2012) A. Laghezza et al.   JOURNAL OF MEDICINAL CHEMISTRY

PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

(2012) C.V. Araújo et al.   MICROVASCULAR RESEARCH

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

(2012) Travis S. Hughes et al.   STRUCTURE

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of Gene Regulation by Fatty Acids

(2012) Anastasia Georgiadi et al.   Advances in Nutrition

Healing the Diabetic Heart: Modulation of Cardiometabolic Syndrome through Peroxisome Proliferator Activated Receptors (PPARs)

(2012) Tom Hsun-Wei Huang et al.   Current Molecular Pharmacology

Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists

(2011) Hyo Jin Gim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interplay between statins and PPARs in improving cardiovascular outcomes: a double-edged sword?

(2011) Pitchai Balakumar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of in-stent restenosis in the APPROACH trial (assessment on the prevention of progression by Rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history)

(2011) Héctor M. García-García et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Adiposopathy

(2011) Harold E. Bays   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system

(2011) Min-Chul Cho et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Induction of peroxisomal proliferator-activated receptor γ and peroxisomal proliferator-activated receptor γ coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue1,2

(2010) P. García-Rojas et al.   JOURNAL OF ANIMAL SCIENCE

Pharmacophore-driven identification of PPARγ agonists from natural sources

(2010) Rasmus K. Petersen et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN